Mechanisms of Hepatic Microcirculatory Disturbances Induced by Acute Ethanol Administration in Rats, With Special Reference to Alterations of Sinusoidal Endothelial Fenestrae

Elucidation of the hepatic hemodynamics in acute ethanol administration is an issue of clinical importance for better understanding of alcoholic liver diseases. The purpose of this study is to clarify the mechanism of hepatic microcirculatory disturbances after acute ethanol administration, especial...

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Bibliographic Details
Published in:	Alcoholism, clinical and experimental research Vol. 23; no. s4; pp. 39S - 46S
Main Authors:	Takashimizu, Shinji, Watanabe, Norihito, Nishizaki, Yasuhiro, Kawazoe, Kazuya, Matsuzaki, Shohei
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-04-1999 Lippincott Williams & Wilkins
Subjects:	Alcoholism and acute alcohol poisoning Animals Antihypertensive Agents - pharmacology Biological and medical sciences Blood Flow Velocity Endo-thelin Receptor Antagonist Endothelin Receptor Antagonists Endothelin-1 - physiology Endothelin-l Endothelium, Vascular - drug effects Endothelium, Vascular - ultrastructure Ethanol Ethanol - administration & dosage Ethanol - adverse effects Ethanol - blood Hepatic Microcirculation Hypertension, Portal - chemically induced Infusions, Intravenous Liver - blood supply Male Medical sciences Mesenteric Veins Microscopy, Electron Microscopy, Electron, Scanning Peptides, Cyclic - pharmacology Portal Vein - drug effects Rats Rats, Wistar Receptor, Endothelin A Sinusoidal Endothelial Fenestrae Toxicology Venous Pressure Endothelin Intravenous administration Ethanol Rat Toxicity Rodentia Single dose Peptide hormone Cardiovascular disease Hepatic disease Endothelin 1 Hepatic sinus Microcirculation Vertebrata Mammalia Animal Digestive diseases Vasoconstrictor agent Mechanism of action
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