Insulin-like growth factor binding protein (IGFBP) inhibits IGF action on human osteosarcoma cells

The influence of a human insulin-like growth factor binding protein, hIGFBP-1, on the action of IGFs on human osteosarcoma cells was examined. hIGFBP-1 was found to block binding of IGFs to their receptors on MG-63 cells and subsequent IGF stimulation of DNA synthesis. Concurrent incubation of hIGFB...

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Bibliographic Details

Published in:	Journal of cellular physiology Vol. 149; no. 2; p. 293
Main Authors:	Campbell, P G, Novak, J F
Format:	Journal Article
Language:	English
Published:	United States 01-11-1991
Subjects:	Carrier Proteins - metabolism Carrier Proteins - pharmacology DNA - biosynthesis Humans Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor I - antagonists & inhibitors Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor II - antagonists & inhibitors Insulin-Like Growth Factor II - metabolism Osteosarcoma - metabolism Receptors, Cell Surface - metabolism Receptors, Somatomedin Tumor Cells, Cultured
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