Influence of Age on the Safety, Tolerability, and Pharmacokinetics of the Novel HMG-CoA Reductase Inhibitor Cerivastatin in Healthy Male Volunteers

The safety, tolerability, and pharmacokinetics of cerivastatin, a novel, synthetic, potent, and highly selective HMG‐CoA reductase inhibitor, were studied in 48 young and elderly male volunteers in a randomized, double‐blind, placebo‐controlled study. Eight men ranging from 18 to 38 years of age (yo...

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Bibliographic Details
Published in:	Journal of clinical pharmacology Vol. 38; no. 8; pp. 715 - 719
Main Authors:	Mazzu, Arthur, Lettieri, John, Kaiser, Lee, Mullican, William, Heller, Allen H.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-08-1998 Sage Science
Subjects:	Adult Aged Aging - metabolism Area Under Curve Biological and medical sciences Double-Blind Method General and cellular metabolism. Vitamins Half-Life Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Male Medical sciences Pharmacology. Drug treatments Pyridines - adverse effects Pyridines - pharmacokinetics Human Enzyme Toxicity Oral administration Enzyme inhibitor Bioavailability Normal Biological activity Cerivastatin Randomization Double blind study Clinical trial Hydroxymethylglutaryl-CoA reductase Oxidoreductases Pharmacokinetics Antilipemic agent
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