Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy

: Idiopathic membranous nephropathy (MN), an autoimmune‐mediated glomerulonephritis, is one of the most common causes of nephrotic syndrome in adults. Therapeutic agents for MN remain ill defined. We assessed the efficacy of melatonin therapy for MN. Experimental murine MN was induced with cationic...

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Bibliographic Details
Published in:	Journal of pineal research Vol. 52; no. 4; pp. 460 - 469
Main Authors:	Wu, Chia-Chao, Lu, Kuo-Cheng, Lin, Gu-Jiun, Hsieh, Hsin-Yi, Chu, Pauling, Lin, Shih-Hua, Sytwu, Huey-Kang
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-05-2012
Subjects:	Analysis of Variance Animals Antigens, CD - biosynthesis Antigens, CD - immunology apoptosis Apoptosis - drug effects Cattle Cytokines - genetics Cytokines - metabolism Female Glomerulonephritis, Membranous - blood Glomerulonephritis, Membranous - drug therapy Glomerulonephritis, Membranous - enzymology Glomerulonephritis, Membranous - immunology heme oxygenase-1 Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Histocytochemistry immunomodulation Kidney - chemistry Kidney - drug effects Kidney - pathology Lymphocytes - drug effects Lymphocytes - immunology melatonin Melatonin - pharmacology membranous nephropathy Mice Mice, Inbred BALB C Protective Agents - pharmacology Serum Albumin, Bovine
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