Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting Mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma

Mesothelin, a differentiation antigen, is a 40-kD glycosylphosphatidylinositol-linked cell-surface glycoprotein, that is present on the surface of normal mesothelium and is overexpressed in many patients with epithelial ovarian cancer and malignant mesotheliomas. Monoclonal antibody K1 is a murine i...

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Bibliographic Details
Published in:	Journal of immunotherapy (1997) Vol. 23; no. 4; pp. 473 - 479
Main Authors:	HASSAN, R, VINER, J. L, WANG, Q.-C, MARGULIES, I, KREITMAN, R. J, PASTAN, I
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott 01-07-2000 Philadelphia,PA
Subjects:	ADP Ribose Transferases Animals Antibodies, Monoclonal - therapeutic use Antigens, Neoplasm - immunology Antigens, Neoplasm - isolation & purification Antigens, Neoplasm - therapeutic use Antineoplastic agents Bacterial Toxins Biological and medical sciences Exotoxins - genetics Exotoxins - immunology Exotoxins - isolation & purification Exotoxins - therapeutic use Female GPI-Linked Proteins Humans Immunotherapy Immunotoxins - immunology Immunotoxins - isolation & purification Immunotoxins - therapeutic use Medical sciences Membrane Glycoproteins - immunology Membrane Glycoproteins - isolation & purification Membrane Glycoproteins - therapeutic use Mesothelin Mesothelioma - immunology Mesothelioma - therapy Mice Mice, Nude Mutation Ovarian Neoplasms - immunology Ovarian Neoplasms - therapy Pharmacology. Drug treatments Pseudomonas aeruginosa Exotoxin A Tumor Cells, Cultured Virulence Factors Pseudomonadales Antineoplastic agent Animal model Immunotoxin Gene overexpression Cytotoxicity Monoclonal antibody Pseudomonas Cell surface Ovary Immunotherapy Established cell line Bacteria Pseudomonadaceae Human Squamous cell carcinoma Treatment efficiency Rodentia Malignant tumor Gene expression In vitro Biological activity Antigen In vivo Vertebrata Malignant mesothelioma Mammalia Mouse Animal Conjugated compound
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