Role of Ischemic Preconditioning in Liver Surgery and Hepatic Transplantation

• Published in: Journal of gastrointestinal surgery Vol. 13; no. 11; pp. 2074 - 2083
• Main Authors: Montalvo-Jave, Eduardo E., Piña, Enrique, Montalvo-Arenas, Cesar, Urrutia, Raúl, Benavente-Chenhalls, Luis, Peña-Sanchez, Julieta, Geller, David A.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01-11-2009; Springer Nature B.V
• Subjects: Animals; Fatty Liver - physiopathology; Gastroenterology; Hepatectomy; Hepatocytes - physiology; Humans; Ischemic Preconditioning - methods; Liver; Liver - physiopathology; Liver Circulation; Liver Transplantation - physiology; Medicine; Medicine & Public Health; Nitric Oxide - metabolism; Preoperative Care; Regional Blood Flow; Reperfusion Injury - physiopathology; Reperfusion Injury - prevention & control; Review Article; Surgery; Transplants & implants; Ischemia–reperfusion injury; Ischemic preconditioning; Hepatic transplantation; Preconditioning; Liver; Surgery
• ISSN: 1091-255X; 1873-4626
• DOI: 10.1007/s11605-009-0878-7

Introduction
The purpose of this review is to summarize intraoperative surgical strategies available to decrease ischemia–reperfusion injury associated with liver resection and liver transplantation.
Material and method
We conducted a critical review of the literature evaluating the potential applications of hepatic ischemic preconditioning (IPC) for hepatic resection surgery and liver transplantation. In addition, we provide a basic bench-to-bedside summary of the liver physiology and cell signaling mechanisms that account for the protective effects seen with hepatic IPC.