Evaluating the Safety and Quality of Life of Colorectal Cancer Patients Treated by Autologous Immune Enhancement Therapy (AIET) in Vinmec International Hospitals

• Published in: International journal of molecular sciences Vol. 23; no. 19; p. 11362
• Main Authors: Nguyen, Hoang-Phuong, Pham, Duc-Anh Dao, Dinh Nguyen, Duy, Nguyen, Phong Van, Bui, Viet-Anh, Hoang, My-Nhung Thi, Nguyen, Liem Thanh
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26-09-2022; MDPI
• Subjects: autologous immune enhancement therapy; Bone marrow; Cell culture; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms; Cytokines; cytotoxic T lymphocytes; Cytotoxicity; Hospitals; Humans; Immune system; Killer Cells, Natural; Lymphatic system; Lymphocytes; Lymphocytes T; Metastasis; Natural killer cells; Patients; Quality of Life; Safety; Signs and symptoms; Surveys and Questionnaires; Survival; T-Lymphocytes, Cytotoxic; Japan; natural killer cells; colorectal cancer; cytotoxic T lymphocytes; autologous immune enhancement therapy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms231911362

(1) Colorectal cancer (CRC) is an increasingly prevalent disease with a high mortality rate in recent years. Immune cell-based therapies have received massive attention among scientists, as they have been proven effective as low-toxicity treatments. This study evaluated the safety and effectiveness of autologous immune enhancement therapy (AIET) for CRC. (2) An open-label, single-group study, including twelve patients diagnosed with stages III and IV CRC, was conducted from January 2016 to December 2021. Twelve CRC patients received one to seven infusions of natural killer (NK)-cell and cytotoxic T-lymphocyte (CTL). Multivariate modelling was used to identify factors associated with health-related quality-of-life (HRQoL) scores. (3) After 20−21 days of culture, the NK cells increased 3535-fold, accounting for 85% of the cultured cell population. Likewise, CTLs accounted for 62.4% of the cultured cell population, which was a 1220-fold increase. Furthermore, the QoL improved with increased EORTC QLQ-C30 scores, decreased symptom severity, and reduced impairment in daily living caused by these symptoms (MDASI-GI report). Finally, a 14.3 ± 14.1-month increase in mean survival time was observed at study completion. (4) AIET demonstrated safety and improved survival time and HRQoL for CRC patients in Vietnam.