Comparison of Cryopreserved Homografts and Decellularized Porcine Heterografts Implanted in Sheep
: This study evaluated cryopreserved homografts (Group 1) and porcine heterografts decellularized with deoxicholic acid (Group 2), implanted in the right ventricular outflow tract of juvenile sheep. Two groups with four animals in each were used and all animals survived with good outcome. Animals w...
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| Published in: | Artificial organs Vol. 28; no. 4; pp. 366 - 370 |
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| Format: | Journal Article |
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Oxford, UK and Malden, USA
Blackwell Science Inc
01-04-2004
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| Abstract | : This study evaluated cryopreserved homografts (Group 1) and porcine heterografts decellularized with deoxicholic acid (Group 2), implanted in the right ventricular outflow tract of juvenile sheep. Two groups with four animals in each were used and all animals survived with good outcome. Animals were sacrificed 90 or more days after surgery (90–150 days). On the third and fifth postoperative months they were submitted to echocardiographic examination with normal function and appearance observed for both groups. Explants were evaluated through histological analysis, atomic spectrophotometry and radiological examination. Calcium content was higher in the cusps of cryopreserved homografts, despite an otherwise similar macroscopic appearance between grafts of both groups. Decellularized heterografts were progressively repopulated by autologous cells suggesting some regenerative ability and longer durability than conventional homografts. |
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| AbstractList | This study evaluated cryopreserved homografts (Group 1) and porcine heterografts decellularized with deoxicholic acid (Group 2), implanted in the right ventricular outflow tract of juvenile sheep. Two groups with four animals in each were used and all animals survived with good outcome. Animals were sacrificed 90 or more days after surgery (90-150 days). On the third and fifth postoperative months they were submitted to echocardiographic examination with normal function and appearance observed for both groups. Explants were evaluated through histological analysis, atomic spectrophotometry and radiological examination. Calcium content was higher in the cusps of cryopreserved homografts, despite an otherwise similar macroscopic appearance between grafts of both groups. Decellularized heterografts were progressively repopulated by autologous cells suggesting some regenerative ability and longer durability than conventional homografts. : This study evaluated cryopreserved homografts (Group 1) and porcine heterografts decellularized with deoxicholic acid (Group 2), implanted in the right ventricular outflow tract of juvenile sheep. Two groups with four animals in each were used and all animals survived with good outcome. Animals were sacrificed 90 or more days after surgery (90–150 days). On the third and fifth postoperative months they were submitted to echocardiographic examination with normal function and appearance observed for both groups. Explants were evaluated through histological analysis, atomic spectrophotometry and radiological examination. Calcium content was higher in the cusps of cryopreserved homografts, despite an otherwise similar macroscopic appearance between grafts of both groups. Decellularized heterografts were progressively repopulated by autologous cells suggesting some regenerative ability and longer durability than conventional homografts. |
| Author | Brenner Affonso da Costa, Marise Costa, Francisco Diniz Affonso da Vieira, Eduardo Discher Costa, Iseu Affonso da Konertz, Wolfgang Lopes, Sergio Veiga Pohl, Felipe Lacerda, Guilherme Vilani, Ricardo Dohmen, Pascal Maria Yoschi, S. |
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| Cites_doi | 10.1016/S0003-4975(02)04351-5 10.1177/021849230201000107 10.1016/S0003-4975(01)02503-6 10.1590/S0066-782X2002001400016 10.1016/S0003-4975(02)03881-X 10.1016/S0022-5223(19)35182-7 10.1016/S0002-9149(02)03323-4 10.1177/039139880202501108 10.1067/mtc.2002.124514 10.1016/S0003-4975(01)02502-4 |
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| References_xml | – volume: 71 start-page: 422 year: 2001 end-page: 7 article-title: Stentless bioprosthetic heart valve research: sheep versus primate model publication-title: Ann Thorac Surg – volume: 10 start-page: 334 year: 2001 end-page: 45 article-title: The homograft aortic valve: a 29‐year follow‐up of 1022 valve replacements publication-title: J Heart Valve Dis – volume: 13 start-page: 87 issue: S1 year: 2001 end-page: 92 article-title: Recelularization of heart valve grafts by a process of adaptive remodeling publication-title: Thorac Cardiovasc Surg – volume: 74 start-page: 1438 year: 2002 end-page: 42 article-title: Ross operation with a tissue‐engineered heart valve publication-title: Ann Thorac Surg – volume: 96 start-page: 746 year: 1993 end-page: 55 article-title: Cryopreserved and fresh antibiotic sterilized valved aortic homografts conduits in a long‐term sheep model. Hemodynamic angiographic and histologic comparisons publication-title: J Thorac Cardiovasc Surg – volume: 25 start-page: 1089 year: 2002 end-page: 94 article-title: In vitro hydrodynamics of a decelularized pulmonary porcine valve, compared with glutaraldehyde and polyurethane heart valve publication-title: Int J Artif Organs – volume: 124 start-page: 689 year: 2002 end-page: 97 article-title: The pathology of fresh and cryopreserved homograft heart valves: an analysis of forty explanted homograft valves publication-title: J Thorac Cardiovasc Surg – volume: 13 start-page: 98 year: 2001 article-title: Lack of calcification of tissue engineered heart valves in juvenile sheep publication-title: Semin Thorac Cardiovasc Surg – volume: 13 start-page: 82 issue: S1 year: 2001 end-page: 6 article-title: Humoral immune response to allograft valve tissue pretreated with an antigen reduction process publication-title: Thorac Cardiovasc Surg – volume: 13 start-page: 93 issue: S1 year: 2001 end-page: 8 article-title: Lack of calcification of tissue engineered heart valves in juvenile sheep publication-title: Thorac Cardiovasc Surg – volume: 79 start-page: 1 year: 2002 end-page: 5 article-title: Valvas Cardíacas Obtidas por Engenharia de Tecidos. A Mais Nova Geração de Próteses Biológicas publication-title: Arq Bras Cardiol – volume: 71 start-page: 428 year: 2001 end-page: 32 article-title: Decelularized human valve allografts publication-title: Ann Thorac Surg – start-page: 287 year: 1981; end-page: 306 – volume: 11 start-page: 194 issue: S1 year: 1999 end-page: 200 article-title: The synergraft valve: a new acellular (nonglutaraldehyde‐fixed) tissue heart valve for autologous recelularization: first experimental studies before clinical implantation publication-title: Thorac Cardiovasc Surg – volume: 10 start-page: 25 year: 2002 end-page: 30 article-title: Tissue engineering of an auto‐xenograft pulmonary heart valve publication-title: Asian Cardiovasc Thorac Ann – volume: 74 start-page: 1434 year: 2002 article-title: Tissue‐engineered valves publication-title: Ann Thorac Surg – volume: 13 start-page: 99 issue: Suppl. 1 year: 2001 end-page: 105 article-title: Influence of species, environmental factors and tissue cellularity on calcification of porcine aortic wall tissue publication-title: Thorac Cardiovasc Surg – volume: 11 start-page: 171 issue: S1 year: 1999 end-page: 5 article-title: The no‐react anticalcification treatment: a comparison of Biocor no‐react II and Toronto SPV stentless bioprostheses implanted in sheep publication-title: Thorac Cardiovasc Surg – volume: 13 start-page: 1 issue: Suppl. 1 year: 2001 end-page: 6 article-title: Influence of design and fixation pressure on fibrous sheathing in right‐sided porcine aortic bioprostheses publication-title: Thorac Cardiovasc Surg – volume: 13 start-page: 99 issue: 1 year: 2001 ident: e_1_2_6_18_2 article-title: Influence of species, environmental factors and tissue cellularity on calcification of porcine aortic wall tissue publication-title: Thorac Cardiovasc Surg contributor: fullname: Meuris B – volume: 13 start-page: 93 issue: 1 year: 2001 ident: e_1_2_6_12_2 article-title: Lack of calcification of tissue engineered heart valves in juvenile sheep publication-title: Thorac Cardiovasc Surg contributor: fullname: Dohmen PM – start-page: 287 volume-title: Replacement Cardiac Valves. year: 1981 ident: e_1_2_6_2_2 contributor: fullname: Bodnar E – volume: 13 start-page: 87 issue: 1 year: 2001 ident: e_1_2_6_13_2 article-title: Recelularization of heart valve grafts by a process of adaptive remodeling publication-title: Thorac Cardiovasc Surg contributor: fullname: Elkins RC – volume: 13 start-page: 98 year: 2001 ident: e_1_2_6_5_2 article-title: Lack of calcification of tissue engineered heart valves in juvenile sheep publication-title: Semin Thorac Cardiovasc Surg contributor: fullname: Dohmen PM – ident: e_1_2_6_9_2 doi: 10.1016/S0003-4975(02)04351-5 – ident: e_1_2_6_14_2 doi: 10.1177/021849230201000107 – ident: e_1_2_6_7_2 doi: 10.1016/S0003-4975(01)02503-6 – ident: e_1_2_6_6_2 doi: 10.1590/S0066-782X2002001400016 – volume: 11 start-page: 171 issue: 1 year: 1999 ident: e_1_2_6_15_2 article-title: The no‐react anticalcification treatment: a comparison of Biocor no‐react II and Toronto SPV stentless bioprostheses implanted in sheep publication-title: Thorac Cardiovasc Surg contributor: fullname: Herijgers P – ident: e_1_2_6_8_2 doi: 10.1016/S0003-4975(02)03881-X – volume: 96 start-page: 746 year: 1993 ident: e_1_2_6_19_2 article-title: Cryopreserved and fresh antibiotic sterilized valved aortic homografts conduits in a long‐term sheep model. Hemodynamic angiographic and histologic comparisons publication-title: J Thorac Cardiovasc Surg doi: 10.1016/S0022-5223(19)35182-7 contributor: fullname: Jonas RA – ident: e_1_2_6_3_2 doi: 10.1016/S0002-9149(02)03323-4 – volume: 11 start-page: 194 issue: 1 year: 1999 ident: e_1_2_6_10_2 article-title: The synergraft valve: a new acellular (nonglutaraldehyde‐fixed) tissue heart valve for autologous recelularization: first experimental studies before clinical implantation publication-title: Thorac Cardiovasc Surg contributor: fullname: O'Brien MF – ident: e_1_2_6_11_2 doi: 10.1177/039139880202501108 – ident: e_1_2_6_20_2 doi: 10.1067/mtc.2002.124514 – volume: 13 start-page: 1 issue: 1 year: 2001 ident: e_1_2_6_17_2 article-title: Influence of design and fixation pressure on fibrous sheathing in right‐sided porcine aortic bioprostheses publication-title: Thorac Cardiovasc Surg contributor: fullname: Ozaki S – ident: e_1_2_6_16_2 doi: 10.1016/S0003-4975(01)02502-4 – volume: 13 start-page: 82 issue: 1 year: 2001 ident: e_1_2_6_4_2 article-title: Humoral immune response to allograft valve tissue pretreated with an antigen reduction process publication-title: Thorac Cardiovasc Surg contributor: fullname: Elkins RC |
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| Snippet | : This study evaluated cryopreserved homografts (Group 1) and porcine heterografts decellularized with deoxicholic acid (Group 2), implanted in the right... This study evaluated cryopreserved homografts (Group 1) and porcine heterografts decellularized with deoxicholic acid (Group 2), implanted in the right... |
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| SubjectTerms | Acellular Animals Aortic Bioprosthesis Calcification Calcinosis - diagnostic imaging Calcium - analysis Cryopreservation Extracellular Matrix - physiology Fibroblasts - metabolism Heart Valve Prosthesis Heart valves Pulmonary Pulmonary Valve - surgery Radiography Sheep Swine Tissue Engineering - methods |
| Title | Comparison of Cryopreserved Homografts and Decellularized Porcine Heterografts Implanted in Sheep |
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