CROHN'S DISEASE AND SECONDARY AMYLOIDOSIS: EARLY COMPLICATION? A CASE REPORT AND REVIEW OF THE LITERATURE

• Published in: Journal of renal care Vol. 35; no. 3; pp. 147 - 150
• Main Authors: Basturk, Taner, Ozagarı, Aysım, Ozturk, Tulım, Kusaslan, Ramazan, Unsal, Abdulkadır
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-09-2009
• Subjects: Adult; Amyloidosis - blood; Amyloidosis - diagnosis; Amyloidosis - etiology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Biopsy; Colchicine - therapeutic use; Crohn Disease - complications; Crohn Disease - diagnosis; Crohn Disease - drug therapy; Crohn's disease; Disease Progression; Early Diagnosis; Humans; Hypertension - etiology; Hypoalbuminemia - etiology; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - therapy; Male; Mesalamine - therapeutic use; Nursing; Proteinuria - etiology; Rare Diseases; Renal Dialysis; Renal failure; Risk Factors; Secondary amyloidosis; Time Factors
• ISSN: 1755-6678; 1755-6686
• DOI: 10.1111/j.1755-6686.2009.00106.x

SUMMARY
Secondary amyloidosis is a rare but serious complication of inflammatory bowel disease (IBD), generally seen in Crohn's disease. At least 1% of patients with Crohn's disease develop amyloidosis. In the literature, the time lapse between the onset of Crohn's disease and the diagnosis of amyloidosis has been reported to range from one to 21 years. In most patients, protein‐uria heralded the onset of renal involvement from amyloid and occurred from three to 15 years after Crohn's disease diagnosis. In this case, we estimate secondary amyloidosis occurred before Crohn's disease or early Crohn's disease complication, based on the fact that hypoalbuminaemia and proteinuria was detected approximately one year after the start of gastrointestinal complaints.