Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum

• Published in: Maternal health, neonatology and perinatology Vol. 5; no. 1; p. 9
• Main Authors: Sánchez-Salguero, Erick, Mondragón-Ramírez, Geovanni Kaleb, Alcántara-Montiel, Julio C, Cérbulo-Vázquez, Arturo, Villegas-Domínguez, Xóchitl, Contreras-Vargas, Víctor Manuel, Thompson-Bonilla, María Del Rocío, Romero-Ramírez, Héctor, Santos-Argumedo, Leopoldo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11-06-2019; BioMed Central; BMC
• Subjects: Antigens; Cesarean section; Chemokines; Colostrum; Communicable diseases; Gastrointestinal system; Gastrointestinal tract; Health aspects; IgA1; IgA2; Immune response; Immune system; Immunoglobulin A; Immunoglobulins; Infections; Infectious diseases; Influenza; Maternal & child health; Medical research; Microbiota; Microorganisms; Milk; Newborn infants; Pregnancy; Pregnant women; Proteins; Respiratory tract; Skin; Vaccines; Mexico; Respiratory tract; Gastrointestinal tract; Colostrum; IgA1; Immunoglobulin A; IgA2; Maternal transfer
• ISSN: 2054-958X; 2054-958X
• DOI: 10.1186/s40748-019-0104-x

Colostrum is the primary source of maternal immunoglobulin A (IgA) for the newborn. IgA participates in protection and regulation mechanisms of the immune response at the neonate's mucosa. Several studies have evaluated infectious diseases and vaccine protocols effects during pregnancy on maternal milk IgA levels, with the aim to understand lactation protecting effect on newborn. However, most of their results demonstrated that there were no differences in the total IgA levels. In humans, IgA has two subclasses (IgA1 and IgA2), they have an anatomical distribution among mucosal compartments, their levels vary after antigen stimulation and are also seen to describe differential affinities in colostrum. Although there are differences between IgA subclasses in several compartments, these studies have excluded specific colostrum IgA1 and IgA2 determination.
We analyzed data from 900 women in Mexico City. With Pearson correlation, we compared the number of infectious episodes during their pregnancy that was associated with mucosal compartments (skin, respiratory and gastrointestinal tracts) and colostrum IgA subclasses.
We show a correlation between increased colostrum IgA1 levels and the number of infectious episodes at respiratory tract and the skin. In contrast, infections at the gastrointestinal tract correlated with increased IgA2 amounts.
nfections present during pregnancy at certain mucosal site increase specific IgA subclasses levels in human colostrum. These results will help in understanding infections and immunizations effects on maternal IgA at the mammary gland, and their impact on the development and protection of the newborn.