Anti-Infection of Oral Microorganisms from Herbal Medicine of Piper crocatum Ruiz & Pav

• Published in: Drug design, development and therapy Vol. 18; pp. 2531 - 2553
• Main Authors: Kurnia, Dikdik, Lestari, Seftiana, Mayanti, Tri, Gartika, Meirina, Nurdin, Denny
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 30-06-2024; Dove; Dove Medical Press
• Subjects: Amino acids; anti-infection; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; antibacterial; antifungal; Drugs; Health aspects; Humans; Infection; Medicine, Botanic; Medicine, Herbal; Methicillin; Microorganisms; Mouth - microbiology; Mouth Diseases - drug therapy; Mouth Diseases - microbiology; oral pathogen; Piper - chemistry; piper crocatum; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Posaconazole; Review; Indonesia; antifungal; antibacterial; anti-infection; oral pathogen; Piper crocatum
• ISSN: 1177-8881; 1177-8881
• DOI: 10.2147/DDDT.S453375

The WHO Global Status Report on Oral Health 2022 reveals that oral diseases caused by infection with oral pathogenic microorganisms affect nearly 3.5 billion people worldwide. Oral health problems are caused by the presence of
and
in the oral cavity. Synthetic anti-infective drugs have been widely used to treat oral infections, but have been reported to cause side effects and resistance. Various strategies have been implemented to overcome this problem. Synthetic anti-infective drugs have been widely used to treat oral infections, but they have been reported to cause side effects and resistance. Therefore, it is important to look for safe anti-infective alternatives. Ethnobotanical and ethnopharmacological studies suggest that Red Betel leaf (
Ruiz & Pav) could be a potential source of oral anti-infectives. This review aims to discuss the pathogenesis mechanism of several microorganisms that play an important role in causing health problems, the mechanism of action of synthetic oral anti-infective drugs in inhibiting microbial growth in the oral cavity, and the potential of red betel leaf (
Ruiz & Pav) as an herbal oral anti-infective drug. This study emphasises the importance of researching natural components as an alternative treatment for oral infections that is more effective and can meet global needs.