Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride

Intramolecular Acylation of Aryl- and Aroyl-Aliphatic Acids by the Action of Pyrophosphoryl Chloride and Phosphorus Oxychloride

Both pyrophosphoryl chloride and phosphorus oxychloride react with aryl aliphatic acids to form mixed anhydrides which undergo intramolecular acylation to afford cyclic ketones without the addition of a Friedel-Crafts catalyst. Aryl and aroylbenzoic acids could be cyclized to the corresponding anthr...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 6; no. 3; pp. 279 - 286
Main Authors: El-Sayrafi, Sami, Rayyan, Saleh
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-03-2001
MDPI
Subjects:
Aluminum
Anthraquinones
Chloride
Cyclic ketones
Cyclodehydration
Fluorides
Hydrocarbons
Investigations
Phosphorus
Phosphorus oxychloride
Pyrophosphoryl chloride
Sulfuric acid
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Summary:Both pyrophosphoryl chloride and phosphorus oxychloride react with aryl aliphatic acids to form mixed anhydrides which undergo intramolecular acylation to afford cyclic ketones without the addition of a Friedel-Crafts catalyst. Aryl and aroylbenzoic acids could be cyclized to the corresponding anthrones and anthraquinones respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/60300279