A simulation tool for mechanical circulatory support device interaction with diseased states

We have created a simulation model to investigate the interactions between a variety of mechanical circulatory support (MCS) devices and the circulatory system with various simulated patient conditions and disease states. The present simulation accommodates a family of continuous-flow MCS devices un...

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Bibliographic Details
Published in:	Journal of artificial organs Vol. 23; no. 2; pp. 124 - 132
Main Authors:	Horvath, David J., Horvath, Dennis W., Karimov, Jamshid H., Kuban, Barry D., Miyamoto, Takuma, Fukamachi, Kiyotaka
Format:	Journal Article
Language:	English
Published:	Tokyo Springer Japan 01-06-2020 Springer Nature B.V
Subjects:	Biomedical Engineering and Bioengineering Cardiac Surgery Circulatory system Computer simulation Continuous flow Medicine Medicine & Public Health Nephrology Original Article Simulation Cardiovascular disease Mock circulation loop Computer simulation Lumped parameter Pumps Heart assist
Online Access:	Get full text
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Summary:	We have created a simulation model to investigate the interactions between a variety of mechanical circulatory support (MCS) devices and the circulatory system with various simulated patient conditions and disease states. The present simulation accommodates a family of continuous-flow MCS devices under various stages of consideration or development at our institution. This article describes the mathematical core of the in silico simulation system and shows examples of simulation output imitating various disease states and of selected in vitro and clinical data from the literature.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1434-7229 1619-0904
DOI:	10.1007/s10047-020-01155-2