Prospective Epidemiological Research Studies in Iran (the PERSIAN Cohort Study): Rationale, Objectives, and Design

Abstract Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors associated with NCDs are preventable; however, it is first necessary to conduct observational studies to identify relevant risk factors and the...

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Published in:	American journal of epidemiology Vol. 187; no. 4; pp. 647 - 655
Main Authors:	Poustchi, Hossein, Eghtesad, Sareh, Kamangar, Farin, Etemadi, Arash, Keshtkar, Abbas-Ali, Hekmatdoost, Azita, Mohammadi, Zahra, Mahmoudi, Zahra, Shayanrad, Amaneh, Roozafzai, Farzin, Sheikh, Mahdi, Jalaeikhoo, Alireza, Somi, Mohammad Hossein, Mansour-Ghanaei, Fariborz, Najafi, Farid, Bahramali, Ehsan, Mehrparvar, Amirhoushang, Ansari-Moghaddam, Alireza, Enayati, Ahmad Ali, Esmaeili Nadimi, Ali, Rezaianzadeh, Abbas, Saki, Nader, Alipour, Fatemeh, Kelishadi, Roya, Rahimi-Movaghar, Afarin, Aminisani, Nayyereh, Boffetta, Paolo, Malekzadeh, Reza
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01-04-2018 Oxford Publishing Limited (England)
Subjects:	Cohort analysis Epidemiology Health risk assessment Medical research Minority & ethnic groups Population studies Quality assurance Risk analysis Risk factors Studies Study Design Urine Iran Prospective Epidemiological Research Studies in Iran (PERSIAN) cohort studies noncommunicable diseases Iran
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Abstract	Abstract Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors associated with NCDs are preventable; however, it is first necessary to conduct observational studies to identify relevant risk factors and the most appropriate approach to controlling them. Iran is a multiethnic country; therefore, in 2014 the Ministry of Health and Medical Education launched a nationwide cohort study—Prospective Epidemiological Research Studies in Iran (PERSIAN)—in order to identify the most prevalent NCDs among Iran’s ethnic groups and to investigate effective methods of prevention. The PERSIAN study consists of 4 population-based cohorts; the adult component (the PERSIAN Cohort Study), described in this article, is a prospective cohort study including 180,000 persons aged 35–70 years from 18 distinct areas of Iran. Upon joining the cohort, participants respond to interviewer-administered questionnaires. Blood, urine, hair, and nail samples are collected and stored. To ensure consistency, centrally purchased equipment is sent to all sites, and the same team trains all personnel. Routine visits and quality assurance/control measures are taken to ensure protocol adherence. Participants are followed for 15 years postenrollment. The PERSIAN study is currently in the enrollment phase; cohort profiles will soon emerge.
AbstractList	Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors associated with NCDs are preventable; however, it is first necessary to conduct observational studies to identify relevant risk factors and the most appropriate approach to controlling them. Iran is a multiethnic country; therefore, in 2014 the Ministry of Health and Medical Education launched a nationwide cohort study—Prospective Epidemiological Research Studies in Iran (PERSIAN)—in order to identify the most prevalent NCDs among Iran’s ethnic groups and to investigate effective methods of prevention. The PERSIAN study consists of 4 population-based cohorts; the adult component (the PERSIAN Cohort Study), described in this article, is a prospective cohort study including 180,000 persons aged 35–70 years from 18 distinct areas of Iran. Upon joining the cohort, participants respond to interviewer-administered questionnaires. Blood, urine, hair, and nail samples are collected and stored. To ensure consistency, centrally purchased equipment is sent to all sites, and the same team trains all personnel. Routine visits and quality assurance/control measures are taken to ensure protocol adherence. Participants are followed for 15 years postenrollment. The PERSIAN study is currently in the enrollment phase; cohort profiles will soon emerge. Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors associated with NCDs are preventable; however, it is first necessary to conduct observational studies to identify relevant risk factors and the most appropriate approach to controlling them. Iran is a multiethnic country; therefore, in 2014 the Ministry of Health and Medical Education launched a nationwide cohort study—Prospective Epidemiological Research Studies in Iran (PERSIAN)—in order to identify the most prevalent NCDs among Iran’s ethnic groups and to investigate effective methods of prevention. The PERSIAN study consists of 4 population-based cohorts; the adult component (the PERSIAN Cohort Study), described in this article, is a prospective cohort study including 180,000 persons aged 35–70 years from 18 distinct areas of Iran. Upon joining the cohort, participants respond to interviewer-administered questionnaires. Blood, urine, hair, and nail samples are collected and stored. To ensure consistency, centrally purchased equipment is sent to all sites, and the same team trains all personnel. Routine visits and quality assurance/control measures are taken to ensure protocol adherence. Participants are followed for 15 years postenrollment. The PERSIAN study is currently in the enrollment phase; cohort profiles will soon emerge. Abstract Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors associated with NCDs are preventable; however, it is first necessary to conduct observational studies to identify relevant risk factors and the most appropriate approach to controlling them. Iran is a multiethnic country; therefore, in 2014 the Ministry of Health and Medical Education launched a nationwide cohort study—Prospective Epidemiological Research Studies in Iran (PERSIAN)—in order to identify the most prevalent NCDs among Iran’s ethnic groups and to investigate effective methods of prevention. The PERSIAN study consists of 4 population-based cohorts; the adult component (the PERSIAN Cohort Study), described in this article, is a prospective cohort study including 180,000 persons aged 35–70 years from 18 distinct areas of Iran. Upon joining the cohort, participants respond to interviewer-administered questionnaires. Blood, urine, hair, and nail samples are collected and stored. To ensure consistency, centrally purchased equipment is sent to all sites, and the same team trains all personnel. Routine visits and quality assurance/control measures are taken to ensure protocol adherence. Participants are followed for 15 years postenrollment. The PERSIAN study is currently in the enrollment phase; cohort profiles will soon emerge.
Author	Rezaianzadeh, Abbas Jalaeikhoo, Alireza Esmaeili Nadimi, Ali Shayanrad, Amaneh Mehrparvar, Amirhoushang Saki, Nader Mohammadi, Zahra Kamangar, Farin Keshtkar, Abbas-Ali Eghtesad, Sareh Poustchi, Hossein Roozafzai, Farzin Bahramali, Ehsan Rahimi-Movaghar, Afarin Mahmoudi, Zahra Etemadi, Arash Aminisani, Nayyereh Sheikh, Mahdi Najafi, Farid Hekmatdoost, Azita Ansari-Moghaddam, Alireza Alipour, Fatemeh Boffetta, Paolo Mansour-Ghanaei, Fariborz Enayati, Ahmad Ali Somi, Mohammad Hossein Kelishadi, Roya Malekzadeh, Reza
AuthorAffiliation	20 Department of Statistics and Epidemiology, Faculty of Health Sciences, Tabriz UMS, Tabriz, Iran 21 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 1 Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences 18 Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan UMS, Isfahan, Iran 8 Department of Gastroenterology, Gastrointestinal and Liver Diseases Research Center, Guilan UMS, Rasht, Iran 3 Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran UMS, Tehran, Iran 7 Liver and Gastrointestinal Diseases Research Center, Tabriz UMS, Tabriz, Iran 10 Noncommunicable Diseases Research Center, Fasa UMS, Fasa, Iran 9 Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah UMS, Kermanshah, Iran 17 Eye Research Center, F
AuthorAffiliation_xml	– name: 13 School of Public Health and Health Sciences Research Center, Mazandaran UMS, Sari, Iran – name: 19 Iranian National Center for Addiction Studies, Tehran UMS, Tehran, Iran – name: 18 Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan UMS, Isfahan, Iran – name: 14 Department of Cardiology, School of Medicine, Rafsanjan UMS, Rafsanjan, Iran – name: 9 Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah UMS, Kermanshah, Iran – name: 21 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York – name: 16 Department of Otolaryngology, Head and Neck Surgery, Hearing and Speech Research Center, Ahvaz Jundishapur UMS, Ahvaz, Iran – name: 12 Health Promotion Research Center, Zahedan UMS, Zahedan, Iran – name: 20 Department of Statistics and Epidemiology, Faculty of Health Sciences, Tabriz UMS, Tabriz, Iran – name: 5 Department of Health Sciences Education Development, School of Public Health, Tehran UMS, Tehran, Iran – name: 8 Department of Gastroenterology, Gastrointestinal and Liver Diseases Research Center, Guilan UMS, Rasht, Iran – name: 10 Noncommunicable Diseases Research Center, Fasa UMS, Fasa, Iran – name: 15 Department of Epidemiology, School of Health, Shiraz UMS, Shiraz, Iran – name: 1 Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – name: 3 Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran UMS, Tehran, Iran – name: 11 Department of Occupational Medicine, Faculty of Medicine, Shahid Sadoughi UMS, Yazd, Iran – name: 17 Eye Research Center, Farabi Eye Hospital, Tehran UMS, Tehran, Iran – name: 4 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland – name: 7 Liver and Gastrointestinal Diseases Research Center, Tabriz UMS, Tabriz, Iran – name: 6 Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Shahid Beheshti UMS, Tehran, Iran – name: 2 Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, Maryland
Author_xml	– sequence: 1 givenname: Hossein surname: Poustchi fullname: Poustchi, Hossein organization: Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – sequence: 2 givenname: Sareh surname: Eghtesad fullname: Eghtesad, Sareh organization: Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – sequence: 3 givenname: Farin surname: Kamangar fullname: Kamangar, Farin organization: Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, Maryland – sequence: 4 givenname: Arash surname: Etemadi fullname: Etemadi, Arash organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland – sequence: 5 givenname: Abbas-Ali surname: Keshtkar fullname: Keshtkar, Abbas-Ali organization: Department of Health Sciences Education Development, School of Public Health, Tehran UMS, Tehran, Iran – sequence: 6 givenname: Azita surname: Hekmatdoost fullname: Hekmatdoost, Azita organization: Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Shahid Beheshti UMS, Tehran, Iran – sequence: 7 givenname: Zahra surname: Mohammadi fullname: Mohammadi, Zahra organization: Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – sequence: 8 givenname: Zahra surname: Mahmoudi fullname: Mahmoudi, Zahra organization: Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – sequence: 9 givenname: Amaneh surname: Shayanrad fullname: Shayanrad, Amaneh organization: Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – sequence: 10 givenname: Farzin surname: Roozafzai fullname: Roozafzai, Farzin organization: Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – sequence: 11 givenname: Mahdi surname: Sheikh fullname: Sheikh, Mahdi organization: Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – sequence: 12 givenname: Alireza surname: Jalaeikhoo fullname: Jalaeikhoo, Alireza organization: Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences – sequence: 13 givenname: Mohammad Hossein surname: Somi fullname: Somi, Mohammad Hossein organization: Liver and Gastrointestinal Diseases Research Center, Tabriz UMS, Tabriz, Iran – sequence: 14 givenname: Fariborz surname: Mansour-Ghanaei fullname: Mansour-Ghanaei, Fariborz organization: Department of Gastroenterology, Gastrointestinal and Liver Diseases Research Center, Guilan UMS, Rasht, Iran – sequence: 15 givenname: Farid surname: Najafi fullname: Najafi, Farid organization: Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah UMS, Kermanshah, Iran – sequence: 16 givenname: Ehsan surname: Bahramali fullname: Bahramali, Ehsan organization: Noncommunicable Diseases Research Center, Fasa UMS, Fasa, Iran – sequence: 17 givenname: Amirhoushang surname: Mehrparvar fullname: Mehrparvar, Amirhoushang organization: Department of Occupational Medicine, Faculty of Medicine, Shahid Sadoughi UMS, Yazd, Iran – sequence: 18 givenname: Alireza surname: Ansari-Moghaddam fullname: Ansari-Moghaddam, Alireza organization: Health Promotion Research Center, Zahedan UMS, Zahedan, Iran – sequence: 19 givenname: Ahmad Ali surname: Enayati fullname: Enayati, Ahmad Ali organization: School of Public Health and Health Sciences Research Center, Mazandaran UMS, Sari, Iran – sequence: 20 givenname: Ali surname: Esmaeili Nadimi fullname: Esmaeili Nadimi, Ali organization: Department of Cardiology, School of Medicine, Rafsanjan UMS, Rafsanjan, Iran – sequence: 21 givenname: Abbas surname: Rezaianzadeh fullname: Rezaianzadeh, Abbas organization: Department of Epidemiology, School of Health, Shiraz UMS, Shiraz, Iran – sequence: 22 givenname: Nader surname: Saki fullname: Saki, Nader organization: Department of Otolaryngology, Head and Neck Surgery, Hearing and Speech Research Center, Ahvaz Jundishapur UMS, Ahvaz, Iran – sequence: 23 givenname: Fatemeh surname: Alipour fullname: Alipour, Fatemeh organization: Eye Research Center, Farabi Eye Hospital, Tehran UMS, Tehran, Iran – sequence: 24 givenname: Roya surname: Kelishadi fullname: Kelishadi, Roya organization: Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan UMS, Isfahan, Iran – sequence: 25 givenname: Afarin surname: Rahimi-Movaghar fullname: Rahimi-Movaghar, Afarin organization: Iranian National Center for Addiction Studies, Tehran UMS, Tehran, Iran – sequence: 26 givenname: Nayyereh surname: Aminisani fullname: Aminisani, Nayyereh organization: Department of Statistics and Epidemiology, Faculty of Health Sciences, Tabriz UMS, Tabriz, Iran – sequence: 27 givenname: Paolo surname: Boffetta fullname: Boffetta, Paolo organization: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York – sequence: 28 givenname: Reza surname: Malekzadeh fullname: Malekzadeh, Reza email: dr.reza.malekzadeh@gmail.com organization: Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran UMS, Tehran, Iran
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29145581$$D View this record in MEDLINE/PubMed
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Copyright	The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2018 The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2018
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Snippet	Abstract Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors... Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors associated... Noncommunicable diseases (NCDs) account for 76% of deaths in Iran, and this number is on the rise, in parallel with global rates. Many risk factors associated...
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SubjectTerms	Cohort analysis Epidemiology Health risk assessment Medical research Minority & ethnic groups Population studies Quality assurance Risk analysis Risk factors Studies Study Design Urine
Title	Prospective Epidemiological Research Studies in Iran (the PERSIAN Cohort Study): Rationale, Objectives, and Design
URI	https://www.ncbi.nlm.nih.gov/pubmed/29145581 https://www.proquest.com/docview/2306248997 https://search.proquest.com/docview/1966235547 https://pubmed.ncbi.nlm.nih.gov/PMC6279089
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