Modification of solid lipid nanoparticles loaded with nebivolol hydrochloride for improvement of oral bioavailability in treatment of hypertension: polyethylene glycol versus chitosan oligosaccharide lactate

Nebivolol (NB)-loaded solid lipid nanoparticles (SLNs) were prepared and modified with chitosan oligosaccharide lactate (COL) and polyethylene glycol (PEG) stearate for improvement of its oral bioavailability. Compritol, poloxamer and lecithin were used for the preparation of SLNs by homogenisation...

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Bibliographic Details
Published in:	Journal of microencapsulation Vol. 33; no. 1; pp. 30 - 42
Main Authors:	Üstündağ-Okur, Neslihan, Yurdasiper, Aysu, Gündoğdu, Evren, Homan Gökçe, Evren
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02-01-2016
Subjects:	Administration, Oral Caco-2 Cells cell culture Chitosan - chemistry Chitosan - pharmacokinetics Chitosan - pharmacology Encapsulation Humans Hypertension - drug therapy Nanoparticles - chemistry Nebivolol - chemistry Nebivolol - pharmacokinetics Nebivolol - pharmacology Oligosaccharides - chemistry Oligosaccharides - pharmacokinetics Oligosaccharides - pharmacology permeation Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - pharmacology Encapsulation cell culture permeation
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