Cysteine string protein 1 (CSP1) modulates insulin sensitivity by attenuating glucose transporter 4 (GLUT4) vesicle docking with the plasma membrane

Insulin stimulates glucose transporter 4 (GLUT4) vesicle recruitment from its intracellular storage site to the plasma membrane. Cysteine string protein 1 (CSP1) is a SNARE-binding protein involved in the vesicular trafficking of neurotransmitters and other exocytic processes. In this study, we inve...

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Bibliographic Details
Published in:	The Journal of Medical Investigation Vol. 60; no. 3.4; pp. 197 - 204
Main Authors:	Jambaldorj, Bayasgalan, Terada, Eri, Hosaka, Toshio, Kishuku, Yuka, Tomioka, Yukiko, Iwashima, Kaori, Hirata, Yohko, Teshigawara, Kiyoshi, Le, Chung Thi Kim, Nakagawa, Tadahiko, Harada, Nagakatsu, Sakai, Tohru, Sakaue, Hiroshi, Matsumoto, Toshio, Funaki, Makoto, Takahashi, Akira, Nakaya, Yutaka
Format:	Journal Article
Language:	English
Published:	Japan The University of Tokushima Faculty of Medicine 2013
Subjects:	3T3-L1 Cells Adipocytes - metabolism Animals Cell Membrane - metabolism cysteine string protein 1 Gene Knockdown Techniques Glucose Transporter Type 4 - metabolism GLUT4 HSP40 Heat-Shock Proteins - antagonists & inhibitors HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism Insulin Resistance - physiology Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism Mice Qa-SNARE Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism SNARE Up-Regulation VAMP2 Vesicle-Associated Membrane Protein 2 - metabolism
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