Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis

Asbestos causes asbestosis and various malignancies by mechanisms that are not clearly defined. Here, we review the accumulating evidence showing that asbestos is directly genotoxic by inducing DNA strand breaks (DNA-SB) and apoptosis in relevant lung target cells. Although the exact mechanisms by w...

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Bibliographic Details
Published in:	Experimental biology and medicine (Maywood, N.J.) Vol. 228; no. 6; p. 650
Main Authors:	Upadhyay, Daya, Kamp, David W
Format:	Journal Article
Language:	English
Published:	England 01-06-2003
Subjects:	Animals Apoptosis - drug effects Apoptosis - physiology Asbestos - adverse effects Asbestos - chemistry Asbestosis - epidemiology Asbestosis - etiology Asbestosis - genetics Asbestosis - pathology DNA Damage - physiology DNA Repair Enzyme Activation - drug effects Enzymes - metabolism Humans Iron - metabolism Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Oxidative Stress Reactive Nitrogen Species - metabolism Reactive Oxygen Species - metabolism Transcription Factors - metabolism
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