Epigenetics changes associated to environmental triggers in autoimmunity

Autoimmune diseases (AIDs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens and represent a heterogeneous group of disorders that affect specific target organs or multiple organs in different systems. While the pathogenesis of AID remains unclear, its aetiolog...

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Published in:	Autoimmunity (Chur, Switzerland) Vol. 49; no. 1; pp. 1 - 11
Main Authors:	Cañas, Carlos A., Cañas, Felipe, Bonilla-Abadía, Fabio, Ospina, Fabio E., Tobón, Gabriel J.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02-01-2016
Subjects:	Autoantibodies - genetics Autoantigens - genetics Autoimmunity - genetics Chromatin - chemistry Chromatin - immunology Chromatin modification DNA Methylation Epigenesis, Genetic - immunology Gene-Environment Interaction Genetic Predisposition to Disease Histones - genetics Histones - immunology Humans Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology RNA interference RNA Interference - immunology Signal Transduction systemic lupus erythematous UV light DNA methylation RNA interference systemic lupus erythematous UV light Chromatin modification
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Abstract	Autoimmune diseases (AIDs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens and represent a heterogeneous group of disorders that affect specific target organs or multiple organs in different systems. While the pathogenesis of AID remains unclear, its aetiology is multifunctional and includes a combination of genetic, epigenetic, immunological and environmental factors. In AIDs, several epigenetic mechanisms are defective including DNA demethylation, abnormal chromatin positioning associated with autoantibody production and abnormalities in the expression of RNA interference (RNAi). It is known that environmental factors may interfere with DNA methylation and histone modifications, however, little is known about epigenetic changes derived of regulation of RNAi. An approach to the known environmental factors and the mechanisms that alter the epigenetic regulation in AIDs (with emphasis in systemic lupus erythematosus, the prototype of systemic AID) are showed in this review.
AbstractList	Autoimmune diseases (AIDs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens and represent a heterogeneous group of disorders that affect specific target organs or multiple organs in different systems. While the pathogenesis of AID remains unclear, its aetiology is multifunctional and includes a combination of genetic, epigenetic, immunological and environmental factors. In AIDs, several epigenetic mechanisms are defective including DNA demethylation, abnormal chromatin positioning associated with autoantibody production and abnormalities in the expression of RNA interference (RNAi). It is known that environmental factors may interfere with DNA methylation and histone modifications, however, little is known about epigenetic changes derived of regulation of RNAi. An approach to the known environmental factors and the mechanisms that alter the epigenetic regulation in AIDs (with emphasis in systemic lupus erythematosus, the prototype of systemic AID) are showed in this review.
Author	Cañas, Carlos A. Ospina, Fabio E. Cañas, Felipe Bonilla-Abadía, Fabio Tobón, Gabriel J.
Author_xml	– sequence: 1 givenname: Carlos A. surname: Cañas fullname: Cañas, Carlos A. email: cacd12@hotmail.com organization: Department of Internal Medicine, Division of Rheumatology, Fundación Valle del Lili – sequence: 2 givenname: Felipe surname: Cañas fullname: Cañas, Felipe organization: Department of Internal Medicine, Fundación Valle del Lili, Cali, CES University School of Medicine – sequence: 3 givenname: Fabio surname: Bonilla-Abadía fullname: Bonilla-Abadía, Fabio organization: Department of Internal Medicine, Division of Rheumatology, Fundación Valle del Lili – sequence: 4 givenname: Fabio E. surname: Ospina fullname: Ospina, Fabio E. organization: Department of Internal Medicine, Division of Rheumatology, Fundación Valle del Lili – sequence: 5 givenname: Gabriel J. surname: Tobón fullname: Tobón, Gabriel J. organization: Department of Internal Medicine, Division of Rheumatology, Fundación Valle del Lili
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26369426$$D View this record in MEDLINE/PubMed
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Snippet	Autoimmune diseases (AIDs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens and represent a heterogeneous group of...
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SubjectTerms	Autoantibodies - genetics Autoantigens - genetics Autoimmunity - genetics Chromatin - chemistry Chromatin - immunology Chromatin modification DNA Methylation Epigenesis, Genetic - immunology Gene-Environment Interaction Genetic Predisposition to Disease Histones - genetics Histones - immunology Humans Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology RNA interference RNA Interference - immunology Signal Transduction systemic lupus erythematous UV light
Title	Epigenetics changes associated to environmental triggers in autoimmunity
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