Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis

Arachidonic acid (AA) and its metabolites have recently generated a heightened interest due to growing evidence of their significant role in cancer biology. Thus, inhibitors of the AA cascade, first and foremost COX inhibitors, which have originally been of interest in the treatment of inflammatory...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 9; no. 6; pp. 701 - 715
Main Authors:	Hyde, C.A.C., Missailidis, S.
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier B.V 01-06-2009 Elsevier
Subjects:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Arachidonic acid Arachidonic Acid - antagonists & inhibitors Arachidonic Acid - metabolism Aspirin - chemistry Aspirin - therapeutic use Biological and medical sciences Cancer Cell Cycle Proteins - metabolism Cell Proliferation - drug effects COX inhibitors Cyclooxygenase 2 - drug effects CYP450 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - therapeutic use Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - therapeutic use Humans LOX inhibitors Medical sciences Neoplasms - blood supply Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Pharmacology. Drug treatments Pyrazoles - pharmacology LOX inhibitors Arachidonic acid CYP450 COX inhibitors Cancer Cell proliferation Angiogenesis Inhibitor Neovascularization Malignant tumor Pharmacokinetics Metabolism
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