Creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients

• Published in: Applied physiology, nutrition, and metabolism Vol. 36; no. 5; p. 764
• Main Authors: Gualano, Bruno, Lugaresi, Rebeca, de Salles Painelli, Vitor, Painelli de Salles, Vitor, Queiroz, Andréia Cristina Carrenho, Artioli, Guilherme, Roschel, Hamilton, Otaduy, Maria Concepción, Leite, Cláudia da Costa, Lancha, Jr, Antonio Herbert
• Format: Journal Article
• Language: English
• Published: Canada 01-10-2011
• Subjects: Body Mass Index; Creatine - metabolism; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - therapy; Dietary Supplements; Double-Blind Method; Exercise; Female; Humans; Leg; Magnetic Resonance Spectroscopy; Male; Middle Aged; Muscle Fibers, Fast-Twitch - metabolism; Muscle Fibers, Slow-Twitch - metabolism; Muscle, Skeletal - metabolism
• ISSN: 1715-5312
• DOI: 10.1139/h11-083

We examined whether creatine supplementation affects muscle carnosine content in type 2 diabetic patients. Subjects were randomly assigned to receive either creatine (5 g·day(-1)) or placebo in a double-blind fashion. At baseline and after 12 weeks, carnosine content was evaluated in gastrocnemius and soleus muscles by using a 1H-MRS technique. No changes were found in gastrocnemius (p = 0.81) and soleus (p = 0.85). We concluded that creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients.