Epidemiology of Invasive Candidiasis

• Published in: Clinical epidemiology Vol. 16; pp. 549 - 566
• Main Authors: Bays, Derek J, Jenkins, Emily N, Lyman, Meghan, Chiller, Tom, Strong, Nora, Ostrosky-Zeichner, Luis, Hoenigl, Martin, Pappas, Peter G, Thompson Iii, George R
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 31-08-2024; Dove; Dove Medical Press
• Subjects: candida; Candidiasis; Drug resistance; emerging; Epidemiology; Health aspects; Infection; non-albicans candida species; Posaconazole; Prevention; resistance; Review; China; South Asia; epidemiology; non-albicans Candida species; Candida; emerging; resistance
• ISSN: 1179-1349; 1179-1349
• DOI: 10.2147/CLEP.S459600

Invasive candidiasis (IC) is an increasingly prevalent, costly, and potentially fatal infection brought on by the opportunistic yeast,
. Previously, IC has predominantly been caused by
which is often drug susceptible. There has been a global trend towards decreasing rates of infection secondary to
and a rise in non-
species with a corresponding increase in drug resistance creating treatment challenges. With advances in management of malignancies, there has also been an increase in the population at risk from IC along with a corresponding increase in incidence of breakthrough IC infections. Additionally, the emergence of
creates many challenges in management and prevention due to drug resistance and the organism's ability to transmit rapidly in the healthcare setting. While the development of novel antifungals is encouraging for future management, understanding the changing epidemiology of IC is a vital step in future management and prevention.