Submicromolar, Selective G-Quadruplex Ligands from One Pot: Thermodynamic and Structural Studies of Human Telomeric DNA Binding by Azacyanines

Bound to work: A molecular architecture with a shape that is slightly larger than a Watson–Crick base pair was investigated as a potential G‐quadruplex ligand. Azacyanines, which possess this architecture, were found to bind on the end of the quadruplex stack (as shown in the figure) and to exhibit...

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Published in:	Chembiochem : a European journal of chemical biology Vol. 9; no. 12; pp. 1889 - 1892
Main Authors:	Persil Çetinkol, Özgül, Engelhart, Aaron E, Nanjunda, Rupesh K, Wilson, W. David, Hud, Nicholas V
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley-VCH Verlag 11-08-2008 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects:	Animals Aza Compounds - chemistry Aza Compounds - metabolism Base Sequence cancer Cattle DNA - chemistry DNA - genetics DNA - metabolism DNA structures drug design G-Quadruplexes Humans Ligands quadruplexes Spectrometry, Fluorescence Substrate Specificity Telomere - genetics telomeres Thermodynamics
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Abstract	Bound to work: A molecular architecture with a shape that is slightly larger than a Watson–Crick base pair was investigated as a potential G‐quadruplex ligand. Azacyanines, which possess this architecture, were found to bind on the end of the quadruplex stack (as shown in the figure) and to exhibit high selectivity over duplex binding. The chemical properties, ease of synthesis, and great potential for modification make the azacyanines and their analogues attractive for development as G‐quadruplex ligands in drug development.
AbstractList	Bound to work: A molecular architecture with a shape that is slightly larger than a Watson–Crick base pair was investigated as a potential G‐quadruplex ligand. Azacyanines, which possess this architecture, were found to bind on the end of the quadruplex stack (as shown in the figure) and to exhibit high selectivity over duplex binding. The chemical properties, ease of synthesis, and great potential for modification make the azacyanines and their analogues attractive for development as G‐quadruplex ligands in drug development.
Author	Nanjunda, Rupesh K. Hud, Nicholas V. Wilson, W. David Engelhart, Aaron E. Persil Çetinkol, Özgül
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18600816$$D View this record in MEDLINE/PubMed
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Cites_doi	10.4161/cc.3.9.1152 10.1021/jm0203377 10.1002/anie.200705589 10.1002/1097-0282(2000/2001)56:3<123::AID-BIP10010>3.0.CO;2-3 10.1021/ja065591t 10.1021/jo001484k 10.1021/ja062791w 10.1093/nar/gkg648 10.1146/annurev.pharmtox.43.100901.135733 10.1016/S1471-4892(02)00182-0 10.1016/j.bmcl.2004.09.037 10.1007/s10616-004-5127-z 10.1093/nar/gkm009 10.1093/nar/29.5.1087 10.1016/S0040-4039(00)00908-4 10.1016/j.bpc.2006.06.006 10.1073/pnas.0707365104 10.1529/biophysj.106.097246 10.1039/b709898g 10.1021/ja0492891 10.1073/pnas.182256799 10.1021/ja984153m 10.1093/nar/30.4.983 10.1021/ja030403
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SubjectTerms	Animals Aza Compounds - chemistry Aza Compounds - metabolism Base Sequence cancer Cattle DNA - chemistry DNA - genetics DNA - metabolism DNA structures drug design G-Quadruplexes Humans Ligands quadruplexes Spectrometry, Fluorescence Substrate Specificity Telomere - genetics telomeres Thermodynamics
Title	Submicromolar, Selective G-Quadruplex Ligands from One Pot: Thermodynamic and Structural Studies of Human Telomeric DNA Binding by Azacyanines
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