Cytotoxic T lymphocyte associated antigen-4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis

• Published in: European journal of neurology Vol. 15; no. 8; pp. 862 - 864
• Main Authors: Haghighi, A. Borhani, Ghahramani, S., Azarpira, N., Pourjafar, M., Nikseresht, A. R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-08-2008
• Subjects: Adult; Antigens, CD - genetics; CTLA-4 Antigen; cytotoxic T lymphocyte antigen-4; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Iran; Male; multiple sclerosis; Multiple Sclerosis - genetics; Polymerase Chain Reaction; polymorphism; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Iran
• ISSN: 1351-5101; 1468-1331
• DOI: 10.1111/j.1468-1331.2008.02153.x

Background:  Cytotoxic T lymphocyte antigen‐4 (CTLA‐4) is a T‐cell surface receptor of activated T cells.
Material and methods:  We studied 100 Iranian patients with clinically definite multiple sclerosis (MS) and 100 ethnic, sex‐ and age‐matched controls. CTLA‐4 exon 1 A/G polymorphism was compared amongst patients and controls.
Results:  There was no statistically significant difference in the allelic [odds ratio (OR): 1.19, confidence interval (CI) 95%: 0.76–1.85, P = 0.4] and genotypes (OR: 1.60, CI 95%: 0.911–2.824, P = 0.102) distribution amongst patients and controls. Also gender, course and progression index did not reveal any statistically significant differences in allele and genotype distribution of A/G polymorphism.
Conclusion:  As a non‐European patient population, our results are consistent with the major previous studies showing no significant associations between CTLA4 exon 1 polymorphism and neither MS nor any of its subtypes.