Reversible binding of anthracycline antibiotics to erythrocytes treated with glutaraldehyde

Human erythrocytes treated with glutaraldehyde can take up anthracycline antibiotics (daunorubicin and doxorubicin) from the incubation medium and do so faster than untreated cells. The antibiotics are readily released when the suspending medium is replaced with an antibiotic-free one. Our findings...

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Bibliographic Details
Published in:	Biotechnology and applied biochemistry Vol. 24; no. 3; p. 241
Main Authors:	Ataullakhanov, F I, Kulikova, E V, Vitvitsky, V M
Format:	Journal Article
Language:	English
Published:	United States 01-12-1996
Subjects:	Antibiotics, Antineoplastic - blood Antibiotics, Antineoplastic - pharmacokinetics Cell Membrane Permeability - drug effects Daunorubicin - blood Daunorubicin - pharmacokinetics Doxorubicin - blood Doxorubicin - pharmacokinetics Erythrocytes - drug effects Erythrocytes - metabolism Glutaral - pharmacology Humans
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Summary:	Human erythrocytes treated with glutaraldehyde can take up anthracycline antibiotics (daunorubicin and doxorubicin) from the incubation medium and do so faster than untreated cells. The antibiotics are readily released when the suspending medium is replaced with an antibiotic-free one. Our findings provide evidence that glutaraldehyde-treated erythrocytes remain capable of reversible binding of anthracycline antibiotics.
ISSN:	0885-4513
DOI:	10.1111/j.1470-8744.1996.tb00401.x