Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model

Highlights • TRPM7 increases after injections of 6-hydroxydopamine into the striatum. • Carvacrol reduces the loss of dopaminergic neurons induced by 6-hydroxydopamine. • Caspase-3 upregulation after 6-hydroxydopamine is attenuated by carvacrol. • Asymmetrical use of the forelimbs after 6-hydroxydop...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience Vol. 356; pp. 176 - 181
Main Authors:	Dati, L.M, Ulrich, H, Real, C.C, Feng, Z.P, Sun, H.S, Britto, L.R
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 25-07-2017
Subjects:	Animals carvacrol Disease Models, Animal dopamine Male Mice, Inbred C57BL Monoterpenes - pharmacology Neurology Neurons - drug effects Neurons - metabolism neuroprotection Neuroprotection - drug effects Neuroprotective Agents - pharmacology Parkinson Disease - drug therapy Substantia Nigra - drug effects TRP channels analysis of variance ANOVA neuroprotection PFA SEM standard error of the mean carvacrol paraformaldehyde dopamine TRP channels
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Highlights • TRPM7 increases after injections of 6-hydroxydopamine into the striatum. • Carvacrol reduces the loss of dopaminergic neurons induced by 6-hydroxydopamine. • Caspase-3 upregulation after 6-hydroxydopamine is attenuated by carvacrol. • Asymmetrical use of the forelimbs after 6-hydroxydopamine was reduced by carvacrol.
AbstractList	Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models of neurodegeneration, including ischemia, epilepsy and traumatic neuronal injury. In this study, we investigated the effects of carvacrol (i.p.) upon the neurodegeneration induced by 6-hydroxy-dopamine unilateral intrastriatal injections in mice. We have also used the cylinder test to assess the behavioral effects of carvacrol in that model of Parkinson's disease, and immunoblots to evaluate the levels of caspase-3 and TRPM7, one of major targets of carvacrol. Behavioral testing revealed that carvacrol largely reduced the asymmetrical use of the forelimbs induced by unilateral 6-hydroxy-dopamine. Carvacrol dramatically reduced the loss of tyrosine hydroxylase immunostaining both in the substantia nigra and in the striatum that are typical of the model. Immunoblots for tyrosine hydroxylase confirmed this effect. Caspase-3 levels were very high after toxin injections, but carvacrol appeared to reduce them to control levels. Finally, TRPM7, observed by immunoblots, increased after 6-hydroxy-dopamine, suggesting the involvement of this cation channel in the ensuing neurodegenerative process. The present data suggest that carvacrol promotes a marked neuroprotection in the 6-hydroxy-dopamine model of Parkinson's disease, possibly by its non-specific blocking effect upon TRPM7 channels. Highlights • TRPM7 increases after injections of 6-hydroxydopamine into the striatum. • Carvacrol reduces the loss of dopaminergic neurons induced by 6-hydroxydopamine. • Caspase-3 upregulation after 6-hydroxydopamine is attenuated by carvacrol. • Asymmetrical use of the forelimbs after 6-hydroxydopamine was reduced by carvacrol. •TRPM7 increases after injections of 6-hydroxydopamine into the striatum.•Carvacrol reduces the loss of dopaminergic neurons induced by 6-hydroxydopamine.•Caspase-3 upregulation after 6-hydroxydopamine is attenuated by carvacrol.•Asymmetrical use of the forelimbs after 6-hydroxydopamine was reduced by carvacrol. Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models of neurodegeneration, including ischemia, epilepsy and traumatic neuronal injury. In this study, we investigated the effects of carvacrol (i.p.) upon the neurodegeneration induced by 6-hydroxy-dopamine unilateral intrastriatal injections in mice. We have also used the cylinder test to assess the behavioral effects of carvacrol in that model of Parkinson’s disease, and immunoblots to evaluate the levels of caspase-3 and TRPM7, one of major targets of carvacrol. Behavioral testing revealed that carvacrol largely reduced the asymmetrical use of the forelimbs induced by unilateral 6-hydroxy-dopamine. Carvacrol dramatically reduced the loss of tyrosine hydroxylase immunostaining both in the substantia nigra and in the striatum that are typical of the model. Immunoblots for tyrosine hydroxylase confirmed this effect. Caspase-3 levels were very high after toxin injections, but carvacrol appeared to reduce them to control levels. Finally, TRPM7, observed by immunoblots, increased after 6-hydroxy-dopamine, suggesting the involvement of this cation channel in the ensuing neurodegenerative process. The present data suggest that carvacrol promotes a marked neuroprotection in the 6-hydroxy-dopamine model of Parkinson’s disease, possibly by its non-specific blocking effect upon TRPM7 channels.
Author	Feng, Z.P Britto, L.R Real, C.C Sun, H.S Dati, L.M Ulrich, H
Author_xml	– sequence: 1 fullname: Dati, L.M – sequence: 2 fullname: Ulrich, H – sequence: 3 fullname: Real, C.C – sequence: 4 fullname: Feng, Z.P – sequence: 5 fullname: Sun, H.S – sequence: 6 fullname: Britto, L.R
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28526576$$D View this record in MEDLINE/PubMed
BookMark	eNqNkU9rGzEQxUVJaJw_X6EsPfWym5G0Wsk9BIrbNAFDDmnPQtbOEjm7kiPtGvztI9duKTlFFyHx5s2b35yTEx88EvKZQkWBNtfryuMUQ7IOvcWKAZUViAoo_0BmVEleSlHXJ2QGHJqyFoydkfOU1pCPqPlHcsaUYI2QzYzcLkzcGhtDX2xiGMKIqfjjnl8j2tEFXzhfjE9YDGFKWDzh4DYmPjufgnfG5-8W-0ty2pk-4dXxviC_b3_8WtyVy4ef94tvy9LWXIxl11Leqi7HUFwoy-aNYIZLJiR2UCODOQjOamtWYOwKEISslVIrxaxsWcv4Bfly8M3xXiZMox5cstj3xmOOp-kcQHEmgWfp14M0D5dSxE5vohtM3GkKes9Rr_X_HPWeowahM8dc_OnYZ1oN2P4r_QsuC74fBJin3TqM-mjTupix6Ta49_W5eWNje-edNf0z7jCtwxR95qmpTkyDftxvdL9QKnkesWn4K_0Cocg
CitedBy_id	crossref_primary_10_1080_07391102_2019_1590243 crossref_primary_10_1371_journal_pone_0246003 crossref_primary_10_1007_s12640_019_00144_5 crossref_primary_10_1080_07391102_2022_2086923 crossref_primary_10_3390_ijms232213840 crossref_primary_10_1016_j_biopha_2022_113611 crossref_primary_10_3390_ijms21217897 crossref_primary_10_1016_j_neuint_2019_02_021 crossref_primary_10_1007_s00210_019_01754_8 crossref_primary_10_3390_ijms24010223 crossref_primary_10_3390_ijms24076073 crossref_primary_10_1111_bcpt_13282 crossref_primary_10_1134_S181971242402003X crossref_primary_10_1007_s10973_022_11327_2 crossref_primary_10_1590_0004_282x20190079 crossref_primary_10_2174_1871527320666210506185042 crossref_primary_10_2174_1570159X16666180905094123 crossref_primary_10_1016_j_ceca_2024_102886 crossref_primary_10_1007_s00210_019_01793_1 crossref_primary_10_2174_1871520621666210901111932 crossref_primary_10_5897_JPP2017_0467 crossref_primary_10_1007_s12640_023_00660_5 crossref_primary_10_1016_j_exer_2024_109938 crossref_primary_10_1016_j_aca_2018_08_061 crossref_primary_10_1007_s00213_023_06487_4 crossref_primary_10_1016_j_phymed_2020_153422 crossref_primary_10_1111_cns_14459 crossref_primary_10_1007_s12264_024_01242_x crossref_primary_10_1016_j_lfs_2019_116795 crossref_primary_10_1109_JSEN_2022_3159026 crossref_primary_10_1111_ejn_15565 crossref_primary_10_3390_biom9120835 crossref_primary_10_1007_s11011_018_0314_3 crossref_primary_10_1016_j_expneurol_2024_114780 crossref_primary_10_1016_j_brainres_2024_148954 crossref_primary_10_1002_cbin_12048 crossref_primary_10_1007_s12640_019_00088_w crossref_primary_10_2174_1570159X21666221223120251 crossref_primary_10_1007_s12035_022_02723_8 crossref_primary_10_3390_cells7120231 crossref_primary_10_1016_j_biopha_2020_109825 crossref_primary_10_3390_ijms23105470
Cites_doi	10.1016/j.biocel.2010.04.006 10.1038/nn.2395 10.1186/gb-2011-12-3-218 10.1016/j.bbrc.2015.05.007 10.1016/j.ydbio.2013.11.015 10.1007/978-94-007-0265-3_29 10.1155/2015/379817 10.1194/jlr.M900255-JLR200 10.1016/j.tips.2004.10.004 10.1080/19336950.2015.1075675 10.1016/j.ceca.2016.02.012 10.1371/journal.pone.0033584 10.1007/s00441-004-0938-y 10.1016/j.bbr.2011.09.025 10.1073/pnas.040556597 10.1007/978-3-540-34891-7_19 10.1186/s13041-015-0102-5 10.1085/jgp.200509410 10.1007/978-3-642-54215-2_21 10.1016/j.ceca.2008.11.009 10.2174/1568026611313030009 10.1016/j.neuint.2015.07.020 10.18632/oncotarget.3872 10.1111/epi.13645 10.1016/j.bbr.2011.12.007 10.1016/j.pharmthera.2015.05.006 10.1016/S0092-8674(03)01017-1 10.1016/j.neulet.2012.09.044 10.1007/s12035-014-9032-y 10.1371/journal.pone.0075532
ContentType	Journal Article
Copyright	IBRO 2017 IBRO Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
Copyright_xml	– notice: IBRO – notice: 2017 IBRO – notice: Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8
DOI	10.1016/j.neuroscience.2017.05.013
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology
EISSN	1873-7544
EndPage	181
ExternalDocumentID	10_1016_j_neuroscience_2017_05_013 28526576 S0306452217303366 1_s2_0_S0306452217303366
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K --M -DZ -~X .1- .55 .FO .GJ .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 29N 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXKI AAXLA AAXUO ABCQJ ABFNM ABFRF ABJNI ABLJU ABMAC ABTEW ABXDB ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFJKZ AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMQ HVGLF HZ~ IHE J1W KOM L7B M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OP~ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SNS SPCBC SSN SSZ T5K UNMZH WUQ X7M YYP Z5R ZGI ZXP ~G- AADPK AAIAV ABYKQ AJBFU EFLBG CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8
ID	FETCH-LOGICAL-c435t-fd13d8f0058358c29652a37257ef04e20905324cab0acb0e0574888b82c7d2d23
ISSN	0306-4522
IngestDate	Fri Oct 25 03:14:50 EDT 2024 Thu Sep 26 17:04:20 EDT 2024 Wed Oct 16 00:59:49 EDT 2024 Fri Feb 23 02:29:37 EST 2024 Tue Oct 15 22:56:03 EDT 2024
IsPeerReviewed	true
IsScholarly	true
Keywords	analysis of variance ANOVA neuroprotection PFA SEM standard error of the mean carvacrol paraformaldehyde dopamine TRP channels
Language	English
License	Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c435t-fd13d8f0058358c29652a37257ef04e20905324cab0acb0e0574888b82c7d2d23
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	28526576
PQID	1900832703
PQPubID	23479
PageCount	6
ParticipantIDs	proquest_miscellaneous_1900832703 crossref_primary_10_1016_j_neuroscience_2017_05_013 pubmed_primary_28526576 elsevier_sciencedirect_doi_10_1016_j_neuroscience_2017_05_013 elsevier_clinicalkeyesjournals_1_s2_0_S0306452217303366
PublicationCentury	2000
PublicationDate	2017-07-25
PublicationDateYYYYMMDD	2017-07-25
PublicationDate_xml	– month: 07 year: 2017 text: 2017-07-25 day: 25
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Neuroscience
PublicationTitleAlternate	Neuroscience
PublicationYear	2017
Publisher	Elsevier Ltd
Publisher_xml	– name: Elsevier Ltd
References	Decker, McNeill, Lambert, Overton, Chen, Lorca, Johnson, Brockerhoff, Mohapatra, MacArthur, Panula, Masino, Runnels, Cornell (b0030) 2014; 386 Sun, Sukumaran, Schaar, Singh (b0140) 2015; 9 Paxinos, Franklin (b0115) 2001 Yu, Zhang, Chen, Pei, Hua, Qian, He, Liu, Xu (b0160) 2012; 7 Khan, Ahmad, Alshammari, Baig, Lohani, Somvanshi, Hague (b0075) 2015; 2015 Oz, Lozon, Sultan, Yang, Galadari (b0100) 2015; 152 Glajch, Fleming, Surmeier, Osten (b0050) 2012; 230 Hotta, Nakata, Katsukawa, Hori, Takahashi, Inoue (b0065) 2010; 51 Sukumaran, Schaar, Sun, Singh (b0130) 2016; 60 Aarts, Iihara, Wei, Xiong, Arundine, Cerwinski, Macdonald, Tymianski (b0005) 2003; 115 Smith, Heuer, Dunnett, Lane (b0125) 2012; 226 Verma, Quillinan, Yang, Nakayama, Cheng, Kelley, Herson (b0155) 2012; 530 Dadon, Minke (b0025) 2010; 42 Schober (b0120) 2004; 318 Hartmann, Hunot, Michel, Muriel, Vyas, Faucheux, Mouatt-Prigent, Turmel, Srinivasan, Ruberg, Evan, Agid, Hirsch (b0055) 2000; 97 Chen, Xu, Xiao, Liu, Fang, Liu, Turlova, Barszczyk, Zhong, Sun, Britto, Feng, Sun (b0010) 2015; 8 Chen, Barszczyk, Turlova, Deurloo, Liu, Yang, Rutka, Feng, Sun (b0015) 2015; 6 Turlova, Bae, Deurloo, Chen, Barszczyk, Horgen, Fleig, Feng, Sun (b0150) 2016; 53 Hernandes, Santos, Café-Mendes, Lima, Scavone, Munhoz, Britto (b0060) 2013; 8 Penner, Fleig (b0110) 2007; 179 Sun, Jackson, Martin, Jansen, Teves, Cui, Kiyonaka, Mori, Jones, Forder, Golde, Orser, Macdonald, Tymianski (b0135) 2009; 12 Khalil, Kovac, Morris, Walker (b0070) 2017; 58 Cook, Heuvel, Vink (b0020) 2009; 22 Miller, Zhang (b0085) 2011; 704 Takada, Numata, Mori (b0145) 2013; 13 Fleig, Penner (b0045) 2004; 25 Oh, Chun, Park, Kim, Park, Chung (b0095) 2015; 463 Demeuse, Penner, Fleig (b0035) 2006; 127 Parnas, Peters, Dadon, Lev, Vertkin, Slutsky, Minke (b0105) 2009; 45 Li, Zhang, Zhou, Zhang, Liang, Liu, Wei, Li, Meng, Xia, Dan, Song (b0080) 2015; 90 Fleig, Chubanov (b0040) 2014; 222 Nilius, Owsianik (b0090) 2011; 12 Sukumaran (10.1016/j.neuroscience.2017.05.013_b0130) 2016; 60 Smith (10.1016/j.neuroscience.2017.05.013_b0125) 2012; 226 Khalil (10.1016/j.neuroscience.2017.05.013_b0070) 2017; 58 Parnas (10.1016/j.neuroscience.2017.05.013_b0105) 2009; 45 Demeuse (10.1016/j.neuroscience.2017.05.013_b0035) 2006; 127 Nilius (10.1016/j.neuroscience.2017.05.013_b0090) 2011; 12 Yu (10.1016/j.neuroscience.2017.05.013_b0160) 2012; 7 Turlova (10.1016/j.neuroscience.2017.05.013_b0150) 2016; 53 Hotta (10.1016/j.neuroscience.2017.05.013_b0065) 2010; 51 Oh (10.1016/j.neuroscience.2017.05.013_b0095) 2015; 463 Takada (10.1016/j.neuroscience.2017.05.013_b0145) 2013; 13 Hernandes (10.1016/j.neuroscience.2017.05.013_b0060) 2013; 8 Schober (10.1016/j.neuroscience.2017.05.013_b0120) 2004; 318 Sun (10.1016/j.neuroscience.2017.05.013_b0140) 2015; 9 Decker (10.1016/j.neuroscience.2017.05.013_b0030) 2014; 386 Oz (10.1016/j.neuroscience.2017.05.013_b0100) 2015; 152 Glajch (10.1016/j.neuroscience.2017.05.013_b0050) 2012; 230 Fleig (10.1016/j.neuroscience.2017.05.013_b0040) 2014; 222 Cook (10.1016/j.neuroscience.2017.05.013_b0020) 2009; 22 Li (10.1016/j.neuroscience.2017.05.013_b0080) 2015; 90 Dadon (10.1016/j.neuroscience.2017.05.013_b0025) 2010; 42 Aarts (10.1016/j.neuroscience.2017.05.013_b0005) 2003; 115 Verma (10.1016/j.neuroscience.2017.05.013_b0155) 2012; 530 Hartmann (10.1016/j.neuroscience.2017.05.013_b0055) 2000; 97 Khan (10.1016/j.neuroscience.2017.05.013_b0075) 2015; 2015 Penner (10.1016/j.neuroscience.2017.05.013_b0110) 2007; 179 Paxinos (10.1016/j.neuroscience.2017.05.013_b0115) 2001 Chen (10.1016/j.neuroscience.2017.05.013_b0015) 2015; 6 Fleig (10.1016/j.neuroscience.2017.05.013_b0045) 2004; 25 Sun (10.1016/j.neuroscience.2017.05.013_b0135) 2009; 12 Miller (10.1016/j.neuroscience.2017.05.013_b0085) 2011; 704 Chen (10.1016/j.neuroscience.2017.05.013_b0010) 2015; 8
References_xml	– volume: 51 start-page: 132 year: 2010 end-page: 139 ident: b0065 article-title: Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expression publication-title: J Lipid Res contributor: fullname: Inoue – volume: 463 start-page: 7 year: 2015 end-page: 12 ident: b0095 article-title: Regulation of basal autophagy by transient receptor potential melastatin 7 (TRPM7) channel publication-title: Biochem Biophys Res Commun contributor: fullname: Chung – volume: 386 start-page: 428 year: 2014 end-page: 439 ident: b0030 article-title: Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern publication-title: Dev Biol contributor: fullname: Cornell – volume: 12 start-page: 218 year: 2011 ident: b0090 article-title: The transient receptor potential family of ion channels publication-title: Genome Biol contributor: fullname: Owsianik – volume: 22 start-page: 188 year: 2009 end-page: 189 ident: b0020 article-title: Characterisation of TRPM channel mRNA levels in Parkinson disease. In: The 12th International Magnesium Symposium publication-title: Magnesium Res contributor: fullname: Vink – volume: 2015 start-page: 379817 year: 2015 ident: b0075 article-title: Implication of Caspase-3 as a common therapeutic target for multineurodegenerative disorders and its inhibition using nonpeptidyl natural compounds publication-title: Biomed Res Int contributor: fullname: Hague – volume: 53 start-page: 595 year: 2016 end-page: 610 ident: b0150 article-title: TRPM7 regulates axonal outgrowth and maturation of primary hippocampal neurons publication-title: Mol Neurobiol contributor: fullname: Sun – volume: 179 start-page: 313 year: 2007 end-page: 328 ident: b0110 article-title: The Mg2+ and Mg(2+)-nucleotide-regulated channel kinase TRPM7 publication-title: Handb Exp Pharmacol contributor: fullname: Fleig – volume: 60 start-page: 123 year: 2016 end-page: 132 ident: b0130 article-title: Functional role of TRP channels in modulating ER stress and autophagy publication-title: Cell Calcium contributor: fullname: Singh – volume: 7 start-page: e33584 year: 2012 ident: b0160 article-title: Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice publication-title: PLoS One contributor: fullname: Xu – volume: 42 start-page: 1430 year: 2010 end-page: 1445 ident: b0025 article-title: Cellular functions of transient receptor potential channels publication-title: Int J Biochem Cell Biol contributor: fullname: Minke – volume: 58 start-page: 263 year: 2017 end-page: 273 ident: b0070 article-title: Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death and cognitive decline publication-title: Epilepsia contributor: fullname: Walker – volume: 12 start-page: 1300 year: 2009 end-page: 1307 ident: b0135 article-title: Supression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia publication-title: Nat Neurosci contributor: fullname: Tymianski – volume: 704 start-page: 531 year: 2011 end-page: 544 ident: b0085 article-title: TRP channels as mediators of oxidative stress publication-title: Adv Exp Med Biol contributor: fullname: Zhang – volume: 6 start-page: 16321 year: 2015 end-page: 16340 ident: b0015 article-title: Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion publication-title: Oncotarget contributor: fullname: Sun – volume: 222 start-page: 521 year: 2014 end-page: 546 ident: b0040 article-title: TRPM7 publication-title: Handb Exp Pharmacol contributor: fullname: Chubanov – volume: 318 start-page: 215 year: 2004 end-page: 224 ident: b0120 article-title: Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP publication-title: Cell Tissue Res contributor: fullname: Schober – volume: 115 start-page: 863 year: 2003 end-page: 877 ident: b0005 article-title: A key role for TRPM7 channels in anoxic neuronal death publication-title: Cell contributor: fullname: Tymianski – volume: 90 start-page: 107 year: 2015 end-page: 113 ident: b0080 article-title: Carvacrol attenuates traumatic neuronal injury through store-operated Ca2+ entry-independent regulation of intracellular Ca2+ homeostasis publication-title: Neurochem Int contributor: fullname: Song – volume: 8 start-page: 11 year: 2015 ident: b0010 article-title: TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury publication-title: Mol Brain contributor: fullname: Sun – volume: 9 start-page: 253 year: 2015 end-page: 261 ident: b0140 article-title: TRPM7 and its role in neurodegenerative diseases publication-title: Channels contributor: fullname: Singh – volume: 8 start-page: e75532 year: 2013 ident: b0060 article-title: Microglial cells are involved in the susceptibility of NADPHoxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration publication-title: PLoS One contributor: fullname: Britto – year: 2001 ident: b0115 article-title: The mouse brain in stereotaxic coordinates contributor: fullname: Franklin – volume: 530 start-page: 41 year: 2012 end-page: 46 ident: b0155 article-title: TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death publication-title: Neurosci Lett contributor: fullname: Herson – volume: 25 start-page: 633 year: 2004 end-page: 639 ident: b0045 article-title: The TRPM ion channel subfamily: molecular, biophysical and functional features publication-title: Trends Pharmacol Sci contributor: fullname: Penner – volume: 127 start-page: 421 year: 2006 end-page: 434 ident: b0035 article-title: TRPM7 channel is regulated by magnesium nucleotides via its kinase domain publication-title: J Gen Physiol contributor: fullname: Fleig – volume: 230 start-page: 309 year: 2012 end-page: 316 ident: b0050 article-title: Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson’s disease publication-title: Behav Brain Res contributor: fullname: Osten – volume: 13 start-page: 332 year: 2013 end-page: 334 ident: b0145 article-title: Targeting TRPs in neurodegenerative disorders publication-title: Curr Top Med Chem contributor: fullname: Mori – volume: 45 start-page: 300 year: 2009 end-page: 309 ident: b0105 article-title: Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels publication-title: Cell Calcium contributor: fullname: Minke – volume: 226 start-page: 281 year: 2012 end-page: 292 ident: b0125 article-title: Unilateral nigrostriatal 6-hydroxydopamine lesions in mice. II: Predicting L-DOPA-induced dyskinesia publication-title: Behav Brain Res contributor: fullname: Lane – volume: 97 start-page: 2875 year: 2000 end-page: 2880 ident: b0055 article-title: Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson’s disease publication-title: Proc Natl Acad Sci USA contributor: fullname: Hirsch – volume: 152 start-page: 83 year: 2015 end-page: 97 ident: b0100 article-title: Effects of monoterpenes on ion channels of excitable cells publication-title: Pharmacol Ther contributor: fullname: Galadari – volume: 42 start-page: 1430 year: 2010 ident: 10.1016/j.neuroscience.2017.05.013_b0025 article-title: Cellular functions of transient receptor potential channels publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2010.04.006 contributor: fullname: Dadon – volume: 12 start-page: 1300 year: 2009 ident: 10.1016/j.neuroscience.2017.05.013_b0135 article-title: Supression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia publication-title: Nat Neurosci doi: 10.1038/nn.2395 contributor: fullname: Sun – volume: 12 start-page: 218 year: 2011 ident: 10.1016/j.neuroscience.2017.05.013_b0090 article-title: The transient receptor potential family of ion channels publication-title: Genome Biol doi: 10.1186/gb-2011-12-3-218 contributor: fullname: Nilius – volume: 463 start-page: 7 year: 2015 ident: 10.1016/j.neuroscience.2017.05.013_b0095 article-title: Regulation of basal autophagy by transient receptor potential melastatin 7 (TRPM7) channel publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2015.05.007 contributor: fullname: Oh – volume: 386 start-page: 428 year: 2014 ident: 10.1016/j.neuroscience.2017.05.013_b0030 article-title: Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern publication-title: Dev Biol doi: 10.1016/j.ydbio.2013.11.015 contributor: fullname: Decker – volume: 704 start-page: 531 year: 2011 ident: 10.1016/j.neuroscience.2017.05.013_b0085 article-title: TRP channels as mediators of oxidative stress publication-title: Adv Exp Med Biol doi: 10.1007/978-94-007-0265-3_29 contributor: fullname: Miller – volume: 2015 start-page: 379817 year: 2015 ident: 10.1016/j.neuroscience.2017.05.013_b0075 article-title: Implication of Caspase-3 as a common therapeutic target for multineurodegenerative disorders and its inhibition using nonpeptidyl natural compounds publication-title: Biomed Res Int doi: 10.1155/2015/379817 contributor: fullname: Khan – volume: 51 start-page: 132 year: 2010 ident: 10.1016/j.neuroscience.2017.05.013_b0065 article-title: Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expression publication-title: J Lipid Res doi: 10.1194/jlr.M900255-JLR200 contributor: fullname: Hotta – volume: 25 start-page: 633 year: 2004 ident: 10.1016/j.neuroscience.2017.05.013_b0045 article-title: The TRPM ion channel subfamily: molecular, biophysical and functional features publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2004.10.004 contributor: fullname: Fleig – volume: 9 start-page: 253 year: 2015 ident: 10.1016/j.neuroscience.2017.05.013_b0140 article-title: TRPM7 and its role in neurodegenerative diseases publication-title: Channels doi: 10.1080/19336950.2015.1075675 contributor: fullname: Sun – volume: 60 start-page: 123 issue: 2 year: 2016 ident: 10.1016/j.neuroscience.2017.05.013_b0130 article-title: Functional role of TRP channels in modulating ER stress and autophagy publication-title: Cell Calcium doi: 10.1016/j.ceca.2016.02.012 contributor: fullname: Sukumaran – volume: 7 start-page: e33584 year: 2012 ident: 10.1016/j.neuroscience.2017.05.013_b0160 article-title: Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice publication-title: PLoS One doi: 10.1371/journal.pone.0033584 contributor: fullname: Yu – volume: 318 start-page: 215 year: 2004 ident: 10.1016/j.neuroscience.2017.05.013_b0120 article-title: Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP publication-title: Cell Tissue Res doi: 10.1007/s00441-004-0938-y contributor: fullname: Schober – volume: 226 start-page: 281 year: 2012 ident: 10.1016/j.neuroscience.2017.05.013_b0125 article-title: Unilateral nigrostriatal 6-hydroxydopamine lesions in mice. II: Predicting L-DOPA-induced dyskinesia publication-title: Behav Brain Res doi: 10.1016/j.bbr.2011.09.025 contributor: fullname: Smith – volume: 97 start-page: 2875 year: 2000 ident: 10.1016/j.neuroscience.2017.05.013_b0055 article-title: Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson’s disease publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.040556597 contributor: fullname: Hartmann – volume: 179 start-page: 313 year: 2007 ident: 10.1016/j.neuroscience.2017.05.013_b0110 article-title: The Mg2+ and Mg(2+)-nucleotide-regulated channel kinase TRPM7 publication-title: Handb Exp Pharmacol doi: 10.1007/978-3-540-34891-7_19 contributor: fullname: Penner – volume: 8 start-page: 11 year: 2015 ident: 10.1016/j.neuroscience.2017.05.013_b0010 article-title: TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury publication-title: Mol Brain doi: 10.1186/s13041-015-0102-5 contributor: fullname: Chen – volume: 127 start-page: 421 year: 2006 ident: 10.1016/j.neuroscience.2017.05.013_b0035 article-title: TRPM7 channel is regulated by magnesium nucleotides via its kinase domain publication-title: J Gen Physiol doi: 10.1085/jgp.200509410 contributor: fullname: Demeuse – volume: 222 start-page: 521 year: 2014 ident: 10.1016/j.neuroscience.2017.05.013_b0040 article-title: TRPM7 publication-title: Handb Exp Pharmacol doi: 10.1007/978-3-642-54215-2_21 contributor: fullname: Fleig – volume: 45 start-page: 300 year: 2009 ident: 10.1016/j.neuroscience.2017.05.013_b0105 article-title: Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels publication-title: Cell Calcium doi: 10.1016/j.ceca.2008.11.009 contributor: fullname: Parnas – volume: 22 start-page: 188 year: 2009 ident: 10.1016/j.neuroscience.2017.05.013_b0020 article-title: Characterisation of TRPM channel mRNA levels in Parkinson disease. In: The 12th International Magnesium Symposium publication-title: Magnesium Res contributor: fullname: Cook – year: 2001 ident: 10.1016/j.neuroscience.2017.05.013_b0115 contributor: fullname: Paxinos – volume: 13 start-page: 332 year: 2013 ident: 10.1016/j.neuroscience.2017.05.013_b0145 article-title: Targeting TRPs in neurodegenerative disorders publication-title: Curr Top Med Chem doi: 10.2174/1568026611313030009 contributor: fullname: Takada – volume: 90 start-page: 107 year: 2015 ident: 10.1016/j.neuroscience.2017.05.013_b0080 article-title: Carvacrol attenuates traumatic neuronal injury through store-operated Ca2+ entry-independent regulation of intracellular Ca2+ homeostasis publication-title: Neurochem Int doi: 10.1016/j.neuint.2015.07.020 contributor: fullname: Li – volume: 6 start-page: 16321 year: 2015 ident: 10.1016/j.neuroscience.2017.05.013_b0015 article-title: Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion publication-title: Oncotarget doi: 10.18632/oncotarget.3872 contributor: fullname: Chen – volume: 58 start-page: 263 year: 2017 ident: 10.1016/j.neuroscience.2017.05.013_b0070 article-title: Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death and cognitive decline publication-title: Epilepsia doi: 10.1111/epi.13645 contributor: fullname: Khalil – volume: 230 start-page: 309 year: 2012 ident: 10.1016/j.neuroscience.2017.05.013_b0050 article-title: Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson’s disease publication-title: Behav Brain Res doi: 10.1016/j.bbr.2011.12.007 contributor: fullname: Glajch – volume: 152 start-page: 83 year: 2015 ident: 10.1016/j.neuroscience.2017.05.013_b0100 article-title: Effects of monoterpenes on ion channels of excitable cells publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2015.05.006 contributor: fullname: Oz – volume: 115 start-page: 863 year: 2003 ident: 10.1016/j.neuroscience.2017.05.013_b0005 article-title: A key role for TRPM7 channels in anoxic neuronal death publication-title: Cell doi: 10.1016/S0092-8674(03)01017-1 contributor: fullname: Aarts – volume: 530 start-page: 41 year: 2012 ident: 10.1016/j.neuroscience.2017.05.013_b0155 article-title: TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death publication-title: Neurosci Lett doi: 10.1016/j.neulet.2012.09.044 contributor: fullname: Verma – volume: 53 start-page: 595 year: 2016 ident: 10.1016/j.neuroscience.2017.05.013_b0150 article-title: TRPM7 regulates axonal outgrowth and maturation of primary hippocampal neurons publication-title: Mol Neurobiol doi: 10.1007/s12035-014-9032-y contributor: fullname: Turlova – volume: 8 start-page: e75532 year: 2013 ident: 10.1016/j.neuroscience.2017.05.013_b0060 article-title: Microglial cells are involved in the susceptibility of NADPHoxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration publication-title: PLoS One doi: 10.1371/journal.pone.0075532 contributor: fullname: Hernandes
SSID	ssj0000543
Score	2.4817114
Snippet	Highlights • TRPM7 increases after injections of 6-hydroxydopamine into the striatum. • Carvacrol reduces the loss of dopaminergic neurons induced by... •TRPM7 increases after injections of 6-hydroxydopamine into the striatum.•Carvacrol reduces the loss of dopaminergic neurons induced by... Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models of neurodegeneration, including ischemia, epilepsy and traumatic...
SourceID	proquest crossref pubmed elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	176
SubjectTerms	Animals carvacrol Disease Models, Animal dopamine Male Mice, Inbred C57BL Monoterpenes - pharmacology Neurology Neurons - drug effects Neurons - metabolism neuroprotection Neuroprotection - drug effects Neuroprotective Agents - pharmacology Parkinson Disease - drug therapy Substantia Nigra - drug effects TRP channels
Title	Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model
URI	https://www.clinicalkey.es/playcontent/1-s2.0-S0306452217303366 https://dx.doi.org/10.1016/j.neuroscience.2017.05.013 https://www.ncbi.nlm.nih.gov/pubmed/28526576 https://search.proquest.com/docview/1900832703
Volume	356
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1La9wwEBZNcumltE0f27RFhdLLYiNLtqU99LBsNmxLG0qTQOhF2LIMCa2zxJtD_31nJMs2CQsppRezDKwfM6NvRqN5EPK-VlwUeMJYJdxEKRjcqMxNHuGR2owxY5nCQuHViTw-V4fLdDnkqg60_yppoIGssXL2L6Td3xQI8BtkDleQOlzvJfcFDvsxmH2-dpl2tp26npVdQ4ZRaiNu-u0UGwasC4yYg-eNq93Nxhn7rMdDy8teCw4LnwbwJf4aB9rZT8BUF6VZ9bTv1g0UmC7iRU8Ddjl8-RF_i8dBh8RFM32Bso-EhWqYIfXIVWCxPMIO7d62eEBVUkTYZG-MuCIbY2Yi85H5TfwElzvI7oMMl_GozSd2OU26xqtisGd9luEJvhC-TwIwJkSe75A9DngEcLg3_7Q8_zyY7MynV4YPCN1pXSLgtidu82S27VScx3L6mDzqthp07nXkCXlgm6dkf94Um6tfv-kH6pJ_3anKPjnq1YYGtaG31IZeNBTUhjq1obfVhjq1eUbOjpani1XUjdiIDPjJm6iuElGpGodLikwZPsszXggJOG5rllrOZjg5JDVFyQpTMgvePSC-KhU3suIVF8_JbnPV2JeEpnmalFktS65UKkpezOoqNXVlZGlYZeoJEYFdeu07qeiQYnipx0zWyGTNMg1MnhAZOKtDrTBYN9t2S67ViW65ZvqOsCfkY__P7sbeS9SgUvd68rsgSA2Qi-doRWOBxRp8aNi4cLCVE_LCS7j_Iq5w3oTMX_3j0w_Iw2HdvSa7m-sb-4bstNXN2055_wBsvrCZ
link.rule.ids	315,782,786,27933,27934
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Carvacrol+promotes+neuroprotection+in+the+mouse+hemiparkinsonian+model&rft.jtitle=Neuroscience&rft.au=Dati%2C+L.M.&rft.au=Ulrich%2C+H.&rft.au=Real%2C+C.C.&rft.au=Feng%2C+Z.P.&rft.date=2017-07-25&rft.pub=Elsevier+Ltd&rft.issn=0306-4522&rft.eissn=1873-7544&rft.volume=356&rft.spage=176&rft.epage=181&rft_id=info:doi/10.1016%2Fj.neuroscience.2017.05.013&rft.externalDocID=S0306452217303366
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0306-4522&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0306-4522&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0306-4522&client=summon