Gene Therapy Enhances the Antiproliferative Effect of Radiation in Intimal Hyperplasia

Background. Although ionizing radiation (IR) has been demonstrated to attenuate vessel wall restenosis and intimal hyperplasia (IH), dose-related mural injury and atrophy are possible deleterious side effects. We tested the hypothesis that a radiosensitizing strategy may improve IR-induced inhibitio...

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Bibliographic Details
Published in:	The Journal of surgical research Vol. 89; no. 2; pp. 155 - 162
Main Authors:	Fortunato, John E., Mauceri, Helena J., Kocharyan, Hrachya, Song, Ruo H., Salloum, Rabih, Vosicky, James, Swedberg, Kirsten, Malik, Saira, Abusharif, Faris, Glagov, Seymour, Weichselbaum, Ralph R., Bassiouny, Hisham S.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-04-2000 Elsevier
Subjects:	5-fluorocytosine 5-fluorouracil Animals Apoptosis - drug effects Apoptosis - radiation effects Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Carotid Artery, Common - drug effects Carotid Artery, Common - pathology Carotid Artery, Common - physiopathology Cell Division - drug effects Cell Division - radiation effects Cytosine Deaminase Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Flucytosine - pharmacology Genetic Therapy Hemodynamics - drug effects Hemodynamics - radiation effects Hyperplasia - pathology intimal hyperplasia intimal/medial ionizing radiation Male Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Muscle, Smooth, Vascular - physiopathology Nucleoside Deaminases - genetics Pharmacology. Drug treatments Prodrugs - pharmacology proliferating cell nuclear antigen Rabbits right common carotid artery Tunica Intima - drug effects Tunica Intima - pathology Tunica Intima - radiation effects vascular smooth muscle cells Vascular wall 5-fluorouracil proliferating cell nuclear antigen right common carotid artery cytosine deaminase intimal hyperplasia vascular smooth muscle cells 5-fluorocytosine ionizing radiation intimal/medial Induction Hyperplasia Rabbit Cardiovascular disease Proliferation Lagomorpha Experimental study Radiotherapy Vascular disease Restenosis Vertebrata Mammalia Treatment Animal Blood vessel Intima Biological effect Inhibition Gene therapy
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