A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases

A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases

Chronic kidney disease (CKD) represents an increasing health burden. Evidence suggests the importance of miRNA in diagnosing CKD, yet the reports are inconsistent. This study aimed to determine novel miRNA biomarkers and potential therapeutic targets from hypothesis-free miRNA profiling studies in h...

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Published in:Non-coding RNA Vol. 10; no. 3; p. 30
Main Authors: Garmaa, Gantsetseg, Bunduc, Stefania, Kói, Tamás, Hegyi, Péter, Csupor, Dezső, Ganbat, Dariimaa, Dembrovszky, Fanni, Meznerics, Fanni Adél, Nasirzadeh, Ailar, Barbagallo, Cristina, Kökény, Gábor
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 03-05-2024
MDPI
Subjects:
Animal models
Apoptosis
Biomarkers
blood
chronic kidney disease
Chronic kidney failure
Development and progression
Diabetes
Diabetic nephropathy
Genes
Health aspects
Hypoxia
Kidney diseases
Lupus nephritis
Medical research
Medicine, Experimental
Meta-analysis
MicroRNA
MicroRNAs
miRNA
Statistical analysis
Systematic Review
Therapeutic targets
TOR protein
Urine
Hungary
meta-analysis
microRNA
chronic kidney disease
urine
blood
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Abstract Chronic kidney disease (CKD) represents an increasing health burden. Evidence suggests the importance of miRNA in diagnosing CKD, yet the reports are inconsistent. This study aimed to determine novel miRNA biomarkers and potential therapeutic targets from hypothesis-free miRNA profiling studies in human and murine CKDs. Comprehensive literature searches were conducted on five databases. Subgroup analyses of kidney diseases, sample types, disease stages, and species were conducted. A total of 38 human and 12 murine eligible studies were analyzed using Robust Rank Aggregation (RRA) and vote-counting analyses. Gene set enrichment analyses of miRNA signatures in each kidney disease were conducted using DIANA-miRPath v4.0 and MIENTURNET. As a result, top target genes, Gene Ontology terms, the interaction network between miRNA and target genes, and molecular pathways in each kidney disease were identified. According to vote-counting analysis, 145 miRNAs were dysregulated in human kidney diseases, and 32 were dysregulated in murine CKD models. By RRA, miR-26a-5p was significantly reduced in the kidney tissue of Lupus nephritis (LN), while miR-107 was decreased in LN patients' blood samples. In both species, epithelial-mesenchymal transition, Notch, mTOR signaling, apoptosis, G2/M checkpoint, and hypoxia were the most enriched pathways. These miRNA signatures and their target genes must be validated in large patient cohort studies.
AbstractList Chronic kidney disease (CKD) represents an increasing health burden. Evidence suggests the importance of miRNA in diagnosing CKD, yet the reports are inconsistent. This study aimed to determine novel miRNA biomarkers and potential therapeutic targets from hypothesis-free miRNA profiling studies in human and murine CKDs. Comprehensive literature searches were conducted on five databases. Subgroup analyses of kidney diseases, sample types, disease stages, and species were conducted. A total of 38 human and 12 murine eligible studies were analyzed using Robust Rank Aggregation (RRA) and vote-counting analyses. Gene set enrichment analyses of miRNA signatures in each kidney disease were conducted using DIANA-miRPath v4.0 and MIENTURNET. As a result, top target genes, Gene Ontology terms, the interaction network between miRNA and target genes, and molecular pathways in each kidney disease were identified. According to vote-counting analysis, 145 miRNAs were dysregulated in human kidney diseases, and 32 were dysregulated in murine CKD models. By RRA, miR-26a-5p was significantly reduced in the kidney tissue of Lupus nephritis (LN), while miR-107 was decreased in LN patients’ blood samples. In both species, epithelial-mesenchymal transition, Notch, mTOR signaling, apoptosis, G2/M checkpoint, and hypoxia were the most enriched pathways. These miRNA signatures and their target genes must be validated in large patient cohort studies.
Audience Academic
Author Barbagallo, Cristina
Kói, Tamás
Ganbat, Dariimaa
Bunduc, Stefania
Garmaa, Gantsetseg
Csupor, Dezső
Meznerics, Fanni Adél
Kökény, Gábor
Hegyi, Péter
Dembrovszky, Fanni
Nasirzadeh, Ailar
AuthorAffiliation 11 Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Mária utca 41, 1085 Budapest, Hungary
4 Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Dionisie Lupu Street 37, 020021 Bucharest, Romania
13 International Nephrology Research and Training Center, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary
8 Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary
9 Institute of Clinical Pharmacy, University of Szeged, Szikra utca 8, 6725 Szeged, Hungary
1 Institute of Translational Medicine, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary; gantsetseg.garmaa@gmail.com (G.G.); ailarr.nz@gmail.com (A.N.)
6 Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Baross út 22-24, 1085 Budapest, Hungary
5 Fundeni Clinical Institute, Fundeni Street 258, 022328 Bucharest, Romania
12 Section of Biology and Genetics “G. Sichel”, Department of Biomedical and Biotechn
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– name: 3 Department of Pathology, School of Medicine, Mongolian National University of Medical Sciences, Ulan-Bator 14210, Mongolia; dariimaa.ganbat21@gmail.com
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  surname: Kökény
  fullname: Kökény, Gábor
  organization: International Nephrology Research and Training Center, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38804362$$D View this record in MEDLINE/PubMed
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microRNA
chronic kidney disease
urine
blood
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Snippet Chronic kidney disease (CKD) represents an increasing health burden. Evidence suggests the importance of miRNA in diagnosing CKD, yet the reports are...
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SubjectTerms Animal models
Apoptosis
Biomarkers
blood
chronic kidney disease
Chronic kidney failure
Development and progression
Diabetes
Diabetic nephropathy
Genes
Health aspects
Hypoxia
Kidney diseases
Lupus nephritis
Medical research
Medicine, Experimental
Meta-analysis
MicroRNA
MicroRNAs
miRNA
Statistical analysis
Systematic Review
Therapeutic targets
TOR protein
Urine
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Title A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases
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