Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators

Human respiratory epithelium expresses inducible nitric oxide synthase (iNOS) continuously in vivo, however mechanisms responsible for maintenance of expression are not known. We show that IFNgamma is sufficient for induction of iNOS in primary human airway epithelial cells (HAEC) in vitro, and IL-4...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 100; no. 4; pp. 829 - 838
Main Authors:	Guo, F H, Uetani, K, Haque, S J, Williams, B R, Dweik, R A, Thunnissen, F B, Calhoun, W, Erzurum, S C
Format:	Journal Article
Language:	English
Published:	United States 15-08-1997
Subjects:	Adolescent Adult Antigens, CD - analysis Antigens, Differentiation, Myelomonocytic - analysis Bronchi - chemistry Bronchi - drug effects Bronchi - metabolism Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology CD3 Complex - analysis Cells, Cultured Culture Media, Conditioned - pharmacology Cycloheximide - pharmacology Epithelium - chemistry Female Gene Expression Regulation Humans Immunohistochemistry Interferon-gamma - analysis Interferon-gamma - pharmacology Interleukin-4 - analysis Interleukin-4 - pharmacology Keratins - analysis Male Middle Aged Nitric Oxide Synthase - metabolism omega-N-Methylarginine - pharmacology RNA, Messenger - metabolism Signal Transduction - drug effects Signal Transduction - physiology Time Factors Vimentin - analysis
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