Renal Transplantation in a Patient With Chronic Granulomatous Disease: Case Report

• Published in: Transplantation proceedings Vol. 47; no. 1; pp. 158 - 160
• Main Authors: Caliskan, B, Yazici, H, Gulluoglu, M, Caliskan, Y, Turkmen, A, Sever, M.S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2015
• Subjects: Adult; Anti-Infective Agents - adverse effects; Granulomatous Disease, Chronic - complications; Granulomatous Disease, Chronic - pathology; Granulomatous Disease, Chronic - surgery; Humans; Immunosuppressive Agents - adverse effects; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - pathology; Kidney Failure, Chronic - surgery; Kidney Transplantation; Liver Abscess - etiology; Liver Abscess - pathology; Liver Abscess - surgery; Male; Surgery
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2014.07.069

Abstract Chronic granulomatous disease (CGD) is a genetic disease caused by structural mutations in the enzyme NADPH oxidase that results in severe immunodeficiency. End-stage renal disease occurs in this patient population and is attributed to various factors, including infections, amyloidosis, and nephrotoxic anti-infective agents. In this report, we present our experience in transplantation for a patient with CGD complicated by isolated hepatic tuberculosis abscess. The course of the case demonstrates the absolute requirements for a multidisciplinary and compulsive approach before, during, and after transplantation. This case report also highlights the unexpectedly benign effects of immunosuppressive therapy in this patient population.