Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC

RNA interference (RNAi) molecules have tremendous potential for cancer therapy but are limited by insufficient potency after intravenous (IV) administration. We previously found that polymer complexes (polyplexes) formed between 3'-cholesterol-modified siRNA (Chol-siRNA) or DsiRNA (Chol-DsiRNA)...

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Bibliographic Details
Published in:	Non-coding RNA Vol. 8; no. 1; p. 8
Main Authors:	Ye, Zhen, Abdelmoaty, Mai Mohamed, Curran, Stephen M, Dyavar, Shetty Ravi, Kumar, Devendra, Alnouti, Yazen, Coulter, Don W, Podany, Anthony T, Singh, Rakesh K, Vetro, Joseph A
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 13-01-2022 MDPI
Subjects:	Animal models Breast cancer Cancer therapies Chol-DsiRNA polymer micelles Cholesterol Dosage drug delivery DsiRNA delivery Intravenous administration MicroRNAs mRNA Polyethylene glycol Polymers RNA-mediated interference RNAi RNAi delivery siRNA siRNA delivery Solid tumors Stat3 protein Tumors RNAi Chol-DsiRNA polymer micelles Chol-siRNA polymer micelles siRNA delivery drug delivery DsiRNA delivery RNAi delivery
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