Transcriptional Regulation of a BMP‐6 Promoter by Estrogen Receptor α

The effects of 17β‐estradiol (E2) and ICI 182,780 (ICI) on activity of a BMP‐6 promoter were compared in osteoblast‐like and breast cancer cells transiently transfected with ERα. E2 but not ICI stimulated BMP‐6 reporter activity in breast cancer cells, whereas the opposite was observed in osteoblast...

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Bibliographic Details
Published in:	Journal of bone and mineral research Vol. 19; no. 3; pp. 447 - 454
Main Authors:	Ong, Delia B, Colley, Shane M, Norman, Michael R, Kitazawa, Sohei, Tobias, Jonathan H
Format:	Journal Article
Language:	English
Published:	Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01-03-2004 American Society for Bone and Mineral Research
Subjects:	Animals antiestrogens Biological and medical sciences Bone Morphogenetic Protein 6 Bone Morphogenetic Proteins - biosynthesis Bone Morphogenetic Proteins - genetics Cell Line, Tumor Estradiol - analogs & derivatives Estradiol - physiology estrogen receptor Estrogen Receptor alpha - physiology Female Fundamental and applied biological sciences. Psychology Humans osteoblasts Osteogenesis Promoter Regions, Genetic Rats Signal Transduction Skeleton and joints Transcription, Genetic Up-Regulation Vertebrates: osteoarticular system, musculoskeletal system estrogen receptor Antiestrogen Estrogen antiestrogens Ovarian hormone Promoter Osteoarticular system Estrogen receptor α Vertebrata Mammalia Bone morphogenetic protein Osteoblast Bone osteoblasts Sex steroid hormone Biological receptor bone morphogenetic protein 6
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