Association between NOGGIN and SPRY2 polymorphisms and nonsyndromic cleft lip with or without cleft palate

Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital malformation with a worldwide prevalence rate of 0.4–2.0% among live births, depending on race and ethnic background. Single‐nucleotide polymorphisms (SNPs) of genes may contribute to NSCLP risk, although the risk fac...

Full description

Saved in:

Bibliographic Details
Published in:	American journal of medical genetics. Part A Vol. 167A; no. 1; pp. 137 - 141
Main Authors:	Song, Tao, Shi, Jinna, Guo, Qiang, Lv, Kewen, Jiao, Xiaohui, Hu, Tenglong, Sun, Xiangyu, Fu, Songbin
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-01-2015 Wiley Subscription Services, Inc
Subjects:	Adolescent Adult Alleles Carrier Proteins - genetics Case-Control Studies Child Child, Preschool Cleft Lip - complications Cleft Lip - genetics Cleft Palate - complications Cleft Palate - genetics Female Genetic Association Studies Genetic Predisposition to Disease Haplotypes Humans Infant Intracellular Signaling Peptides and Proteins - genetics Male Membrane Proteins - genetics NOG Nonsyndromic cleft lip with or without cleft palate (NSCLP) Odds Ratio Polymorphism, Single Nucleotide - genetics SNPs SPRY2 Young Adult SNPs SPRY2 NOG Nonsyndromic cleft lip with or without cleft palate (NSCLP)
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital malformation with a worldwide prevalence rate of 0.4–2.0% among live births, depending on race and ethnic background. Single‐nucleotide polymorphisms (SNPs) of genes may contribute to NSCLP risk, although the risk factors and pathogenesis of NSCLP remain unknown. The objective of this study was to investigate association of SNPs of noggin (NOG) and sprouty homolog 2 (SPRY2) with NSCLP risk. A total of 188 NSCLP patients and 228 healthy controls from northern China were recruited for genotyping of these SNPs using the SNaP shot method. The frequency of the NOG rs227731 genotype was significantly lower among NSCLP cases than among controls. Logistic regression analysis showed rs227731 CC genotype was associated with decreased NSCLP susceptibility (OR = 0.31, 95% CI = 0.12–0.80) compared to the AA homozygote. However, no association between SPRY2, SNPs, and NSCLP risk were observed in this cohort of patients. In conclusion, NOG rs227731 genotype was associated with decreased NSCLP risk in a Northern Chinese population. © 2014 Wiley Periodicals, Inc.
AbstractList	Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital malformation with a worldwide prevalence rate of 0.4–2.0% among live births, depending on race and ethnic background. Single‐nucleotide polymorphisms (SNPs) of genes may contribute to NSCLP risk, although the risk factors and pathogenesis of NSCLP remain unknown. The objective of this study was to investigate association of SNPs of noggin (NOG) and sprouty homolog 2 (SPRY2) with NSCLP risk. A total of 188 NSCLP patients and 228 healthy controls from northern China were recruited for genotyping of these SNPs using the SNaP shot method. The frequency of the NOG rs227731 genotype was significantly lower among NSCLP cases than among controls. Logistic regression analysis showed rs227731 CC genotype was associated with decreased NSCLP susceptibility (OR = 0.31, 95% CI = 0.12–0.80) compared to the AA homozygote. However, no association between SPRY2, SNPs, and NSCLP risk were observed in this cohort of patients. In conclusion, NOG rs227731 genotype was associated with decreased NSCLP risk in a Northern Chinese population. © 2014 Wiley Periodicals, Inc. Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital malformation with a worldwide prevalence rate of 0.4-2.0% among live births, depending on race and ethnic background. Single-nucleotide polymorphisms (SNPs) of genes may contribute to NSCLP risk, although the risk factors and pathogenesis of NSCLP remain unknown. The objective of this study was to investigate association of SNPs of noggin (NOG) and sprouty homolog 2 (SPRY2) with NSCLP risk. A total of 188 NSCLP patients and 228 healthy controls from northern China were recruited for genotyping of these SNPs using the SNaP shot method. The frequency of the NOG rs227731 genotype was significantly lower among NSCLP cases than among controls. Logistic regression analysis showed rs227731 CC genotype was associated with decreased NSCLP susceptibility (OR=0.31, 95% CI=0.12-0.80) compared to the AA homozygote. However, no association between SPRY2, SNPs, and NSCLP risk were observed in this cohort of patients. In conclusion, NOG rs227731 genotype was associated with decreased NSCLP risk in a Northern Chinese population. copyright 2014 Wiley Periodicals, Inc. Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital malformation with a worldwide prevalence rate of 0.4-2.0% among live births, depending on race and ethnic background. Single-nucleotide polymorphisms (SNPs) of genes may contribute to NSCLP risk, although the risk factors and pathogenesis of NSCLP remain unknown. The objective of this study was to investigate association of SNPs of noggin (NOG) and sprouty homolog 2 (SPRY2) with NSCLP risk. A total of 188 NSCLP patients and 228 healthy controls from northern China were recruited for genotyping of these SNPs using the SNaP shot method. The frequency of the NOG rs227731 genotype was significantly lower among NSCLP cases than among controls. Logistic regression analysis showed rs227731 CC genotype was associated with decreased NSCLP susceptibility (OR = 0.31, 95% CI = 0.12-0.80) compared to the AA homozygote. However, no association between SPRY2, SNPs, and NSCLP risk were observed in this cohort of patients. In conclusion, NOG rs227731 genotype was associated with decreased NSCLP risk in a Northern Chinese population.
Author	Fu, Songbin Lv, Kewen Shi, Jinna Hu, Tenglong Sun, Xiangyu Guo, Qiang Song, Tao Jiao, Xiaohui
Author_xml	– sequence: 1 givenname: Tao surname: Song fullname: Song, Tao organization: Department of Stomatology, The First Affiliated Hospital, Harbin Medical University, Heilongjiang, Harbin, China – sequence: 2 givenname: Jinna surname: Shi fullname: Shi, Jinna organization: Department of Stomatology, The First Affiliated Hospital, Harbin Medical University, Heilongjiang, Harbin, China – sequence: 3 givenname: Qiang surname: Guo fullname: Guo, Qiang email: Correspondence to:Qiang Guo, Scientific Research Management Office, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, China., omfs@163.com organization: Scientific Research Management Office, The First Affiliated Hospital, Harbin Medical University, Heilongjiang, Harbin, China – sequence: 4 givenname: Kewen surname: Lv fullname: Lv, Kewen organization: Department of Stomatology, The First Affiliated Hospital, Harbin Medical University, Heilongjiang, Harbin, China – sequence: 5 givenname: Xiaohui surname: Jiao fullname: Jiao, Xiaohui organization: Department of Stomatology, The First Affiliated Hospital, Harbin Medical University, Heilongjiang, Harbin, China – sequence: 6 givenname: Tenglong surname: Hu fullname: Hu, Tenglong organization: Department of Stomatology, The First Affiliated Hospital, Harbin Medical University, Heilongjiang, Harbin, China – sequence: 7 givenname: Xiangyu surname: Sun fullname: Sun, Xiangyu organization: Department of Stomatology, The First Affiliated Hospital, Harbin Medical University, Heilongjiang, Harbin, China – sequence: 8 givenname: Songbin surname: Fu fullname: Fu, Songbin organization: Laboratory of Medical Genetics, Harbin Medical University, Heilongjiang, Harbin, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25339627$$D View this record in MEDLINE/PubMed
BookMark	eNqNkUuP0zAUhS00iHnAjjWyxIYFLX4nXlajITOodArDQ6ws13EYlyQOdqJO_z1O2-mCBWJ1r-zvHl-fcw5OWt9aAF5iNMUIkXd63fyc6ikVOSJPwBnmnExYTunJsSf8FJzHuEaIIp6JZ-CUcEqlINkZWM9i9Mbp3vkWrmy_sbaFi9uiuFlA3Zbwbvn5B4Gdr7eND929i03cnacl4rYtg2-cgaa2VQ9r18GN6--hD7vqh_5w0-la9_Y5eFrpOtoXh3oBvr6_-nJ5PZnfFjeXs_nEMJr2pZxWVGSGS2krUjKGtc1WLLNIloYTIWSJTV6haoVZLigzmmYcMyNlglJLL8CbvW4X_O_Bxl41Lhpb17q1fogKC5ahZB2S_4FSKbNkZp7Q13-haz-ENn1kpPI8l5KMb7_dUyb4GIOtVBdco8NWYaTGuNQYl9JqF1fCXx1Eh1VjyyP8mE8C2B7YuNpu_ymmZh8-FrNH3cl-zMXePhzHdPilxOiR-r4olJgv7-Snb0uF6B_vbrCe
CitedBy_id	crossref_primary_10_1002_bdra_23391 crossref_primary_10_1007_s10006_022_01052_3 crossref_primary_10_1007_s12041_019_1090_5 crossref_primary_10_1055_s_0041_1726162 crossref_primary_10_1088_1742_6596_1943_1_012090 crossref_primary_10_5812_pmco_115500 crossref_primary_10_1007_s00439_015_1606_x crossref_primary_10_3390_ijerph16040557 crossref_primary_10_1002_bdra_23612
Cites_doi	10.1056/NEJMoa032909 10.1038/ng.506 10.1016/j.mod.2007.06.007 10.1016/S0140-6736(09)60695-4 10.1086/510518 10.1038/74155 10.1038/nrg2933 10.1371/journal.pgen.0010064 10.1111/j.1601-0825.2010.01741.x 10.1126/science.1128406 10.1007/s00441-004-0869-7 10.1002/dvdy.21195 10.1242/dev.01676 10.1038/ng740 10.1016/j.ajhg.2009.02.002 10.1038/ng.333 10.1038/35038565 10.1086/344779 10.1242/dev.129.19.4647 10.1016/j.tig.2007.09.002 10.2174/138161206776389868 10.1016/j.ydbio.2010.08.014 10.1016/j.ajhg.2009.10.015
ContentType	Journal Article
Copyright	2014 Wiley Periodicals, Inc.
Copyright_xml	– notice: 2014 Wiley Periodicals, Inc.
DBID	BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7TK 8FD FR3 K9. P64 RC3 7X8
DOI	10.1002/ajmg.a.36802
DatabaseName	Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Technology Research Database ProQuest Health & Medical Complete (Alumni) Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitleList	Genetics Abstracts MEDLINE Genetics Abstracts
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Biology
EISSN	1552-4833
EndPage	141
ExternalDocumentID	3533512491 10_1002_ajmg_a_36802 25339627 AJMGA36802 ark_67375_WNG_6LPS9QVP_0
Genre	article Research Support, Non-U.S. Gov't Journal Article
GrantInformation_xml	– fundername: China Postdoctoral Science Foundation funderid: 20110491104 – fundername: Scientific Research Fund funderid: 11551183 – fundername: Scientific Research Fund funderid: 2009B06 – fundername: Youth Scientific Research Fund funderid: QC2011C068
GroupedDBID	--- .55 .GA .Y3 05W 10A 1L6 1OC 23M 31~ 33P 3O- 4.4 50Y 51W 51X 52M 52N 52O 52P 52S 52T 52W 52X 53G 5GY 5VS 66C 6P2 702 7PT 8-1 8-4 8-5 8UM 930 A03 AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFO ACGFS ACPOU ACPRK ACSCC ACXBN ACXQS ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFZJQ AHBTC AITYG AIURR AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AZBYB AZFZN BDRZF BFHJK BRXPI BSCLL BY8 C45 CO8 CS3 D-F DCZOG DPXWK DR2 DRFUL DRSTM EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE G-S GNP GODZA HBH HF~ HGLYW HHY HHZ HVGLF IX1 JPC KD1 KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LYRES MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM OIG OVD P2W P4D QB0 QRW ROL RWI RX1 RYL SUPJJ SV3 TEORI UB1 V2E WIH WIK WJL WQJ WRC X7M XG1 XV2 CGR CUY CVF ECM EIF NPM AAMNL AAYXX CITATION 7QP 7TK 8FD FR3 K9. P64 RC3 7X8
ID	FETCH-LOGICAL-c4352-353f367c599ef2d441ae7b47e09dc52669d1c8f0fb148634ca37514c99b473753
IEDL.DBID	33P
ISSN	1552-4825
IngestDate	Fri Aug 16 05:50:26 EDT 2024 Fri Aug 16 22:30:29 EDT 2024 Tue Nov 19 05:46:54 EST 2024 Thu Nov 21 21:30:21 EST 2024 Tue Aug 27 13:50:25 EDT 2024 Sat Aug 24 00:49:12 EDT 2024 Wed Oct 30 09:50:24 EDT 2024
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	SNPs SPRY2 NOG Nonsyndromic cleft lip with or without cleft palate (NSCLP)
Language	English
License	2014 Wiley Periodicals, Inc.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c4352-353f367c599ef2d441ae7b47e09dc52669d1c8f0fb148634ca37514c99b473753
Notes	ark:/67375/WNG-6LPS9QVP-0 China Postdoctoral Science Foundation - No. 20110491104 Youth Scientific Research Fund - No. QC2011C068 ArticleID:AJMGA36802 istex:566CC2CCB2107EE978E7235523C0D88ED940A048 Scientific Research Fund - No. 11551183 Scientific Research Fund - No. 2009B06 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	25339627
PQID	1638889925
PQPubID	2028748
PageCount	5
ParticipantIDs	proquest_miscellaneous_1647010009 proquest_miscellaneous_1639978338 proquest_journals_1638889925 crossref_primary_10_1002_ajmg_a_36802 pubmed_primary_25339627 wiley_primary_10_1002_ajmg_a_36802_AJMGA36802 istex_primary_ark_67375_WNG_6LPS9QVP_0
PublicationCentury	2000
PublicationDate	2015-01 January 2015 2015-Jan 2015-01-00 20150101
PublicationDateYYYYMMDD	2015-01-01
PublicationDate_xml	– month: 01 year: 2015 text: 2015-01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: Hoboken
PublicationTitle	American journal of medical genetics. Part A
PublicationTitleAlternate	Am. J. Med. Genet
PublicationYear	2015
Publisher	Blackwell Publishing Ltd Wiley Subscription Services, Inc
Publisher_xml	– name: Blackwell Publishing Ltd – name: Wiley Subscription Services, Inc
References	Goodnough LH, Brugmann SA, Hu D, Helms JA. 2007. Stage-dependent craniofacial defects resulting from Sprouty2 overexpression. Dev Dyn 236:1918-1928. Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC. 2009. Cleft lip and palate. Lancet 374:1773-1785. Jin L, Su B. 2000. Natives or immigrants: Modern human origin in east Asia. Nat Rev Genet 1:126-133. He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y. 2010. Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol 347:109-121. Suzuki S, Marazita ML, Cooper ME, Miwa N, Hing A, Jugessur A, Natsume N, Shimozato K, Ohbayashi N, Suzuki Y, Niimi T, Minami K, Yamamoto M, Altannamar TJ, Erkhembaatar T, Furukawa H, Daack-Hirsch S, L'Heureux J, Brandon CA, Weinberg SM, Neiswanger K, Deleyiannis FW, de Salamanca JE, Vieira AR, Lidral AC, Martin JF, Murray JC. 2009. Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip. Am J Hum Genet 84:406-411. Zucchero TM, Cooper ME, Maher BS, Daack-Hirsch S, Nepomuceno B, Ribeiro L, Caprau D, Christensen K, Suzuki Y, Machida J, Natsume N, Yoshiura K, Vieira AR, Orioli IM, Castilla EE, Moreno L, Arcos-Burgos M, Lidral AC, Field LL, Liu YE, Ray A, Goldstein TH, Schultz RE, Shi M, Johnson MK, Kondo S, Schutte BC, Marazita ML, Murray JC. 2004. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med 351:769-780. Xu S, Yin X, Li S, Jin W, Lou H, Yang L, Gong X, Wang H, Shen Y, Pan X, He Y, Yang Y, Wang Y, Fu W, An Y, Wang J, Tan J, Qian J, Chen X, Zhang X, Sun Y, Wu B, Jin L. 2009. Genomic dissection of population substructure of Han Chinese and its implication in association studies. Am J Hum Genet 85:762-774. Vieira AR, Avila JR, Daack-Hirsch S, Dragan E, Felix TM, Rahimov F, Harrington J, Schultz RR, Watanabe Y, Johnson M, Fang J, O'Brien SE, Orioli IM, Castilla EE, Fitzpatrick DR, Jiang R, Marazita ML, Murray JC. 2005. Medical sequencing of candidate genes for nonsyndromic cleft lip and palate. PLoS Genet 1:64. Schliekelman P, Slatkin M. 2002. Multiplex relative risk and estimation of the number of loci underlying an inherited disease. Am J Hum Genet 71:1369-1385. Alkuraya FS, Saadi I, Lund JJ, Turbe-Doan A, Morton CC, Maas RL. 2006. SUMO1 haploinsufficiency leads to cleft lip and palate. Science 313:1751. Liu W, Sun X, Braut A, Mishina Y, Behringer RR, Mina M, Martin JF. 2005. Distinct functions for Bmp signaling in lip and palate fusion in mice. Development 132:1453-1461. Mangold E, Ludwig KU, Birnbaum S, Baluardo C, Ferrian M, Herms S, Reutter H, de Assis NA, Chawa TA, Mattheisen M, Steffens M, Barth S, Kluck N, Paul A, Becker J, Lauster C, Schmidt G, Braumann B, Scheer M, Reich RH, Hemprich A, Potzsch S, Blaumeiser B, Moebus S, Krawczak M, Schreiber S, Meitinger T, Wichmann HE, Steegers-Theunissen RP, Kramer FJ, Cichon S, Propping P, Wienker TF, Knapp M, Rubini M, Mossey PA, Hoffmann P, Nothen MM. 2010. Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. Nat Genet 42:24-26. Welsh IC, Hagge-Greenberg A, O'Brien TP. 2007. A dosage-dependent role for Spry2 in growth and patterning during palate development. Mech Dev 124:746-761. Webster WS, Howe AM, Abela D, Oakes DJ. 2006. The relationship between cleft lip, maxillary hypoplasia, hypoxia and phenytoin. Curr Pharm Des 12:1431-1448. Ashique AM, Fu K, Richman JM. 2002. Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusion. Development 129:4647-4660. Dixon MJ, Marazita ML, Beaty TH, Murray JC. 2011. Cleft lip and palate: Understanding genetic and environmental influences. Nat Rev Genet 12:167-178. Pauws E, Stanier P. 2007. FGF signalling and SUMO modification: New players in the aetiology of cleft lip and/or palate. Trends Genet 23:631-640. Birnbaum S, Ludwig KU, Reutter H, Herms S, Steffens M, Rubini M, Baluardo C, Ferrian M, Almeida de Assis N, Alblas MA, Barth S, Freudenberg J, Lauster C, Schmidt G, Scheer M, Braumann B, Berge SJ, Reich RH, Schiefke F, Hemprich A, Potzsch S, Steegers-Theunissen RP, Potzsch B, Moebus S, Horsthemke B, Kramer FJ, Wienker TF, Mossey PA, Propping P, Cichon S, Hoffmann P, Knapp M, Nothen MM, Mangold E. 2009. Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet 41:473-477. Pan Y, Ma J, Zhang W, Wang Y, Zhang H, Wang M, Zhang Z, Wang L. 2011. Replication of two novel susceptibility loci for non-syndromic orofacial clefts in a Chinese population. Oral Dis 17:304-308. Schroder HC, Perovic-Ottstadt S, Wiens M, Batel R, Muller IM, Muller WE. 2004. Differentiation capacity of epithelial cells in the sponge Suberites domuncula. Cell Tissue Res 316:271-280. Shi M, Christensen K, Weinberg CR, Romitti P, Bathum L, Lozada A, Morris RW, Lovett M, Murray JC. 2007. Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. Am J Hum Genet 80:76-90. Sozen MA, Suzuki K, Tolarova MM, Bustos T, Fernandez Iglesias JE, Spritz RA. 2001. Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela. Nat Genet 29:141-142. van den Boogaard MJ, Dorland M, Beemer FA, van Amstel HK. 2000. MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. Nat Genet 24:342-343. 2007; 236 2010; 42 2007; 124 2004; 351 2009; 41 2009; 85 2009; 84 2005; 132 2006; 12 2010; 347 2000; 24 2009; 374 2002; 129 2007; 80 2005; 1 2011; 12 2000; 1 2002; 71 2001; 29 2011; 17 2006; 313 2004; 316 2007; 23 e_1_2_6_21_1 e_1_2_6_10_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_19_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_11_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_12_1 e_1_2_6_22_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_16_1
References_xml	– volume: 71 start-page: 1369 year: 2002 end-page: 1385 article-title: Multiplex relative risk and estimation of the number of loci underlying an inherited disease publication-title: Am J Hum Genet – volume: 351 start-page: 769 year: 2004 end-page: 780 article-title: Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate publication-title: N Engl J Med – volume: 24 start-page: 342 year: 2000 end-page: 343 article-title: MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans publication-title: Nat Genet – volume: 347 start-page: 109 year: 2010 end-page: 121 article-title: Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis publication-title: Dev Biol – volume: 316 start-page: 271 year: 2004 end-page: 280 article-title: Differentiation capacity of epithelial cells in the sponge Suberites domuncula publication-title: Cell Tissue Res – volume: 374 start-page: 1773 year: 2009 end-page: 1785 article-title: Cleft lip and palate publication-title: Lancet – volume: 17 start-page: 304 year: 2011 end-page: 308 article-title: Replication of two novel susceptibility loci for non‐syndromic orofacial clefts in a Chinese population publication-title: Oral Dis – volume: 124 start-page: 746 year: 2007 end-page: 761 article-title: A dosage‐dependent role for Spry2 in growth and patterning during palate development publication-title: Mech Dev – volume: 313 start-page: 1751 year: 2006 article-title: SUMO1 haploinsufficiency leads to cleft lip and palate publication-title: Science – volume: 29 start-page: 141 year: 2001 end-page: 142 article-title: Mutation of PVRL1 is associated with sporadic, non‐syndromic cleft lip/palate in northern Venezuela publication-title: Nat Genet – volume: 12 start-page: 1431 year: 2006 end-page: 1448 article-title: The relationship between cleft lip, maxillary hypoplasia, hypoxia and phenytoin publication-title: Curr Pharm Des – volume: 85 start-page: 762 year: 2009 end-page: 774 article-title: Genomic dissection of population substructure of Han Chinese and its implication in association studies publication-title: Am J Hum Genet – volume: 41 start-page: 473 year: 2009 end-page: 477 article-title: Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 publication-title: Nat Genet – volume: 23 start-page: 631 year: 2007 end-page: 640 article-title: FGF signalling and SUMO modification: New players in the aetiology of cleft lip and/or palate publication-title: Trends Genet – volume: 1 start-page: 64 year: 2005 article-title: Medical sequencing of candidate genes for nonsyndromic cleft lip and palate publication-title: PLoS Genet – volume: 1 start-page: 126 year: 2000 end-page: 133 article-title: Natives or immigrants: Modern human origin in east Asia publication-title: Nat Rev Genet – volume: 132 start-page: 1453 year: 2005 end-page: 1461 article-title: Distinct functions for Bmp signaling in lip and palate fusion in mice publication-title: Development – volume: 236 start-page: 1918 year: 2007 end-page: 1928 article-title: Stage‐dependent craniofacial defects resulting from Sprouty2 overexpression publication-title: Dev Dyn – volume: 84 start-page: 406 year: 2009 end-page: 411 article-title: Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip publication-title: Am J Hum Genet – volume: 12 start-page: 167 year: 2011 end-page: 178 article-title: Cleft lip and palate: Understanding genetic and environmental influences publication-title: Nat Rev Genet – volume: 42 start-page: 24 year: 2010 end-page: 26 article-title: Genome‐wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate publication-title: Nat Genet – volume: 80 start-page: 76 year: 2007 end-page: 90 article-title: Orofacial cleft risk is increased with maternal smoking and specific detoxification‐gene variants publication-title: Am J Hum Genet – volume: 129 start-page: 4647 year: 2002 end-page: 4660 article-title: Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusion publication-title: Development – ident: e_1_2_6_24_1 doi: 10.1056/NEJMoa032909 – ident: e_1_2_6_10_1 doi: 10.1038/ng.506 – ident: e_1_2_6_22_1 doi: 10.1016/j.mod.2007.06.007 – ident: e_1_2_6_11_1 doi: 10.1016/S0140-6736(09)60695-4 – ident: e_1_2_6_16_1 doi: 10.1086/510518 – ident: e_1_2_6_19_1 doi: 10.1038/74155 – ident: e_1_2_6_5_1 doi: 10.1038/nrg2933 – ident: e_1_2_6_20_1 doi: 10.1371/journal.pgen.0010064 – ident: e_1_2_6_12_1 doi: 10.1111/j.1601-0825.2010.01741.x – ident: e_1_2_6_2_1 doi: 10.1126/science.1128406 – ident: e_1_2_6_15_1 doi: 10.1007/s00441-004-0869-7 – ident: e_1_2_6_6_1 doi: 10.1002/dvdy.21195 – ident: e_1_2_6_9_1 doi: 10.1242/dev.01676 – ident: e_1_2_6_17_1 doi: 10.1038/ng740 – ident: e_1_2_6_18_1 doi: 10.1016/j.ajhg.2009.02.002 – ident: e_1_2_6_4_1 doi: 10.1038/ng.333 – ident: e_1_2_6_8_1 doi: 10.1038/35038565 – ident: e_1_2_6_14_1 doi: 10.1086/344779 – ident: e_1_2_6_3_1 doi: 10.1242/dev.129.19.4647 – ident: e_1_2_6_13_1 doi: 10.1016/j.tig.2007.09.002 – ident: e_1_2_6_21_1 doi: 10.2174/138161206776389868 – ident: e_1_2_6_7_1 doi: 10.1016/j.ydbio.2010.08.014 – ident: e_1_2_6_23_1 doi: 10.1016/j.ajhg.2009.10.015
SSID	ssj0030576
Score	2.1657076
Snippet	Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital malformation with a worldwide prevalence rate of 0.4–2.0% among live births,... Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital malformation with a worldwide prevalence rate of 0.4-2.0% among live births,...
SourceID	proquest crossref pubmed wiley istex
SourceType	Aggregation Database Index Database Publisher
StartPage	137
SubjectTerms	Adolescent Adult Alleles Carrier Proteins - genetics Case-Control Studies Child Child, Preschool Cleft Lip - complications Cleft Lip - genetics Cleft Palate - complications Cleft Palate - genetics Female Genetic Association Studies Genetic Predisposition to Disease Haplotypes Humans Infant Intracellular Signaling Peptides and Proteins - genetics Male Membrane Proteins - genetics NOG Nonsyndromic cleft lip with or without cleft palate (NSCLP) Odds Ratio Polymorphism, Single Nucleotide - genetics SNPs SPRY2 Young Adult
Title	Association between NOGGIN and SPRY2 polymorphisms and nonsyndromic cleft lip with or without cleft palate
URI	https://api.istex.fr/ark:/67375/WNG-6LPS9QVP-0/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fajmg.a.36802 https://www.ncbi.nlm.nih.gov/pubmed/25339627 https://www.proquest.com/docview/1638889925 https://search.proquest.com/docview/1639978338 https://search.proquest.com/docview/1647010009
Volume	167A
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3rb9MwED-NTSC-sDEeC3vISMC3bGmcxPGXSdUeHYiVQnl-shw_po62qZpWYv_9zk7abRKahPgUKz4rju_O9zs_7gDeyJaOLIsK1LRIh4lWUcgRFoUUrWHeMlaZzN13Puuz7s_8-MSFyTlc3IWp40MsF9ycZvj52im4LKqDm6Ch8nJ0sS_3aZb7WJLoKPgbHLS3mIhRkn1uORdkLEzQE2rOvWPzg9uN71ikNTe4f_4GN--iV29-Ttf_t-Mb8KQBnqRdS8pTWDHjTXhYp6K82oRH580m-zO4vMUy0pzjIt1Pnc77LpFjTfq9L79iMimHV6MSuTSoRpV_P0YBruMfDBTBb9gZGQ4mxK30knLqn-V81tRM5BBR7nP4dnry9egsbFIyhApxlTv3Ty3NmEo5NzbWiKWkYUXCTMS1StHYc91SuY1sgW5WRhMlKUNIpjhHIizSF7CKvTFbQAqtEZu0uEUImcSFLqQ1KilSFCqWSi4DeLtgi5jUkTdEHWM5Fm4IhRR-CAN453m2JJLT3-60GkvFj25HZB97ff75e09EAewsmCoaRa2Eg6M5-pxxGsDrZTWqmNs3kWNTzj0NdytkNL-PJmGR2yvhAbysBWbZoRghtctxFEDo5eLe3xHtD-edti---kf6bXiMcC6tF4h2YHU2nZtdeFDp-Z5XjGtPMg6K
link.rule.ids	315,782,786,1408,27933,27934,46064,46488
linkProvider	Wiley-Blackwell
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3rb9MwED_BJh5feIxXYICRgG_Z0jiJ40-ogq0dtKHQjccny_EDdbRN1YfE_nvOTlo2CU1CfIoVnxXHd2f_fD7fAbyULR1ZFpWoaZEOE62ikCMsCimuhnnLWGUyd9-5O2TFt_zdgQuT82Z9F6aOD7ExuDnN8PO1U3BnkN7_EzVUnk5-7Mk9muUumOR2kqEsujscdLCeilGWfXY5F2YsTHAv1Hi-Y_v9860vrEnbbnh__Q1wXsSvfgE6vP3fXb8DtxrsSdq1sNyFK2a6A9fqbJRnO3C935yz34PTc1wjjSsXKT52OkcFkVNNhoPP32Myq8ZnkwoZNVpMFv79FGW4DoEwUgS_YZdkPJoRZ-wl1dw_q9WyqZnJMQLd-3ByeHD8ths2WRlChdDKuf5TSzOmUs6NjTXCKWlYmTATca1SXO-5bqncRrbEnVZGEyUpQ1SmOEciLNIHsIW9MY-AlFojPGlxiygyiUtdSmtUUqYoVyyVXAbwas0XMauDb4g6zHIs3BAKKfwQBvDaM21DJOc_ncMaS8XXoiOy3mDIP30ZiCiA3TVXRaOrC-EQaY7bzjgN4MWmGrXMHZ3IqalWnoY7IxnNL6NJWOSOS3gAD2uJ2XQoRlTt0hwFEHrBuPR3RPt9v9P2xcf_SP8cbnSP-z3ROyo-PIGbiO7S2l60C1vL-co8hasLvXrmteQ3Xe0Ssg
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwEB5BKypeSilXSgtGAt7SZuNcfkFa0e620IbAUo4ny_GBtuxuoj0k-u8ZO9mllVAlxFOseKw4nhn789j-DPBSdFRg0qBETwuUHykZ-AxhkU9xNMw62kid2PPOx4M0_5YdHlmanDfLszANP8Qq4GY9w_XX1sFrZQ7-kIaKi_GPfbFPk8xySa5HiMQtdz6lxbInRlN2l8tZljE_wqlQu_Edyx9cLX1tSFq3rfvrb3jzOnx140_v3v_WfAs2W-RJuo2p3IdberINd5q7KC-3YeOsXWV_ABdXdEbajVwk_9Dvn-RETBQZFJ--h6SuRpfjCtU0nI1n7v0ELbghQBhKgt8wczIa1sSGekk1dc9qMW9zajFCmPsQzntHn98e--2dDL5EYGU3_lNDk1TGjGkTKgRTQqdllOqAKRnjaM9UR2YmMCXOsxIaSUFTxGSSMRTCJH0Ea1gb_QRIqRSCkw4ziCGjsFSlMFpGZYxWlcaCCQ9eLdXC64Z6gzckyyG3TcgFd03owWuns5WQmP6029XSmH_N-zw5LQbs45eCBx7sLpXKW0-dcYtHM5x0hrEHL1bZ6GN24URMdLVwMsyGyGh2k0yUBnaxhHnwuDGYVYVCxNT2kiMPfGcXN_4O774763ddcucf5Z_DRnHY46cn-funcBehXdwEi3ZhbT5d6D24PVOLZ85HfgP0jxFY
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+between+NOGGIN+and+SPRY2+polymorphisms+and+nonsyndromic+cleft+lip+with+or+without+cleft+palate&rft.jtitle=American+journal+of+medical+genetics.+Part+A&rft.au=Song%2C+Tao&rft.au=Shi%2C+Jinna&rft.au=Guo%2C+Qiang&rft.au=Lv%2C+Kewen&rft.date=2015-01-01&rft.issn=1552-4825&rft.eissn=1552-4833&rft.volume=167&rft.issue=1&rft.spage=137&rft.epage=141&rft_id=info:doi/10.1002%2Fajmg.a.36802&rft.externalDBID=10.1002%252Fajmg.a.36802&rft.externalDocID=AJMGA36802
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1552-4825&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1552-4825&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1552-4825&client=summon