Evidence that an Isoform of Calpain-10 Is a Regulator of Exocytosis in Pancreatic β-Cells

Calpain-10 (CAPN10) is the first type 2 diabetes susceptibility gene to be identified through a genome scan, with polymorphisms being associated with altered CAPN10 expression. Functional data have been hitherto elusive, but we report here a corresponding increase between CAPN10 expression level and...

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Bibliographic Details
Published in:	Molecular endocrinology (Baltimore, Md.) Vol. 19; no. 1; pp. 213 - 224
Main Authors:	Marshall, Catriona, Hitman, Graham A, Partridge, Christopher J, Clark, Anne, Ma, Hong, Shearer, Thomas R, Turner, Mark D
Format:	Journal Article
Language:	English
Published:	United States Endocrine Society 01-01-2005 Oxford University Press
Subjects:	Antigens, Surface - metabolism Calcium - pharmacology Calpain - antagonists & inhibitors Calpain - metabolism Cell Line Cell Membrane - enzymology Cytosol - enzymology Exocytosis - drug effects Gene Expression Regulation - drug effects Glucose - pharmacology Humans Immunohistochemistry Insulin - metabolism Insulin Secretion Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - enzymology Islets of Langerhans - metabolism Membrane Proteins - metabolism Nerve Tissue Proteins - metabolism Protein Binding Protein Isoforms - antagonists & inhibitors Protein Isoforms - metabolism Synaptosomal-Associated Protein 25 Syntaxin 1
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