B- and T-cell subpopulations in patients with severe idiopathic membranous nephropathy may predict an early response to rituximab

Primary membranous nephropathy (PMN) is characterized by antibodies to the podocyte, but little is known about B- and T-cell populations and their response to rituximab is controversial. To help resolve this we compared 33 lymphocyte subpopulations and 27 cytokines/chemokines in 25 patients with sev...

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Bibliographic Details
Published in:	Kidney international Vol. 92; no. 1; p. 227
Main Authors:	Rosenzwajg, Michelle, Languille, Eva, Debiec, Hanna, Hygino, Joana, Dahan, Karine, Simon, Tabassome, Klatzmann, David, Ronco, Pierre
Format:	Journal Article
Language:	English
Published:	United States 01-07-2017
Subjects:	Adult Aged Autoantibodies - blood B-Lymphocyte Subsets - drug effects B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism Biomarkers - blood CD4 Lymphocyte Count CD56 Antigen - blood Female Glomerulonephritis, Membranous - blood Glomerulonephritis, Membranous - diagnosis Glomerulonephritis, Membranous - drug therapy Glomerulonephritis, Membranous - immunology GPI-Linked Proteins - blood Humans Immunophenotyping Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Interleukin-2 Receptor alpha Subunit - blood Interleukin-5 - blood Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Male Middle Aged Paris Phenotype Predictive Value of Tests Receptors, IgG - blood Rituximab - adverse effects Rituximab - therapeutic use Severity of Illness Index T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Time Factors Treatment Outcome Tumor Necrosis Factor-alpha - blood regulatory T cells natural killer cells TNF-α memory B cells membranous nephropathy rituximab
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