Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients

• Published in: The New England journal of medicine Vol. 389; no. 17; pp. 1590 - 1600
• Main Authors: Misset, Benoît, Piagnerelli, Michael, Hoste, Eric, Dardenne, Nadia, Grimaldi, David, Michaux, Isabelle, De Waele, Elisabeth, Dumoulin, Alexander, Jorens, Philippe G., van der Hauwaert, Emmanuel, Vallot, Frédéric, Lamote, Stoffel, Swinnen, Walter, De Schryver, Nicolas, Fraipont, Vincent, de Mey, Nathalie, Dauby, Nicolas, Layios, Nathalie, Mesland, Jean-Baptiste, Meyfroidt, Geert, Moutschen, Michel, Compernolle, Veerle, Gothot, André, Desmecht, Daniel, Taveira da Silva Pereira, Maria I., Garigliany, Mutien, Najdovski, Tome, Bertrand, Axelle, Donneau, Anne-Françoise, Laterre, Pierre-François
• Format: Journal Article Web Resource
• Language: English
• Published: United States Massachusetts Medical Society 26-10-2023
• Subjects: Adult; Anesthesia & intensive care; Anesthésie & soins intensifs; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - therapeutic use; Confidence intervals; Consent; Coronavirus; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - immunology; COVID-19 - therapy; COVID-19 Serotherapy; Critical Care; Critical Care General; General Medicine; Global Health; Human health sciences; Humans; Immunization; Immunization (passive); Infectious Disease; Infectious Disease General; Intensive care; Mechanical Ventilation; Missing data; Mortality; Pandemics; Patients; Plasma; Pulmonary; Respiration, Artificial; Respiratory Distress Syndrome - etiology; Respiratory Distress Syndrome - immunology; Respiratory Distress Syndrome - therapy; SARS-CoV-2; Sciences de la santé humaine; Severe acute respiratory syndrome coronavirus 2; Software; Statistical analysis; Treatment Outcome; Ventilators; Viral Infections; Belgium
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa2209502

In this open-label, randomized trial in patients newly receiving mechanical ventilatory support for Covid-19–associated ARDS, those who received convalescent plasma had lower 28-day mortality than those who received standard care.