Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam

• Published in: Acta cirurgica brasileira Vol. 28; no. 3; pp. 185 - 189
• Main Authors: Botelho, Nara Macedo, Corrêa, Suelen Costa, Lobato, Rodolfo Costa, Teixeira, Renan Kleber Costa, Quaresma, Juarez Antônio Simões
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01-03-2013
• Subjects: Animals; Antineoplastic Agents, Phytogenic - therapeutic use; Balsams - therapeutic use; Carcinoma 256, Walker; Carcinoma 256, Walker - drug therapy; Carcinoma 256, Walker - immunology; Carcinoma 256, Walker - pathology; Cervix Uteri; Cervix Uteri - drug effects; Cervix Uteri - immunology; Cervix Uteri - pathology; Female; Immunohistochemistry; Random Allocation; Rats; Rats, Wistar; Reproducibility of Results; Time Factors; Treatment Outcome
• ISSN: 0102-8650; 1678-2674; 0102-8650
• DOI: 10.1590/S0102-86502013000300005

To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis).
The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells.
It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage).
Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.