Effects of Thyroparathyroidectomy and Thyrocalcitonin on the Bone Acid Phosphatase Activity and the Serum Calcium Concentration in Rats treated with Lead Acetate

• Published in: Chemical & pharmaceutical bulletin Vol. 23; no. 8; pp. 1882 - 1884
• Main Authors: YAMAGUCHI, MASAYOSHI, YAMAMOTO, TAKEO
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01-01-1975; Japan Science and Technology Agency
• Subjects: Acid Phosphatase - metabolism; Animals; Bone and Bones - enzymology; Calcitonin - pharmacology; Calcium - blood; Lead - pharmacology; Male; Parathyroid Glands - physiology; Rats; Thyroidectomy
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.23.1882

The effect of thyroparathyroidectomy and thyrocalcitonin on the bone acid phosphatase activity and the serum calcium level in lead-treated rats was studied. Lead administration to intact rats produced a significant increase in bone acid phosphatase activity and serum calcium level. Thyroparathyroidectomy significantly decreased the bone acid phosphatase activity and the serum calcium level in intact normal rats. However, lead administration prevented this reduction. Thyrocalcitonin injection significantly depressed the bone acid phosphatase activity and the serum calcium level elevated by the administration of lead to thyroparathyroidectomized rats and intact normal rats. The present results suggest that the increase in the bone acid phosphatase activity and the serum calcium level caused by lead administration is independent upon the action by parathyroid hormone.