Ipsilateral Motor Pathways and Transcallosal Inhibition During Lower Limb Movement After Stroke
Background Stroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and alterations in transcallosal inhibition. Few studies have evaluated these factors during dynamic, bilateral lower limb movements, and it is unclear w...
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| Published in: | Neurorehabilitation and neural repair Vol. 35; no. 4; pp. 367 - 378 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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Los Angeles, CA
SAGE Publications
01-04-2021
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| Abstract | Background
Stroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and alterations in transcallosal inhibition. Few studies have evaluated these factors during dynamic, bilateral lower limb movements, and it is unclear whether they relate to functional outcomes.
Objective
Determine if lower limb ipsilateral excitability and transcallosal inhibition after stroke depend on target limb, task, or number of limbs involved, and whether these factors are related to clinical measures.
Methods
In 29 individuals with stroke, ipsilateral and contralateral responses to transcranial magnetic stimulation were measured in the paretic and nonparetic tibialis anterior during dynamic (unilateral or bilateral ankle dorsiflexion/plantarflexion) and isometric (unilateral dorsiflexion) conditions. Relative ipsilateral excitability and transcallosal inhibition were assessed. Fugl-Meyer, ankle movement accuracy, and walking characteristics were assessed.
Results
Relative ipsilateral excitability was greater during dynamic than isometric conditions in the paretic limb (P ≤ .02) and greater in the paretic than the nonparetic limb during dynamic conditions (P ≤ .004). Transcallosal inhibition was greater in the ipsilesional than contralesional hemisphere (P = .002) and during dynamic than isometric conditions (P = .03). Greater ipsilesional transcallosal inhibition was correlated with better ankle movement accuracy (R2 = 0.18, P = .04). Greater contralateral excitability to the nonparetic limb was correlated with improved walking symmetry (R2 = 0.19, P = .03).
Conclusions
Ipsilateral pathways have increased excitability to the paretic limb, particularly during dynamic tasks. Transcallosal inhibition is greater in the ipsilesional than contralesional hemisphere and during dynamic than isometric tasks. Ipsilateral pathways and transcallosal inhibition may influence walking asymmetry and ankle movement accuracy. |
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| AbstractList | Stroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and alterations in transcallosal inhibition. Few studies have evaluated these factors during dynamic, bilateral lower limb movements, and it is unclear whether they relate to functional outcomes.
Determine if lower limb ipsilateral excitability and transcallosal inhibition after stroke depend on target limb, task, or number of limbs involved, and whether these factors are related to clinical measures.
In 29 individuals with stroke, ipsilateral and contralateral responses to transcranial magnetic stimulation were measured in the paretic and nonparetic tibialis anterior during dynamic (unilateral or bilateral ankle dorsiflexion/plantarflexion) and isometric (unilateral dorsiflexion) conditions. Relative ipsilateral excitability and transcallosal inhibition were assessed. Fugl-Meyer, ankle movement accuracy, and walking characteristics were assessed.
Relative ipsilateral excitability was greater during dynamic than isometric conditions in the paretic limb (
≤ .02) and greater in the paretic than the nonparetic limb during dynamic conditions (
≤ .004). Transcallosal inhibition was greater in the ipsilesional than contralesional hemisphere (
= .002) and during dynamic than isometric conditions (
= .03). Greater ipsilesional transcallosal inhibition was correlated with better ankle movement accuracy (
= 0.18,
= .04). Greater contralateral excitability to the nonparetic limb was correlated with improved walking symmetry (
= 0.19,
= .03).
Ipsilateral pathways have increased excitability to the paretic limb, particularly during dynamic tasks. Transcallosal inhibition is greater in the ipsilesional than contralesional hemisphere and during dynamic than isometric tasks. Ipsilateral pathways and transcallosal inhibition may influence walking asymmetry and ankle movement accuracy. Background Stroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and alterations in transcallosal inhibition. Few studies have evaluated these factors during dynamic, bilateral lower limb movements, and it is unclear whether they relate to functional outcomes. Objective Determine if lower limb ipsilateral excitability and transcallosal inhibition after stroke depend on target limb, task, or number of limbs involved, and whether these factors are related to clinical measures. Methods In 29 individuals with stroke, ipsilateral and contralateral responses to transcranial magnetic stimulation were measured in the paretic and nonparetic tibialis anterior during dynamic (unilateral or bilateral ankle dorsiflexion/plantarflexion) and isometric (unilateral dorsiflexion) conditions. Relative ipsilateral excitability and transcallosal inhibition were assessed. Fugl-Meyer, ankle movement accuracy, and walking characteristics were assessed. Results Relative ipsilateral excitability was greater during dynamic than isometric conditions in the paretic limb (P ≤ .02) and greater in the paretic than the nonparetic limb during dynamic conditions (P ≤ .004). Transcallosal inhibition was greater in the ipsilesional than contralesional hemisphere (P = .002) and during dynamic than isometric conditions (P = .03). Greater ipsilesional transcallosal inhibition was correlated with better ankle movement accuracy (R2 = 0.18, P = .04). Greater contralateral excitability to the nonparetic limb was correlated with improved walking symmetry (R2 = 0.19, P = .03). Conclusions Ipsilateral pathways have increased excitability to the paretic limb, particularly during dynamic tasks. Transcallosal inhibition is greater in the ipsilesional than contralesional hemisphere and during dynamic than isometric tasks. Ipsilateral pathways and transcallosal inhibition may influence walking asymmetry and ankle movement accuracy. BACKGROUNDStroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and alterations in transcallosal inhibition. Few studies have evaluated these factors during dynamic, bilateral lower limb movements, and it is unclear whether they relate to functional outcomes. OBJECTIVEDetermine if lower limb ipsilateral excitability and transcallosal inhibition after stroke depend on target limb, task, or number of limbs involved, and whether these factors are related to clinical measures. METHODSIn 29 individuals with stroke, ipsilateral and contralateral responses to transcranial magnetic stimulation were measured in the paretic and nonparetic tibialis anterior during dynamic (unilateral or bilateral ankle dorsiflexion/plantarflexion) and isometric (unilateral dorsiflexion) conditions. Relative ipsilateral excitability and transcallosal inhibition were assessed. Fugl-Meyer, ankle movement accuracy, and walking characteristics were assessed. RESULTSRelative ipsilateral excitability was greater during dynamic than isometric conditions in the paretic limb (P ≤ .02) and greater in the paretic than the nonparetic limb during dynamic conditions (P ≤ .004). Transcallosal inhibition was greater in the ipsilesional than contralesional hemisphere (P = .002) and during dynamic than isometric conditions (P = .03). Greater ipsilesional transcallosal inhibition was correlated with better ankle movement accuracy (R2 = 0.18, P = .04). Greater contralateral excitability to the nonparetic limb was correlated with improved walking symmetry (R2 = 0.19, P = .03). CONCLUSIONSIpsilateral pathways have increased excitability to the paretic limb, particularly during dynamic tasks. Transcallosal inhibition is greater in the ipsilesional than contralesional hemisphere and during dynamic than isometric tasks. Ipsilateral pathways and transcallosal inhibition may influence walking asymmetry and ankle movement accuracy. |
| Author | Madhavan, Sangeetha Cleland, Brice T. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33703951$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_gaitpost_2022_10_013 crossref_primary_10_3390_brainsci12081055 crossref_primary_10_1111_ejn_15753 crossref_primary_10_3389_fnhum_2022_896367 |
| Cites_doi | 10.1093/brain/awg145 10.1038/nrneurol.2014.162 10.2340/165019771995175182 10.1007/s12975-017-0551-5 10.1016/j.brainres.2014.07.021 10.1097/00001756-199607290-00012 10.1093/brain/118.2.429 10.1155/2016/4071620 10.1016/j.clinph.2014.12.018 10.1016/j.clinph.2007.10.014 10.1016/j.brs.2009.06.005 10.3389/fnhum.2016.00681 10.1097/01.WNP.0000150975.83249.71 10.1098/rspb.1965.0016 10.1191/0269215503cr662oa 10.1007/BF00231167 10.1007/s002210050878 10.1111/j.1460-9568.2010.07172.x 10.3389/fnhum.2013.00184 10.1093/brain/awx384 10.1016/j.neuroimage.2011.01.014 10.1016/j.clinph.2015.02.001 10.1007/s00221-014-4183-7 10.1016/j.clinph.2014.01.034 10.1111/ene.12949 10.1016/j.neuroimage.2008.03.048 10.1002/ana.25452 10.1177/1545968308315997 10.1016/j.apmr.2013.12.023 10.2340/1650197771331 10.1177/1073858405283392 10.1007/s002210050749 10.1007/s00221-010-2511-0 10.1080/096382899297684 10.1155/2012/627816 10.3389/fnhum.2016.00049 10.1161/01.STR.32.6.1304 10.1093/brain/120.9.1579 10.1016/j.brs.2017.03.008 10.1016/j.clinph.2012.04.026 10.1053/apmr.2002.33984 10.1016/j.neuroimage.2005.06.033 10.1002/ana.10848 10.1007/s00422-004-0539-6 10.1002/ana.21228 10.1113/JP278779 10.1097/00001756-200307180-00009 10.1016/j.brs.2015.06.015 10.1016/S0022-510X(96)00222-5 10.1016/S0003-9993(95)80038-7 10.1113/jphysiol.1992.sp019243 10.1111/j.1460-9568.2010.07364.x 10.1111/j.1468-1331.2008.02168.x 10.1016/j.neulet.2016.05.041 10.1111/j.1469-7793.1999.0895p.x 10.1016/j.brs.2017.01.006 10.2522/ptj.20130175 |
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| References | Sriraman, Oishi, Madhavan 2014; 1581 Ejaz, Xu, Branscheidt 2018; 141 Madhavan, Stinear 2010; 3 Ferbert, Priori, Rothwell, Day, Colebatch, Marsden 1992; 453 Katz, Miledi 1965; 161 Jørgensen, Nakayama, Raaschou, Olsen 1995; 76 Jayaram, Stagg, Esser, Kischka, Stinear, Johansen-Berg 2012; 123 Madhavan, Weber, Stinear 2011; 209 Rehme, Eickhoff, Wang, Fink, Grefkes 2011; 55 Wiegel, Kurz, Leukel 2020; 598 Plow, Sankarasubramanian, Cunningham 2016; 2016 Jankowska, Edgley 2006; 12 Mayo, Wood-Dauphinee, Ahmed 1999; 21 Madhavan, Rogers, Stinear 2010; 32 Mang, Borich, Brodie 2015; 126 Ludemann-Podubecka, Bosl, Nowak 2016; 23 English, Manns, Tucak, Bernhardt 2014; 94 Fugl-Meyer, Jaasko, Leyman, Olsson, Steglind 1975; 7 Desrosiers, Malouin, Bourbonnais, Richards, Rochette, Bravo 2003; 17 Chen, Cros, Curra 2008; 119 Benecke, Meyer, Freund 1991; 83 Takechi, Matsunaga, Nakanishi 2014; 125 Thickbroom, Phillips, Morris, Byrnes, Sacco, Mastaglia 1999; 126 Netz, Lammers, Homberg 1997; 120 Stinear, Petoe, Byblow 2015; 8 Ziemann, Ishii, Borgheresi 1999; 518 Duque, Hummel, Celnik, Murase, Mazzocchio, Cohen 2005; 28 Boddington, Reynolds 2017; 10 Chen, Lozano, Ashby 1999; 128 Keisker, Hepp-Reymond, Blickenstorfer, Kollias 2010; 31 Daffertshofer, Peper, Beek 2005; 92 Alagona, Delvaux, Gerard 2001; 32 Xu, Branscheidt, Schambra 2019; 85 Meyer, Roricht, Grafin von Einsiedel, Kruggel, Weindl 1995; 118 Boroojerdi, Diefenbach, Ferbert 1996; 144 Dickstein 2008; 22 Di Pino, Pellegrino, Assenza 2014; 10 van Kuijk, Pasman, Geurts, Hendricks 2005; 22 Caramia, Iani, Bernardi 1996; 7 Rossini, Burke, Chen 2015; 126 Ward, Brown, Thompson, Frackowiak 2003; 126 Fleming, Newham 2017; 10 Bradnam, Stinear, Byblow 2013; 7 Turnbull, Charteris, Wall 1995; 27 Grefkes, Eickhoff, Nowak, Dafotakis, Fink 2008; 41 Davidson, Bolic, Tremblay 2016; 10 Mayo, Wood-Dauphinee, Cote, Durcan, Carlton 2002; 83 Alawieh, Tomlinson, Adkins, Kautz, Feng 2017; 8 Grefkes, Nowak, Eickhoff 2008; 63 Dimyan, Perez, Auh, Tarula, Wilson, Cohen 2014; 95 Bestmann, Krakauer 2015; 233 Beaule, Tremblay, Theoret 2012; 2012 Kim, Jang, Chang, Byun, Son, Ahn 2003; 14 Murase, Duque, Mazzocchio, Cohen 2004; 55 Misawa, Kuwabara, Matsuda, Honma, Ono, Hattori 2008; 15 McDonnell, Stinear 2017; 10 Sivaramakrishnan, Tahara-Eckl, Madhavan 2016; 627 bibr56-1545968321999049 bibr48-1545968321999049 bibr22-1545968321999049 bibr9-1545968321999049 bibr14-1545968321999049 bibr57-1545968321999049 bibr55-1545968321999049 bibr31-1545968321999049 bibr12-1545968321999049 bibr38-1545968321999049 bibr21-1545968321999049 bibr39-1545968321999049 bibr13-1545968321999049 bibr47-1545968321999049 bibr8-1545968321999049 bibr30-1545968321999049 bibr24-1545968321999049 bibr29-1545968321999049 bibr11-1545968321999049 bibr37-1545968321999049 bibr40-1545968321999049 bibr3-1545968321999049 bibr53-1545968321999049 bibr16-1545968321999049 bibr6-1545968321999049 bibr1-1545968321999049 bibr50-1545968321999049 bibr19-1545968321999049 bibr32-1545968321999049 bibr45-1545968321999049 bibr43-1545968321999049 bibr5-1545968321999049 bibr51-1545968321999049 bibr35-1545968321999049 bibr27-1545968321999049 bibr18-1545968321999049 bibr42-1545968321999049 bibr44-1545968321999049 bibr17-1545968321999049 bibr25-1545968321999049 bibr52-1545968321999049 bibr4-1545968321999049 bibr26-1545968321999049 bibr34-1545968321999049 bibr7-1545968321999049 bibr54-1545968321999049 bibr46-1545968321999049 bibr33-1545968321999049 bibr36-1545968321999049 bibr49-1545968321999049 bibr10-1545968321999049 bibr20-1545968321999049 bibr23-1545968321999049 Turnbull GI (bibr2-1545968321999049) 1995; 27 bibr28-1545968321999049 bibr41-1545968321999049 bibr15-1545968321999049 |
| References_xml | – volume: 32 start-page: 1304 year: 2001 end-page: 1309 article-title: Ipsilateral motor responses to focal transcranial magnetic stimulation in healthy subjects and acute-stroke patients publication-title: Stroke contributor: fullname: Gerard – volume: 10 start-page: 214 year: 2017 end-page: 222 article-title: Targeting interhemispheric inhibition with neuromodulation to enhance stroke rehabilitation publication-title: Brain Stimul contributor: fullname: Reynolds – volume: 126 start-page: 1959 year: 2015 end-page: 1971 article-title: Diffusion imaging and transcranial magnetic stimulation assessment of transcallosal pathways in chronic stroke publication-title: Clin Neurophysiol contributor: fullname: Brodie – volume: 161 start-page: 483 year: 1965 end-page: 495 article-title: The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction publication-title: Proc R Soc Lond B Biol Sci contributor: fullname: Miledi – volume: 22 start-page: 10 year: 2005 end-page: 24 article-title: How salient is the silent period? The role of the silent period in the prognosis of upper extremity motor recovery after severe stroke publication-title: J Clin Neurophysiol contributor: fullname: Hendricks – volume: 22 start-page: 649 year: 2008 end-page: 660 article-title: Rehabilitation of gait speed after stroke: a critical review of intervention approaches publication-title: Neurorehabil Neural Repair contributor: fullname: Dickstein – volume: 63 start-page: 236 year: 2008 end-page: 246 article-title: Cortical connectivity after subcortical stroke assessed with functional magnetic resonance imaging publication-title: Ann Neurol contributor: fullname: Eickhoff – volume: 126 start-page: 1071 year: 2015 end-page: 1107 article-title: Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee publication-title: Clin Neurophysiol contributor: fullname: Chen – volume: 120 start-page: 1579 year: 1997 end-page: 1586 article-title: Reorganization of motor output in the non-affected hemisphere after stroke publication-title: Brain contributor: fullname: Homberg – volume: 85 start-page: 502 year: 2019 end-page: 513 article-title: Rethinking interhemispheric imbalance as a target for stroke neurorehabilitation publication-title: Ann Neurol contributor: fullname: Schambra – volume: 7 start-page: 184 year: 2013 article-title: Ipsilateral motor pathways after stroke: implications for non-invasive brain stimulation publication-title: Front Hum Neurosci contributor: fullname: Byblow – volume: 92 start-page: 101 year: 2005 end-page: 109 article-title: Stabilization of bimanual coordination due to active interhemispheric inhibition: a dynamical account publication-title: Biol Cybern contributor: fullname: Beek – volume: 144 start-page: 160 year: 1996 end-page: 170 article-title: Transcallosal inhibition in cortical and subcortical cerebral vascular lesions publication-title: J Neurol Sci contributor: fullname: Ferbert – volume: 55 start-page: 1147 year: 2011 end-page: 1158 article-title: Dynamic causal modeling of cortical activity from the acute to the chronic stage after stroke publication-title: Neuroimage contributor: fullname: Grefkes – volume: 3 start-page: 42 year: 2010 article-title: Focal and bi-directional modulation of lower limb motor cortex using anodal transcranial direct current stimulation publication-title: Brain Stimul contributor: fullname: Stinear – volume: 7 start-page: 13 year: 1975 end-page: 31 article-title: The post-stroke hemiplegic patient. 1. A method for evaluation of physical performance publication-title: Scand J Rehabil Med contributor: fullname: Steglind – volume: 233 start-page: 679 year: 2015 end-page: 689 article-title: The uses and interpretations of the motor-evoked potential for understanding behaviour publication-title: Exp Brain Res contributor: fullname: Krakauer – volume: 83 start-page: 419 year: 1991 end-page: 426 article-title: Reorganisation of descending motor pathways in patients after hemispherectomy and severe hemispheric lesions demonstrated by magnetic brain stimulation publication-title: Exp Brain Res contributor: fullname: Freund – volume: 598 start-page: 1235 year: 2020 end-page: 1251 article-title: Evidence that distinct human primary motor cortex circuits control discrete and rhythmic movements publication-title: J Physiol contributor: fullname: Leukel – volume: 10 start-page: 597 year: 2014 end-page: 608 article-title: Modulation of brain plasticity in stroke: a novel model for neurorehabilitation publication-title: Nat Rev Neurol contributor: fullname: Assenza – volume: 76 start-page: 27 year: 1995 end-page: 32 article-title: Recovery of walking function in stroke patients: the Copenhagen Stroke Study publication-title: Arch Phys Med Rehabil contributor: fullname: Olsen – volume: 21 start-page: 258 year: 1999 end-page: 268 article-title: Disablement following stroke publication-title: Disabil Rehabil contributor: fullname: Ahmed – volume: 627 start-page: 30 year: 2016 end-page: 35 article-title: Spatial localization and distribution of the TMS-related “hotspot” of the tibialis anterior muscle representation in the healthy and post-stroke motor cortex publication-title: Neurosci Lett contributor: fullname: Madhavan – volume: 10 start-page: 49 year: 2016 article-title: Predicting modulation in corticomotor excitability and in transcallosal inhibition in response to anodal transcranial direct current stimulation publication-title: Front Hum Neurosci contributor: fullname: Tremblay – volume: 123 start-page: 2422 year: 2012 end-page: 2428 article-title: Relationships between functional and structural corticospinal tract integrity and walking post stroke publication-title: Clin Neurophysiol contributor: fullname: Johansen-Berg – volume: 17 start-page: 666 year: 2003 end-page: 673 article-title: Arm and leg impairments and disabilities after stroke rehabilitation: relation to handicap publication-title: Clin Rehabil contributor: fullname: Bravo – volume: 12 start-page: 67 year: 2006 end-page: 79 article-title: How can corticospinal tract neurons contribute to ipsilateral movements? A question with implications for recovery of motor functions publication-title: Neuroscientist contributor: fullname: Edgley – volume: 28 start-page: 940 year: 2005 end-page: 946 article-title: Transcallosal inhibition in chronic subcortical stroke publication-title: Neuroimage contributor: fullname: Cohen – volume: 118 start-page: 429 year: 1995 end-page: 440 article-title: Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum publication-title: Brain contributor: fullname: Weindl – volume: 2012 start-page: 627816 year: 2012 article-title: Interhemispheric control of unilateral movement publication-title: Neural Plast contributor: fullname: Theoret – volume: 8 start-page: 529 year: 2017 end-page: 540 article-title: Preclinical and clinical evidence on ipsilateral corticospinal projections: implication for motor recovery publication-title: Transl Stroke Res contributor: fullname: Feng – volume: 14 start-page: 1329 year: 2003 end-page: 1332 article-title: Bilateral primary sensori-motor cortex activation of post-stroke mirror movements: an fMRI study publication-title: Neuroreport contributor: fullname: Ahn – volume: 32 start-page: 1032 year: 2010 end-page: 1039 article-title: A paradox: after stroke, the non-lesioned lower limb motor cortex may be maladaptive publication-title: Eur J Neurosci contributor: fullname: Stinear – volume: 41 start-page: 1382 year: 2008 end-page: 1394 article-title: Dynamic intra- and interhemispheric interactions during unilateral and bilateral hand movements assessed with fMRI and DCM publication-title: Neuroimage contributor: fullname: Fink – volume: 8 start-page: 1183 year: 2015 end-page: 1190 article-title: Primary motor cortex excitability during recovery after stroke: implications for neuromodulation publication-title: Brain Stimul contributor: fullname: Byblow – volume: 95 start-page: 849 year: 2014 end-page: 856 article-title: Nonparetic arm force does not overinhibit the paretic arm in chronic poststroke hemiparesis publication-title: Arch Phys Med Rehabil contributor: fullname: Cohen – volume: 1581 start-page: 23 year: 2014 end-page: 29 article-title: Timing-dependent priming effects of tDCS on ankle motor skill learning publication-title: Brain Res contributor: fullname: Madhavan – volume: 7 start-page: 1756 year: 1996 end-page: 1760 article-title: Cerebral plasticity after stroke as revealed by ipsilateral responses to magnetic stimulation publication-title: Neuroreport contributor: fullname: Bernardi – volume: 55 start-page: 400 year: 2004 end-page: 409 article-title: Influence of interhemispheric interactions on motor function in chronic stroke publication-title: Ann Neurol contributor: fullname: Cohen – volume: 2016 start-page: 4071620 year: 2016 article-title: Models to tailor brain stimulation therapies in stroke publication-title: Neural Plast contributor: fullname: Cunningham – volume: 15 start-page: 706 year: 2008 end-page: 711 article-title: The ipsilateral cortico-spinal tract is activated after hemiparetic stroke publication-title: Eur J Neurol contributor: fullname: Hattori – volume: 94 start-page: 185 year: 2014 end-page: 196 article-title: Physical activity and sedentary behaviors in people with stroke living in the community: a systematic review publication-title: Phys Ther contributor: fullname: Bernhardt – volume: 83 start-page: 1035 year: 2002 end-page: 1042 article-title: Activity, participation, and quality of life 6 months poststroke publication-title: Arch Phys Med Rehabil contributor: fullname: Carlton – volume: 209 start-page: 9 year: 2011 end-page: 17 article-title: Non-invasive brain stimulation enhances fine motor control of the hemiparetic ankle: implications for rehabilitation publication-title: Exp Brain Res contributor: fullname: Stinear – volume: 10 start-page: 681 year: 2017 article-title: Reliability of transcallosal inhibition in healthy adults publication-title: Front Hum Neurosci contributor: fullname: Newham – volume: 31 start-page: 1483 year: 2010 end-page: 1491 article-title: Differential representation of dynamic and static power grip force in the sensorimotor network publication-title: Eur J Neurosci contributor: fullname: Kollias – volume: 126 start-page: 1430 year: 2003 end-page: 1448 article-title: Neural correlates of outcome after stroke: a cross-sectional fMRI study publication-title: Brain contributor: fullname: Frackowiak – volume: 119 start-page: 504 year: 2008 end-page: 532 article-title: The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee publication-title: Clin Neurophysiol contributor: fullname: Curra – volume: 128 start-page: 539 year: 1999 end-page: 542 article-title: Mechanism of the silent period following transcranial magnetic stimulation. Evidence from epidural recordings publication-title: Exp Brain Res contributor: fullname: Ashby – volume: 23 start-page: 823 year: 2016 end-page: 830 article-title: Inhibition of the contralesional dorsal premotor cortex improves motor function of the affected hand following stroke publication-title: Eur J Neurol contributor: fullname: Nowak – volume: 518 start-page: 895 year: 1999 end-page: 906 article-title: Dissociation of the pathways mediating ipsilateral and contralateral motor-evoked potentials in human hand and arm muscles publication-title: J Physiol contributor: fullname: Borgheresi – volume: 10 start-page: 721 year: 2017 end-page: 734 article-title: TMS measures of motor cortex function after stroke: a meta-analysis publication-title: Brain Stimul contributor: fullname: Stinear – volume: 141 start-page: 837 year: 2018 end-page: 847 article-title: Evidence for a subcortical origin of mirror movements after stroke: a longitudinal study publication-title: Brain contributor: fullname: Branscheidt – volume: 126 start-page: 431 year: 1999 end-page: 438 article-title: Differences in functional magnetic resonance imaging of sensorimotor cortex during static and dynamic finger flexion publication-title: Exp Brain Res contributor: fullname: Mastaglia – volume: 453 start-page: 525 year: 1992 end-page: 546 article-title: Interhemispheric inhibition of the human motor cortex publication-title: J Physiol contributor: fullname: Marsden – volume: 125 start-page: 2055 year: 2014 end-page: 2069 article-title: Longitudinal changes of motor cortical excitability and transcallosal inhibition after subcortical stroke publication-title: Clin Neurophysiol contributor: fullname: Nakanishi – volume: 27 start-page: 175 year: 1995 end-page: 182 article-title: A comparison of the range of walking speeds between normal and hemiplegic subjects publication-title: Scand J Rehabil Med contributor: fullname: Wall – ident: bibr10-1545968321999049 doi: 10.1093/brain/awg145 – ident: bibr55-1545968321999049 doi: 10.1038/nrneurol.2014.162 – volume: 27 start-page: 175 year: 1995 ident: bibr2-1545968321999049 publication-title: Scand J Rehabil Med doi: 10.2340/165019771995175182 contributor: fullname: Turnbull GI – ident: bibr9-1545968321999049 doi: 10.1007/s12975-017-0551-5 – ident: bibr31-1545968321999049 doi: 10.1016/j.brainres.2014.07.021 – ident: bibr12-1545968321999049 doi: 10.1097/00001756-199607290-00012 – ident: bibr33-1545968321999049 doi: 10.1093/brain/118.2.429 – ident: bibr56-1545968321999049 doi: 10.1155/2016/4071620 – ident: bibr52-1545968321999049 doi: 10.1016/j.clinph.2014.12.018 – ident: bibr53-1545968321999049 doi: 10.1016/j.clinph.2007.10.014 – ident: bibr29-1545968321999049 doi: 10.1016/j.brs.2009.06.005 – ident: bibr34-1545968321999049 doi: 10.3389/fnhum.2016.00681 – ident: bibr54-1545968321999049 doi: 10.1097/01.WNP.0000150975.83249.71 – ident: bibr41-1545968321999049 doi: 10.1098/rspb.1965.0016 – ident: bibr5-1545968321999049 doi: 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Stroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and... Stroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and alterations in... BACKGROUNDStroke rehabilitation may be improved with a better understanding of the contribution of ipsilateral motor pathways to the paretic limb and... |
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| Title | Ipsilateral Motor Pathways and Transcallosal Inhibition During Lower Limb Movement After Stroke |
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