4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation
Taste perception plays a crucial role in health and well-being but can be compromised by conditions such as diabetes mellitus (DM). This study delved into the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, particularly in relation to DM-induced taste issues. Two primary rat...
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| Published in: | Applied sciences Vol. 13; no. 21; p. 11617 |
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| Abstract | Taste perception plays a crucial role in health and well-being but can be compromised by conditions such as diabetes mellitus (DM). This study delved into the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, particularly in relation to DM-induced taste issues. Two primary rat groups were investigated: healthy rats and streptozotocin (STZ)-induced diabetic rats. Each group was further divided into control and experimental subsets, with the experimental group receiving 4-HR injections. A histological analysis of the circumvallate papillae (CVP) highlighted significant taste bud deterioration in the STZ subgroup, including loss of cellular content and a deviation from their typical morphology. Quantitatively, the control group had a mean of 39.6 ± 14.3 taste bud pores/mm2, contrasting with the 4HR, STZ, and STZ/4HR groups, which had means of 33.7 ± 14.2, 20.3 ± 6.1, and 28.0 ± 8.3, respectively. Additionally, a TUNEL assay and IHC staining for c-caspase-3 both identified increased apoptotic cells in the STZ subgroup, with the mean number of apoptotic cells per taste bud profile being notably higher in the STZ group at 3.2 ± 1.6. This study underscores the profound impact of diabetes on taste bud physiology and the potential therapeutic benefits of 4-HR. Further research is essential to delve deeper into its mechanisms and to ascertain optimal dosages, with the aim of enhancing the quality of life of diabetic patients. |
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| AbstractList | Taste perception plays a crucial role in health and well-being but can be compromised by conditions such as diabetes mellitus (DM). This study delved into the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, particularly in relation to DM-induced taste issues. Two primary rat groups were investigated: healthy rats and streptozotocin (STZ)-induced diabetic rats. Each group was further divided into control and experimental subsets, with the experimental group receiving 4-HR injections. A histological analysis of the circumvallate papillae (CVP) highlighted significant taste bud deterioration in the STZ subgroup, including loss of cellular content and a deviation from their typical morphology. Quantitatively, the control group had a mean of 39.6 ± 14.3 taste bud pores/mm2, contrasting with the 4HR, STZ, and STZ/4HR groups, which had means of 33.7 ± 14.2, 20.3 ± 6.1, and 28.0 ± 8.3, respectively. Additionally, a TUNEL assay and IHC staining for c-caspase-3 both identified increased apoptotic cells in the STZ subgroup, with the mean number of apoptotic cells per taste bud profile being notably higher in the STZ group at 3.2 ± 1.6. This study underscores the profound impact of diabetes on taste bud physiology and the potential therapeutic benefits of 4-HR. Further research is essential to delve deeper into its mechanisms and to ascertain optimal dosages, with the aim of enhancing the quality of life of diabetic patients. Taste perception plays a crucial role in health and well-being but can be compromised by conditions such as diabetes mellitus (DM). This study delved into the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, particularly in relation to DM-induced taste issues. Two primary rat groups were investigated: healthy rats and streptozotocin (STZ)-induced diabetic rats. Each group was further divided into control and experimental subsets, with the experimental group receiving 4-HR injections. A histological analysis of the circumvallate papillae (CVP) highlighted significant taste bud deterioration in the STZ subgroup, including loss of cellular content and a deviation from their typical morphology. Quantitatively, the control group had a mean of 39.6 ± 14.3 taste bud pores/mm[sup.2], contrasting with the 4HR, STZ, and STZ/4HR groups, which had means of 33.7 ± 14.2, 20.3 ± 6.1, and 28.0 ± 8.3, respectively. Additionally, a TUNEL assay and IHC staining for c-caspase-3 both identified increased apoptotic cells in the STZ subgroup, with the mean number of apoptotic cells per taste bud profile being notably higher in the STZ group at 3.2 ± 1.6. This study underscores the profound impact of diabetes on taste bud physiology and the potential therapeutic benefits of 4-HR. Further research is essential to delve deeper into its mechanisms and to ascertain optimal dosages, with the aim of enhancing the quality of life of diabetic patients. |
| Audience | Academic |
| Author | Kim, Seong-Gon Gaida, Dhouha Park, Young-Wook |
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| Cites_doi | 10.1016/j.numecd.2020.08.025 10.1007/s40618-017-0798-4 10.3390/ijms22168935 10.1679/aohc.72.91 10.1038/nature23299 10.1016/j.neulet.2014.08.012 10.3390/md21090462 10.1007/s10787-022-01086-9 10.1007/s00520-023-07598-6 10.21608/edj.2020.77535 10.3390/nu12041112 10.7554/eLife.64013 10.1016/j.jbiosc.2020.10.011 10.1002/bab.2233 10.1186/s40902-022-00334-w 10.1007/s00784-020-03299-0 10.1042/BJ20140213 10.1055/s-0031-1279714 10.1556/OH.2013.29570 10.1186/s40902-021-00326-2 10.3390/nu9070653 10.2147/DMSO.S318972 10.1080/10408398.2021.2015282 10.3389/fnut.2021.797920 10.4081/ejh.2022.3534 10.3390/ijms231911937 10.4103/0975-7406.137257 10.1038/s41467-023-41637-4 10.1089/ars.2012.4713 10.3390/nu12113284 10.3945/jn.111.157263 10.1016/j.diabres.2014.02.007 10.1161/CIRCRESAHA.110.223545 10.14202/vetworld.2022.2986-2996 10.1007/s11011-014-9626-0 10.1016/j.heliyon.2023.e19675 10.1186/s13005-022-00320-7 10.1016/j.sdentj.2021.09.012 10.1155/2016/3765173 10.3390/foods12071514 10.3390/molecules27248793 10.3390/antiox10030335 |
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| SubjectTerms | 4-hexylresorcinol Apoptosis Diabetes diabetes mellitus Glucose Health aspects Hydration Investigations Oxidative stress Physiological aspects Taste taste buds Taste disorders taste disturbance Tongue treatment Type 2 diabetes |
| Title | 4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation |
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