Neurotoxicological Assessment After Intracisternal Injection of Liposomal Bupivacaine in Rabbits

Experiments were performed on rabbits randomly assigned to intracisternally receive 0.3 mL of plain bupivacaine 5 mg/mL, liposomal bupivacaine 5 mg/mL, bupivacaine-free liposomes, or isotonic phosphate-buffered saline. Mechanical ventilation was initiated or intravenous dopamine was infused when res...

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Bibliographic Details
Published in:	Anesthesia and analgesia Vol. 85; no. 6; pp. 1331 - 1336
Main Authors:	Malinovsky, Jean-Marc, Benhamou, Dan, Alafandy, Mokarram, Mussini, Jean-Marie, Coussaert, Carine, Couarraze, Guy, Pinaud, Michel, Legros, Franz J.
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD International Anesthesia Research Society 01-12-1997 Lippincott
Subjects:	Anesthetics, Local - administration & dosage Anesthetics, Local - toxicity Animals Biological and medical sciences Blood-Brain Barrier - drug effects Bupivacaine - administration & dosage Bupivacaine - toxicity Drug Carriers Drug toxicity and drugs side effects treatment Injections, Spinal Liposomes Medical sciences Necrosis Pharmacology. Drug treatments Rabbits Spinal Cord - drug effects Spinal Cord - pathology Toxicity: nervous system and muscle Spinal cord Controlled release form Toxicity Intracisternal administration Rabbit Liposome Lagomorpha Blood brain barrier Local anesthetic Vertebrata Mammalia Regional anesthesia Bupivacaine Histopathology Animal Anilide
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