Natural Killer Cell Receptor Expression by Human First Trimester Decidual Granular Leukocytes and T-Lymphocytes
PROBLEM: Detailed analysis of the expression of natural killer (NK) cell activatory and inhibitory receptors by human decidual leukocyte subpopulations has not been undertaken. METHOD OF STUDY: Expression of the natural cytotoxicity receptors NKp30, NKp44 and NKp46 by decidual leukocytes were studie...
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| Published in: | American journal of reproductive immunology (1989) Vol. 48; no. 2; pp. 103 - 109 |
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| Main Authors: | , , , , , |
| Format: | Journal Article Conference Proceeding |
| Language: | English |
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Munksgaard International Publishers
01-08-2002
Blackwell |
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| Abstract | PROBLEM: Detailed analysis of the expression of natural killer (NK) cell activatory and inhibitory receptors by human decidual leukocyte subpopulations has not been undertaken.
METHOD OF STUDY: Expression of the natural cytotoxicity receptors NKp30, NKp44 and NKp46 by decidual leukocytes were studied by reverse transcriptase polymerase chain reaction. Expression of the killer cell Ig‐like receptors CD158a and CD158b on decidual T cells were studied by flow cytometry.
RESULTS: First trimester decidual leukocytes expressed mRNA for the NKp30 and NKp46 receptors but expression of NKp44, a marker of activated NK cells, was not detected. A mean of 11.8 and 15.8% of decidual T cells expressed CD158a or 158b, respectively, while only around 1% of peripheral blood T cells were CD158a+ or CD158b+.
CONCLUSIONS: Like peripheral blood NK cells, decidual NK cells express the natural cytotoxicity receptors NKp30 and NKp46 but the significance of this will not become apparent until ligands for these molecules have been identified. Only a minority of decidual T cells express CD158, indicating that this is not a mechanism for inhibition of cytotoxicity mediated by all decidual T cells. |
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| AbstractList | PROBLEM: Detailed analysis of the expression of natural killer (NK) cell activatory and inhibitory receptors by human decidual leukocyte subpopulations has not been undertaken.
METHOD OF STUDY: Expression of the natural cytotoxicity receptors NKp30, NKp44 and NKp46 by decidual leukocytes were studied by reverse transcriptase polymerase chain reaction. Expression of the killer cell Ig‐like receptors CD158a and CD158b on decidual T cells were studied by flow cytometry.
RESULTS: First trimester decidual leukocytes expressed mRNA for the NKp30 and NKp46 receptors but expression of NKp44, a marker of activated NK cells, was not detected. A mean of 11.8 and 15.8% of decidual T cells expressed CD158a or 158b, respectively, while only around 1% of peripheral blood T cells were CD158a+ or CD158b+.
CONCLUSIONS: Like peripheral blood NK cells, decidual NK cells express the natural cytotoxicity receptors NKp30 and NKp46 but the significance of this will not become apparent until ligands for these molecules have been identified. Only a minority of decidual T cells express CD158, indicating that this is not a mechanism for inhibition of cytotoxicity mediated by all decidual T cells. PROBLEMDetailed analysis of the expression of natural killer (NK) cell activatory and inhibitory receptors by human decidual leukocyte subpopulations has not been undertaken.METHOD OF STUDYExpression of the natural cytotoxicity receptors NKp30, NKp44 and NKp46 by decidual leukocytes were studied by reverse transcriptase polymerase chain reaction. Expression of the killer cell Ig-like receptors CD158a and CD158b on decidual T cells were studied by flow cytometry.RESULTSFirst trimester decidual leukocytes expressed mRNA for the NKp30 and NKp46 receptors but expression of NKp44, a marker of activated NK cells, was not detected. A mean of 11.8 and 15.8% of decidual T cells expressed CD158a or 158b, respectively, while only around 1% of peripheral blood T cells were CD158a+ or CD158b+.CONCLUSIONSLike peripheral blood NK cells, decidual NK cells express the natural cytotoxicity receptors NKp30 and NKp46 but the significance of this will not become apparent until ligands for these molecules have been identified. Only a minority of decidual T cells express CD158, indicating that this is not a mechanism for inhibition of cytotoxicity mediated by all decidual T cells. PROBLEM: Detailed analysis of the expression of natural killer (NK) cell activatory and inhibitory receptors by human decidual leukocyte subpopulations has not been undertaken. METHOD OF STUDY: Expression of the natural cytotoxicity receptors NKp30, NKp44 and NKp46 by decidual leukocytes were studied by reverse transcriptase polymerase chain reaction. Expression of the killer cell Ig‐like receptors CD158a and CD158b on decidual T cells were studied by flow cytometry. RESULTS: First trimester decidual leukocytes expressed mRNA for the NKp30 and NKp46 receptors but expression of NKp44, a marker of activated NK cells, was not detected. A mean of 11.8 and 15.8% of decidual T cells expressed CD158a or 158b, respectively, while only around 1% of peripheral blood T cells were CD158a + or CD158b + . CONCLUSIONS: Like peripheral blood NK cells, decidual NK cells express the natural cytotoxicity receptors NKp30 and NKp46 but the significance of this will not become apparent until ligands for these molecules have been identified. Only a minority of decidual T cells express CD158, indicating that this is not a mechanism for inhibition of cytotoxicity mediated by all decidual T cells. Detailed analysis of the expression of natural killer (NK) cell activatory and inhibitory receptors by human decidual leukocyte subpopulations has not been undertaken. Expression of the natural cytotoxicity receptors NKp30, NKp44 and NKp46 by decidual leukocytes were studied by reverse transcriptase polymerase chain reaction. Expression of the killer cell Ig-like receptors CD158a and CD158b on decidual T cells were studied by flow cytometry. First trimester decidual leukocytes expressed mRNA for the NKp30 and NKp46 receptors but expression of NKp44, a marker of activated NK cells, was not detected. A mean of 11.8 and 15.8% of decidual T cells expressed CD158a or 158b, respectively, while only around 1% of peripheral blood T cells were CD158a+ or CD158b+. Like peripheral blood NK cells, decidual NK cells express the natural cytotoxicity receptors NKp30 and NKp46 but the significance of this will not become apparent until ligands for these molecules have been identified. Only a minority of decidual T cells express CD158, indicating that this is not a mechanism for inhibition of cytotoxicity mediated by all decidual T cells. |
| Author | NEWTON, DARREN J. LEWIS, BARRY J. JOHNSON, PETER M. CHRISTMAS, STEPHEN E. CROKER, SIMON LENNON, GREIG P. |
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| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13785387$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12389599$$D View this record in MEDLINE/PubMed |
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| Keywords | Pregnancy Natural killer cell Human Uterus Leukocyte Female genital system T-Lymphocyte Cytotoxicity Female Decidua Gene expression Biological receptor |
| Language | English |
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| Notes | ArticleID:AJI1O115 istex:6DFF7E0EC49BEFC9300FB5D32B22CF8F475AE252 Presented at the VIII International Congress of Reproductive Immunology, Opatija, Croatia, July 2-6, 2001. ark:/67375/WNG-KZ9JNH0Q-D ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| SubjectTerms | Biological and medical sciences CD158 Cytotoxicity, Immunologic Decidua - cytology Decidua - immunology endometrial granular leukocytes Female Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression Humans Killer Cells, Natural - immunology killer inhibitory receptors Mother. Fetoplacental unit. Mammary gland. Milk natural cytotoxicity receptors Natural Cytotoxicity Triggering Receptor 3 Pregnancy Pregnancy Trimester, First - immunology Pregnancy. Parturition. Lactation Receptors, Immunologic - biosynthesis Reverse Transcriptase Polymerase Chain Reaction T-lymphocytes T-Lymphocytes - immunology T-Lymphocytes - metabolism Vertebrates: reproduction |
| Title | Natural Killer Cell Receptor Expression by Human First Trimester Decidual Granular Leukocytes and T-Lymphocytes |
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