Influence of the T cell receptor alpha-chain on T cell reactivity and tolerance to Mls-1 in T cell receptor beta-chain transgenic mice

Previous analyses of a TCR V beta 8.1 transgenic mouse revealed multiple mechanisms of tolerance to the retroviral superantigen, Mls-1. Whereas some T cells were clonally deleted in the thymus, others became anergic in the periphery, or remained unaffected by the expression of Mls-1. In addition, a...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 151; no. 2; pp. 556 - 565
Main Authors:	Blackman, MA, Smith, HP, Le, P, Woodland, DL
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Am Assoc Immnol 15-07-1993 American Association of Immunologists
Subjects:	AIDS/HIV Animals Animals, Newborn - immunology Biological and medical sciences CD4-CD8 Ratio Fundamental and applied biological sciences. Psychology Fundamental immunology Immune Tolerance Immunobiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice Mice, Inbred CBA Mice, Transgenic Minor Lymphocyte Stimulatory Antigens - analysis Minor Lymphocyte Stimulatory Antigens - immunology Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - physiology T-Lymphocytes - immunology Immune response Cell function T cell receptor Rodentia Beta-Peptide chain Transgenic animal Minor histocompatibility system Vertebrata Mammalia Mouse Immune tolerance T-Lymphocyte Alpha-Peptide chain α/β T cell receptor
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!