Refined Genetic Mapping of the Darier Locus to a <1-cM Region of Chromosome 12q24.1, and Construction of a Complete, High-Resolution P1 Artificial Chromosome/Bacterial Artificial Chromosome Contig of the Critical Region

Darier disease (DD) (MIM 124200) is an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and by abnormal keratinization. We present linkage analysis showing, in four families, key recombination events that refine the location of the DD locus on chromosome 12q...

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Bibliographic Details
Published in:	American journal of human genetics Vol. 62; no. 4; pp. 890 - 903
Main Authors:	Monk, Sarah, Sakuntabhai, Anavaj, Carter, Simon A., Bryce, Steven D., Cox, Roger, Harrington, Louise, Levy, Elaine, Ruiz-Perez, Victor L., Katsantoni, Eleni, Kodvawala, Ahmer, Munro, Colin S., Burge, Susan, Larrègue, Marc, Nagy, Gyula, Rees, Jonathan L., Lathrop, Mark, Monaco, Anthony P., Strachan, Tom, Hovnanian, Alain
Format:	Journal Article
Language:	English
Published:	Chicago, IL Elsevier Inc 01-04-1998 University of Chicago Press
Subjects:	Bacterial artificial chromosome contig Biological and medical sciences Chromosome 12 Chromosome Mapping Chromosomes, Artificial, Yeast Chromosomes, Bacterial Chromosomes, Human, Pair 12 Darier disease Darier Disease - genetics Dermatology DNA, Recombinant Female Haplotypes Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue Humans Male Mapping, refined Medical sciences P1 artificial chromosome contig Pedigree YAC contig P1 artificial chromosome contig Bacterial artificial chromosome contig Chromosome 12 YAC contig Darier disease Mapping, refined Genetic mapping Human Skin disease High resolution Linkage Family study Hyperkeratosis Chromosome C12 Artificial chromosome Genetic determinism Genetic disease Gene Cytogenetics Technique Molecular biology Locus
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