Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection

• Published in: Cancers Vol. 16; no. 7; p. 1427
• Main Authors: Ursu, Cristina-Paula, Ciocan, Andra, Ursu, Ștefan, Ciocan, Răzvan Alexandru, Gherman, Claudia Diana, Cordoș, Ariana-Anamaria, Vălean, Dan, Pop, Rodica Sorina, Furcea, Luminița Elena, Procopeț, Bogdan, Ștefănescu, Horia, Moiș, Emil Ioan, Al Hajjar, Nadim, Graur, Florin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-04-2024
• Subjects: Ascites; Care and treatment; Catheters; Cirrhosis; Clinical significance; Glycoproteins; Hepatitis B; Hepatocellular carcinoma; Hepatoma; Hypertension; Liver; Liver cancer; Liver cirrhosis; Liver diseases; Liver transplants; Lymphocytes; Malignancy; Medical prognosis; Mortality; Multivariate analysis; Patient outcomes; Patients; Serum levels; Statistical analysis; Surgery; Survival; Tumors; Venous pressure; α-Fetoprotein; Romania; liver stiffness; tumor burden score; hepatic venous pressure gradient; liver resection; hepatocellular carcinoma
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers16071427

Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measurement (TE-LSM), and the association between TBS (tumor burden score), alpha-fetoprotein levels, and the Child-Pugh classification (TAC score) can serve as valuable prognostic indicators for these patients. Therefore, the main objective of our research was to analyze the prognostic value of the HVPG, TE-LSM, TBS, and TAC scores. An observational and survival study was conducted on 144 subjects. Our findings indicated that HVPG greater than 10 mmHg, AFP surpassing 400 ng/mL, an advanced C-P class, and low TAC score are independent predictors of overall survival. During the multivariate analysis, AFP serum levels and C-P class proved statistically significant. The present study revealed significant differences in overall survival between the two groups divided upon HVPG values and settled by the cutoff of 10 mmHg (
= 0.02). Moreover, by dividing the cohort into three groups based on the TAC score (very low, low, and moderate), statistically significant differences in overall survival were observed across the groups (
= 0.004).