Effect of a topical formulation containing Calophyllum brasiliense Camb. extract on cutaneous wound healing in rats

• Published in: Natural product research Vol. 29; no. 10; pp. 953 - 957
• Main Authors: Lordani, T.V.A., Brenzan, M.A., Cortez, L.E.R., Lordani, C.R.F., Honda, P.A., Lonardoni, M.V.C., Cortez, D.A.G.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 19-05-2015
• Subjects: Administration, Cutaneous; Animals; Calophyllum - chemistry; Calophyllum brasiliense; Chromatography, High Pressure Liquid; crude extract; Emulsions; Fibroblasts - drug effects; Male; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Leaves - chemistry; rat; Rats; Rats, Wistar; Skin - drug effects; topical treatment; wound healing; Wound Healing - drug effects; Calophyllum brasiliense; wound healing; rat; crude extract; topical treatment
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2014.956742

This study evaluated the wound healing effects of topical application of an emulsion containing the HPLC-standardised extract from Calophyllum brasiliense Cambess (Clusiaceae) leaves in rats. The macroscopic analysis demonstrated that the wounds treated with the C. brasiliense emulsion healed earlier than the wounds treated with emulsion base and Dersani®. The percentage of wound healing in the group treated with the C. brasiliense emulsion was significantly higher than in the other groups at 7 and 14 days. On day 14, the animals treated with the C. brasiliense emulsion exhibited a 90.67% reduction of the wound areas. The histological evaluation revealed that on day 21, the group treated with the C. brasiliense emulsion exhibited a significant increase in fibroblasts compared with the other groups. Thus, the C. brasiliense emulsion had healing properties in the topical treatment of wounds and accelerated the healing process.