GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples

Although not completely understood, the role of the Hedgehog-GLI (HH-GLI) signaling pathway in melanoma and epithelial skin tumors has been reported before. In this study, we confirmed in various melanoma cell line models that keratin 16 (KRT16) and S100 Calcium-Binding Protein A7 (S100A7) are trans...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 11; p. 6084
Main Authors:	Kurtović, Matea, Piteša, Nikolina, Čonkaš, Josipa, Hajpek, Helena, Vučić, Majda, Musani, Vesna, Ozretić, Petar, Sabol, Maja
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-06-2024 MDPI
Subjects:	Aged Analysis biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell growth Cell Line, Tumor Cytokines Development and progression Disease DNA binding proteins epidermis Epidermis - metabolism Epidermis - pathology Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Genetic transcription HH-GLI Humans Keratin Keratin-16 - genetics Keratin-16 - metabolism keratins Male Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - pathology Metastasis Middle Aged Protein binding Proteins Psoriasis S100 Calcium Binding Protein A7 - genetics S100 Calcium Binding Protein A7 - metabolism S100A7 Skin Skin cancer Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumor staging Up-Regulation Zinc Finger Protein GLI1 - genetics Zinc Finger Protein GLI1 - metabolism Germany California Croatia melanoma keratins biomarkers HH-GLI S100A7 epidermis
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