Eleven human platelet systems studied in the Vietnamese and Ma'ohis Polynesian populations

• Published in: Tissue antigens Vol. 63; no. 1; pp. 34 - 40
• Main Authors: Halle, L., Bach K, H., Martageix, C., Bianchi, F., Lê T Kim, T., Morel-Kopp, M.C., Soulier, J., Tetaria, C., Kaplan, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01-01-2004
• Subjects: Adult; anthropology; Antigens, Human Platelet - genetics; Ethnic Groups - genetics; Female; Gene Frequency; genetic diversity; Genotype; human platelets antigens (HPA); Humans; immunization; Kinh Vietnamese; Male; Oceania; polymerase chain reaction single-restriction fragment length polymorphism; polymerase chain reaction single-sequence-specific primers; Polymorphism, Restriction Fragment Length; Polynesia; Polynesian Ma'ohis; Population - genetics; Vietnam; Vietnam; Polynesia
• ISSN: 0001-2815; 1399-0039
• DOI: 10.1111/j.1399-0039.2004.00149.x

:  The frequencies of human platelet antigens (HPA) are variable among different ethnic groups. Platelet phenotyping and genotyping in different populations are important to the clinical implications of antiplatelet alloimmunization. No report on HPA prevalence has been published concerning the Vietnamese Kinh and Ma'ohis Polynesian populations. Recent anthropological and genetic marker studies suggest that these two groups have a common origin in East Asia, so we have conducted a combined study concerning the frequency of HPA‐1 to HPA‐11w systems (excluding HPA‐8w) and Gov in these two populations. The results demonstrate a similar pattern of prevalence between Ma'ohis and most of the Asian populations. However, it should be noted that the frequency of HPA‐2 is closer to northern Caucasian frequencies than to Asian frequencies. The population of Kinh shows an HPA distribution that is closer to the Chinese population than to the northeastern Thais except for HPA‐3, closer to the Indonesian population. Given HPA‐3 gene frequency distribution fetomaternal incompatibility could occur more frequently with the risk of alloantibody production.