Antiplatelet activity of chrysin via inhibiting platelet αIIbβ3-mediated signaling pathway

Scope Propolis is thought to help prevent thrombotic and related cardiovascular diseases in humans. Chrysin, a bioflavonoids compound found in high levels in propolis and in honey, has been reported to possess antiplatelet activity. However, the mechanism by which it inhibits platelet function is un...

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Bibliographic Details
Published in:	Molecular nutrition & food research Vol. 60; no. 9; pp. 1984 - 1993
Main Authors:	Liu, Gang, Xie, Wen, He, Ao-Di, Da, Xing-Wen, Liang, Ming-Lu, Yao, Guang-qiang, Xiang, Ji-Zhou, Gao, Cun-ji, Ming, Zhang-Yin
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 01-09-2016
Subjects:	Adult Chrysin Collagen - pharmacology Dose-Response Relationship, Drug Female Flavonoids - pharmacology Glycoprotein VI pathway Humans Integrin αIIbβ3 Male Mitogen-Activated Protein Kinase 1 - metabolism Phosphatidylinositol 3-Kinases - metabolism Phospholipase C gamma - metabolism Phosphorylation - drug effects Platelet Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Syk Kinase - metabolism Platelet Chrysin Integrin αIIbβ3 Glycoprotein VI pathway
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