The synthetic oleanane triterpenoid CDDO‐2P‐Im binds GRP78/BiP to induce unfolded protein response‐mediated apoptosis in myeloma

Synthetic oleanane triterpenoids (SOTs) are small molecules with broad anticancer properties. A recently developed SOT, 1‐[2‐cyano‐3,12‐dioxooleana‐1,9(11)‐dien‐28‐oyl]‐4(‐pyridin‐2‐yl)‐1H‐imidazole (CDDO‐2P‐Im or ‘2P‐Im’), exhibits enhanced activity and improved pharmacokinetics over CDDO‐Im, a pre...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular oncology Vol. 17; no. 12; pp. 2526 - 2545
Main Authors:	Luo, George, Aldridge, Kristin, Chen, Toby, Aslot, Vivek, Kim, Byung‐Gyu, Han, Eun Hyang, Singh, Neelima, Li, Sai, Xiao, Tsan Sam, Sporn, Michael B., Letterio, John J.
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-12-2023 Wiley
Subjects:	Animal models Animals Antibodies Apoptosis Cancer CDDO‐2P‐Im Cell cycle Cell Line, Tumor Cytokines DNA damage Endoplasmic reticulum Endoplasmic Reticulum Chaperone BiP Enzymes GRP78 Humans Imidazole Imidazoles - pharmacology Kinases Mice Multiple myeloma Multiple Myeloma - drug therapy myeloma Pharmacokinetics Phosphatase Plasmacytoma Proteasome inhibitors Proteasomes Protein folding Protein kinase R Proteins Reverse transcription Transcription factors triterpenoid Triterpenoids Unfolded Protein Response UPR United States > US Germany CDDO-2P-Im triterpenoid GRP78 apoptosis myeloma UPR
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!