Identification of a duplicated V3 domain in NS5A associated with cirrhosis and hepatocellular carcinoma in HCV-1b patients

• Published in: Journal of clinical virology Vol. 69; pp. 203 - 209
• Main Authors: Le Guillou-Guillemette, H, Ducancelle, A, Bertrais, S, Lemaire, C, Pivert, A, Veillon, P, Bouthry, E, Alain, S, Thibault, V, Abravanel, F, Rosenberg, A.R, Henquell, C, André-Garnier, E, Petsaris, O, Vallet, S, Bour, J.B, Baazia, Y, Trimoulet, P, André, P, Gaudy-Graffin, C, Bettinger, D, Larrat, S, Signori-Schmuck, A, Saoudin, H, Pozzetto, B, Lagathu, G, Minjolle-Cha, S, Stoll-Keller, F, Pawlotsky, J.M, Izopet, J, Payan, C, Lunel-Fabiani, F
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-08-2015; Elsevier
• Subjects: Adult; Aged; Allergy and Immunology; Carcinoma, Hepatocellular - virology; Cirrhosis; Cross-Sectional Studies; Female; France; Gene Duplication; Hepacivirus - genetics; Hepatitis C virus; Hepatitis C, Chronic - virology; Hepatocellular carcinoma; Human health and pathology; Humans; Infectious Disease; Life Sciences; Liver Cirrhosis - virology; Liver Neoplasms - virology; Male; Middle Aged; Mutagenesis, Insertional; NS5A; Prevalence; Protein Structure, Tertiary; RNA, Viral - analysis; Sequence Analysis, RNA; V3 domain; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - genetics; France; Cirrhosis; Hepatocellular carcinoma; V3 domain; Hepatitis C virus; NS5A; hepatitis C virus; cirrhosis; hepatocellular carcinoma
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2015.06.096

Highlights • Identification of a duplicated V3-NS5A domain in HCV1b strains infected French patients. • The prevalence of this strain in our multicenter cohort was 3.05%. • The duplication was present in the entire quasispecies at any time of the infection. • The duplication prevalence increased with the liver disease severity.